sequential experimentation in clinical trials design and analysis 298 springer series in statistics

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Sequential Experimentation In Clinical Trials

Author : Jay Bartroff
ISBN : 9781461461142
Genre : Medical
File Size : 54. 16 MB
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Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information. Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.

Optimal Design For Nonlinear Response Models

Author : Valerii V. Fedorov
ISBN : 9781439821510
Genre : Mathematics
File Size : 80. 81 MB
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Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping. The common goals of experimental design—such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints—are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.

Methods And Applications Of Statistics In The Life And Health Sciences

Author : N. Balakrishnan
ISBN : 9780470405093
Genre : Mathematics
File Size : 69. 80 MB
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"Data collection holds an essential part in dictating the future of health sciences and public health, as the compilation of statistics allows researchers and medical practitioners to monitor trends in health status, identify health problems, and evaluate the impact of health policies and programs. Methods and Applications of Statistics in the Life and Health Sciences serves as a single, one-of-a-kind resource on the wide range of statistical methods, techniques, and applications that are applied in modern life and health sciences in research. Specially designed to present encyclopedic content in an accessible and self-contained format, this book outlines thorough coverage of the underlying theory and standard applications to research in related disciplines such as biology, epidemiology, clinical trials, and public health. Uniquely combining established literature with cutting-edge research, this book contains classical works and more than twenty-five new articles and completely revised contributions from the acclaimed Encyclopedia of Statistical Sciences, Second Edition. The result is a compilation of more than eighty articles that explores classic methodology and new topics."--Publisher's description.

The Theory Of The Design Of Experiments

Author : D.R. Cox
ISBN : 9781420035834
Genre : Mathematics
File Size : 66. 38 MB
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Why study the theory of experiment design? Although it can be useful to know about special designs for specific purposes, experience suggests that a particular design can rarely be used directly. It needs adaptation to accommodate the circumstances of the experiment. Successful designs depend upon adapting general theoretical principles to the special constraints of individual applications. Written for a general audience of researchers across the range of experimental disciplines, The Theory of the Design of Experiments presents the major topics associated with experiment design, focusing on the key concepts and the statistical structure of those concepts. The authors keep the level of mathematics elementary, for the most part, and downplay methods of data analysis. Their emphasis is firmly on design, but appendices offer self-contained reviews of algebra and some standard methods of analysis. From their development in association with agricultural field trials, through their adaptation to the physical sciences, industry, and medicine, the statistical aspects of the design of experiments have become well refined. In statistics courses of study, however, the design of experiments very often receives much less emphasis than methods of analysis. The Theory of the Design of Experiments fills this potential gap in the education of practicing statisticians, statistics students, and researchers in all fields.

Statistics In The 21st Century

Author : Martin A. Tanner
ISBN : 9781420035391
Genre : Mathematics
File Size : 72. 86 MB
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Exactly what is the state of the art in statistics as we move forward into the 21st century? What promises, what trends does its future hold? Through the reflections of 70 of the world's leading statistical methodologists, researchers, theorists, and practitioners, Statistics in the 21st Century answers those questions. Originally published in the Journal of the American Statistical Association, this collection of vignettes examines our statistical past, comments on our present, and speculates on our future. Although the coverage is broad and the topics diverse, it reveals the essential intellectual unity of the field as we see the same themes recurring in different contexts. We see how the development of statistics has been driven by the unprecedented and still growing range of applications, by the explosion in computer technology, and by the new types of data that continue to emerge and advance the discipline. Organized around major areas of application and leading up to vignettes on theory and methods, Statistics in the 21st Century forms a landmark record of the progress and perceived future of the discipline. No student, researcher, or practitioner of statistics should miss this extraordinary opportunity to view the past, present, and future world of statistics through the eyes of its foremost thinkers.

Clinical Evaluation Of Psychotropic Drugs

Author : Robert F. Prien
ISBN : UOM:39015032611132
Genre : Medical
File Size : 90. 26 MB
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Assessment & measurement of clinical change/pharmacologic considerations/clinical trial implementation/etc.

Proceedings Of The Ist World Congress Of The Bernoulli Society Mathematical Statistics Theory And Applications

Author : Bernoulli Society for Mathematical Statistics and Probability. World Congress
ISBN : 9067641057
Genre : Mathematical statistics
File Size : 22. 98 MB
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Statistica Sinica

Author :
ISBN : UOM:39015072605580
Genre : Mathematical statistics
File Size : 31. 38 MB
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Biometrics

Author :
ISBN : UCAL:B5031665
Genre :
File Size : 70. 22 MB
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Current Index To Statistics Applications Methods And Theory

Author :
ISBN : UOM:39015050441222
Genre : Mathematical statistics
File Size : 66. 89 MB
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