receptors model systems and specific receptors 11 methods in neurosciences

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The Receptors

Author : P. Michael Conn
ISBN : 9781483273266
Genre : Science
File Size : 87. 4 MB
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The Receptors, Volume IV deals with receptors for intracellular hormones, estrogen, and sex steroids as well as for dopamine, cholecystokinin, and corticotropin. The role of surface recognition receptors in disease is also discussed, along with receptors for plant auxin action and auxin transport. Comprised of 11 chapters, this volume begins with a detailed account of the ?-adrenergic receptor-coupled adenylate cyclase and the reconstitution of the functional interactions of its various purified components. The discussion then turns to the mechanism of action of steroid and thyroid hormones and how abnormalities in their receptors lead to disease; nuclear location of estrogen receptors; and the biochemistry of the fungal sex steroid receptors as well as the use of Achlya as a model system for the study of the mechanism of action of steroid hormones in general. Subsequent chapters focus on dopamine receptors; cholecystokinin receptor; corticotropin receptors; and the search for receptors that mediate sweetness. The book concludes with an analysis of endocrine receptors on lymphocytes and the integration of endocrine and immune systems, with emphasis on large granular lymphocytes. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

Lipid Metabolism In Signaling Systems

Author : John N. Fain
ISBN : 9781483288321
Genre : Science
File Size : 79. 56 MB
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Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain

Computers And Computations In The Neurosciences

Author : P. Michael Conn
ISBN : 9781483259512
Genre : Technology & Engineering
File Size : 39. 73 MB
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Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

Receptor Molecular Biology

Author :
ISBN : 0080536441
Genre : Medical
File Size : 66. 45 MB
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The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Cloning Expression systems Signal transduction Structure-function techniques Antireceptor antibodies Regulation 3-D receptor modeling and computational probing

Neurobiology Of The Parental Brain

Author : Robert Bridges
ISBN : 0080559573
Genre : Psychology
File Size : 82. 88 MB
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This book presents cutting edge research on the basic neurobiology of parental behavior as it relates to behavioral disorders, including postpartum depression, anxiety, and inadequate parental bonding to infants. Internationally recognized basic and clinical researchers present new research findings in humans and animals that elucidate the roles of the brain, physiological state, genes and environment in maternal and paternal care. By bridging the gap between basic and clinical research, new understandings of how the biology of the brain and the reproductive state of the parent impact their mental health and the successful rearing of young emerge. * Presents the neural network of motherhood based on fundamental and functional MRI studies of parental care - from rodents to humans * Discusses the role of gene-environment interactions in parenting * Offers parenting strategies and priorities in raising young * Discusses maternal defense - the neurobiology of maternal protection * Examines the significance and underlying causes of postpartum depression * Discusses parenting and anxiety – neurobiological basis for reductions during the postpartum period * Also includes the neurobiology of fatherhood – a fresh evolutionary and biological perspective on paternal behavior * Presents information on maternal neuroplasticity - how reproductive history changes the maternal brain * Translates research – internationally renowned researchers' insights into common factors that regulate mammalian parenting

The British National Bibliography

Author : Arthur James Wells
ISBN : UOM:39015079755404
Genre : English literature
File Size : 25. 2 MB
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Issues In Science And Technology

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ISBN : UCBK:C054364113
Genre : Electronic journals
File Size : 21. 64 MB
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Buyer S Guide

Author : William White
ISBN : UVA:X002274166
Genre : Library science
File Size : 67. 39 MB
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Cellular And Molecular Methods In Neuroscience Research

Author : Adalberto Merighi
ISBN : 9780387224602
Genre : Medical
File Size : 68. 52 MB
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There are numerous books on cellular and molecular protocols for general use in cell biology but very few are exclusively devoted to neurobiology. This book fills this gap and explains in a clear and consistent manner, some of the more commonly used protocols in neuroscience research. Each chapter is written by either the person who invented the procedure or an expert in the field. The format is uniform: "Overview," "Background," "Protocols," and "results and discussion." Each protocol begins with the principle of the technique, studies in cell culture, materials and reagents, and, lastly, step-by-step outline of the procedure itself. This highly practical book is also well illustrated (with 17 four color plates) to make the concepts and procedures easy to understand and perform.

The Library Journal

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ISBN : UOM:39015082964381
Genre : Libraries
File Size : 35. 27 MB
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Includes, beginning Sept. 15, 1954 (and on the 15th of each month, Sept.-May) a special section: School library journal, ISSN 0000-0035, (called Junior libraries, 1954-May 1961). Also issued separately.

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