practical synthetic organic chemistry reactions principles and techniques

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Practical Synthetic Organic Chemistry

Author : Stéphane Caron
ISBN : 9781118093566
Genre : Science
File Size : 79. 59 MB
Format : PDF
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A hands-on guide to assist in the planning and execution ofsynthetic reactions in the laboratory Despite the maturity of organic chemistry, it can still be verychallenging to identify optimal methods for synthetictransformations that perform as well in real-world manufacturingprocesses as they do in the laboratory. This detailed andaccessible guide attempts to address this vexing issue and deliverproven methodologies practicing synthetic chemists will findvaluable for identifying reaction conditions that work reliablyover the broadest possible range of substrates. Practical Synthetic Organic Chemistry: Provides a practical guide to strategically planning andexecuting chemical syntheses for the bench chemist in industry Discusses information that is not common knowledge beyond theboundaries of process chemistry groups, such as the syntheticroutes of selected contemporary pharmaceutical drugs and practicalsolvents, as well as green chemistry concepts Highlights key reactions, including substitutions, additions,eliminations, rearrangements, oxidations, and reductions Addresses basic principles, mechanisms, advantages anddisadvantages of the methodology, and techniques for achievinglaboratory success Incorporating such an extraordinary wealth of information onorganic chemistry and its related fields into one complete volumedistinguishes Practical Synthetic Organic Chemistry as anincomparable desktop reference for professionals—and aninvaluable study aid for students.

Practical Synthetic Organic Chemistry

Author : Stéphane Caron
ISBN : 9780470037331
Genre : Science
File Size : 69. 55 MB
Format : PDF, ePub
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"This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory"--Provided by publisher.

Practical Process Research And Development

Author : Neal G. Anderson
ISBN : 9780123865373
Genre : Science
File Size : 58. 66 MB
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Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Early Drug Development

Author : Fabrizio Giordanetto
ISBN : 9783527801770
Genre : Science
File Size : 57. 68 MB
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This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Organic Photochemistry

Author : Jacques Kagan
ISBN : 9780080984414
Genre : Science
File Size : 39. 30 MB
Format : PDF
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Organic Photochemistry outlines the principles, techniques and well-known reactions occurring in organic molecules and also illustrates more complex photochemical transformations occurring in organic chemistry. Many photochemical transformations convert simple molecules into extremely complex products with an ease not approached by the standard synthetic chemistry practiced in the laboratory. In the earlier chapters, the author outlines the principles, techniques and some of the well-known reactions occurring in organic molecules and later illustrates more complex photochemical transformations occuring in organic chemistry. Experimental techniques are included to encourage novices. Topics are emphasized where structural transformations can be formulated chemically. Practical applications are collected together. The book starts at a comfortably simple level with enough examples to provide an introduction to the diversity of photochemical reactions. * Includes experimental techniques to encourage novices. * Emphasizes topics where structural transformations can be formulated chemically * Collects and presents practical applications * Written in a simple style including enough examples to serve as an introduction to the diversity of photochemical reactions

Supplement For Basic Principles Of Organic Chemistry

Author : John D. Roberts
ISBN : UCAL:B4165418
Genre : Chemistry, Organic
File Size : 69. 88 MB
Format : PDF, Docs
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Experimental Organic Chemistry

Author : Philippa B. Cranwell
ISBN : 9781119952381
Genre : Science
File Size : 74. 8 MB
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Previous edition by Laurence M. Harwood, Christopher J. Moody, and Jonathan M. Percy.

Molecular Diversity And Combinatorial Chemistry

Author : Michael C. Pirrung
ISBN : 0080444938
Genre : Medical
File Size : 75. 77 MB
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Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

High Throughput Synthesis

Author : Irving Sucholeiki
ISBN : 1420056514
Genre : Science
File Size : 76. 26 MB
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An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.

Aziridines And Epoxides In Organic Synthesis

Author : Andrei K. Yudin
ISBN : 9783527607488
Genre : Science
File Size : 69. 10 MB
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Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.

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