Release on 2018-10-29 | by Joris J. Roelofs,Liffert Vogt
Pathophysiology and Clinical Aspects
Author: Joris J. Roelofs,Liffert Vogt
This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.
This volume will focus on and emphasise the clinical relevance of diabetic nephropathy, a relatively common problem of diabetes. It affects about one in three patients with Type 1 diabetes, and left untreated can lead to a progressive decline in renal function, accompanied by retinopathy and arterial hypertension, which, in turn, leads to cardiovascular disease - a common cause of death in these patients. Diabetic Nephropathy will also provide the reader with a solid grounding in current basic and clinical research.
Pubpsher: Karger Medical and Scientific Publishers
Type-2 diabetic nephropathy is one of the major long-term microvascular complications occurring in nearly 40% of diabetic patients in Japan. The purpose of this book is to review recent work on the genetic background, pathogenesis and treatment of this disorder and to provide the most up-to-date findings on these subjects in Japan.The pathogenesis of diabetic nephropathy includes both metabolic and / or hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient, for its initiation and progression: The toxicity of persistent hyperglycemia results from glucose overutilization and multiple secondary effects. Moreover, diabetic nephropathy is generally considered to alter the chemical composition of the glomerular basement membrane and mesangium. At present, it is supposed that the increases in extracellular matrix accumulation due to TGF-beta activation might be related to the glomerular sclerosis in diabetic nephropathy. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy.Presenting clinical findings and issues related to laboratory analysis, this book will be of interest for nephrologists, diabetologists, pathologists, biochemists, general physicians and residents.
Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy
Release on 2019-11-08 | by Luigi Gnudi,David A. Long
Methods and Protocols
Author: Luigi Gnudi,David A. Long
This book provides a toolkit of novel research approaches for investigators to study diabetic nephropathy, including critical experimental models from the fly to the fish, cells in culture, and in vivo mammalian approaches. The collection also explores powerful techniques to image the kidney, such as traditional histological techniques as well as electron, confocal, and two-photon microscopy, pathophysiology of the diabetic kidney, and gene editing and regenerative medicine. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Diabetic Nephropathy: Methods and Protocols seeks to foster new research directions and inspire ideas to enhance our understanding of diabetic nephropathy and to develop treatments for this condition.
Patients with diabetes should be screened annually for microalbuminuria and eGFR (estimated glomerular filtration rate), and have their blood pressure checked. All abnormal results must be treated effectively.
Diabetes and the Kidney provides endocrinologists andnephrologists of all levels with expert clinical diagnosis andmanagement guidance for this extremely common diabeticcomplication. Practical and accessible, chapters contain textfeatures such as case histories, potential pitfall boxes, keypoints, management algorithms, and useful weblinks to fullyengage the reader and provide expert guidance to help cliniciansbest manage their patients. In addition, allrelevant international society guidelines and recommendationsare fully included. After an initial analysis of the epidemiology andpathogenesis of kidney complications in diabetes, it quickly moveson to the following core sections: • Special Situations, Risk factors and Complications- examining diabetic nephropathy in relation to each other diabeticcomplication, ie cardiovascular disease • Prevention and Therapy - focusing on the most up todate information regarding prevention, diagnosis, treatment, andmanagement of kidney disease in diabetes. Expertly edited, and with contributions from an experiencedinternational team, Diabetes and Kidney Disease will be theperfect tool to consult when managing diabetic patients withassociated kidney problems.
Awareness of neuropathy as a chronic complication of diabetes is constantly increasing. Diabetes centers adopt methods to diagnose neuropathy without neurological training. This trend calls for instructions on how to use and interpret diagnostic methods. This book includes recent research and covers clinical, technical, and public health aspects of neuropathy, bringing together the top experts in the field.
Release on 2001-12-12 | by Jean Marie Ekoé,J.-M. Ekoé,P. Zimmet,George Alberti,Rhys Williams
An International Perspective
Author: Jean Marie Ekoé,J.-M. Ekoé,P. Zimmet,George Alberti,Rhys Williams
Pubpsher: John Wiley & Sons
This seminal work brings together, for the first time, information on international trends and data for diabetes mellitus. Diabetes is on the increase throughout both the developed and developing world. Currently there are approximately 150 million people with diabetes worldwide, mainly Type 2 diabetes, and it is possible that as many as half of the cases have not been diagnosed. These numbers are likely to increase over the next 25 years. This text takes an international look at the epidemiology of diabetes, focusing primarily on geographical aspects of the disease. Topics covered include: Etiological factors and time trends Definitions and evidence for prevention Caucasian populations Non-Caucasian populations Associated risk factors and complications Implications The Epidemiology of Diabetes Mellitus: An International Perspective is essential reading for every diabetologist, clinical endocrinologist, epidemiologist and all the members of the diabetes specialist team.