Clinical Genomics: Practical Applications for Adult Patient Care

Clinical Genomics: Practical Applications for Adult Patient Care

The first book on the clinical application of genetics in primary care medicine, Clinical Genomics focuses on the everyday application of genetic assessment and its diagnostic, therapeutic, and preventive implications in clinical practice. Unlike traditional textbooks on medical genetics and dysmorphology, this is a clinical reference that covers many of the common diseases seen in everyday medical practice. Features: endorsed by the American College of Physicians; addresses the genetic basis of common chronic diseases, not just the classic diseases of dysmorphology.

Implementing and Evaluating Genomic Screening Programs in Health Care Systems

Proceedings of a Workshop

Implementing and Evaluating Genomic Screening Programs in Health Care Systems

Genomic applications are being integrated into a broad range of clinical and research activities at health care systems across the United States. This trend can be attributed to a variety of factors, including the declining cost of genome sequencing and the potential for improving health outcomes and cutting the costs of care. The goals of these genomics-based programs may be to identify individuals with clinically actionable variants as a way of preventing disease, providing diagnoses for patients with rare diseases, and advancing research on genetic contributions to health and disease. Of particular interest are genomics- based screening programs, which will, in this publication, be clinical screening programs that examine genes or variants in unselected populations in order to identify individuals who are at an increased risk for a particular health concern (e.g., diseases, adverse drug outcomes) and who might benefit from clinical interventions. On November 1, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop to explore the challenges and opportunities associated with integrating genomics-based screening programs into health care systems. This workshop was developed as a way to explore the challenges and opportunities associated with integrating genomics-based programs in health care systems in the areas of evidence collection, sustainability, data sharing, infrastructure, and equity of access. This publication summarizes the presentations and discussions from the workshop.

Case Studies in Geriatric Primary Care & Multimorbidity Management - E-Book

Case Studies in Geriatric Primary Care & Multimorbidity Management - E-Book

Gain expertise in primary care of older adults with a case-based approach to geriatric primary care and multimorbidity management. Written by two leading academic and clinical experts in geriatric primary care, Case Studies in Geriatric Primary Care and Multimorbidity Management, 1st Edition uses detailed Exemplar Case Studies and Practice Case Studies to teach you how to think like an expert geriatric clinician. Because most older adults have more than one condition when seeking care, both Exemplar and Practice Case Studies place a strong emphasis on "multimorbidity" management, (the management of patients with a host of complex, interacting conditions). To provide extensive practice in learning how to think like an expert, case studies reflect the reality that care does not necessarily begin or end in the primary care setting. Cases therefore move fluidly from primary care to acute care to inpatient rehabilitation to assisted living to long-term care. Building on foundational introductory chapters, cases also call on you to develop interprofessional collaboration skills and reflect the diversity of today's older adults, in terms of age (young-old to old-old), gender, culture, ethnicity, sexuality, socioeconomic status, and more! As you work through both basic-level and advanced Practice Case Studies, you can make extensive notes in the printed book and then go online to submit answers for grading and receive expert feedback for self-reflection. NEW! Introductory unit on the core principles of caring for older adults gives you a strong foundation in the principles of geriatric primary care and multimorbidity management. NEW! and UNIQUE! Exceptionally detailed, unfolding Exemplar Case Studies demonstrate how an expert advanced practitioner "thinks clinically" to provide care to older adults with multiple conditions. NEW and UNIQUE! Exceptionally detailed, unfolding Practice Case Studies emphasize patient diversity and multimorbidity management across healthcare settings to help you develop advanced clinical reasoning skills for geriatric primary care. NEW and UNIQUE! Strong emphasis on multimorbidity management focuses on caring for older adults with multiple chronic conditions. NEW! Emphasis on the continuum of care across settings reflects the reality that care does not necessarily begin or end in the primary care setting but can move from primary care to acute care to inpatient rehabilitation to assisted living to long-term care, and so forth. NEW! Online answer submission for grading and expert feedback for self-reflection. NEW! Emphasis on patient diversity reflects the makeup of today's older adult, population in terms of age (young-old to old-old), gender, culture, ethnicity, sexuality, socioeconomic status, and more. NEW! Emphasis on interprofessional collaboration use Exemplar Case Studies and Practice Case Studies to allow you to demonstrate your interprofessional collaboration skills.

Statin-Associated Muscle Symptoms

Statin-Associated Muscle Symptoms

This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.

Geriatric Notes

Geriatric Notes

Geriatric Notes is an essential quick reference for the advanced practice provider (APP) who provides care to elders in the outpatient setting, such as nursing homes, family practice, or home health. With a practical, accessible, and concise approach, it offers an easy to understand overview of the most common diagnoses, topics, and symptoms encountered in the aging population. Designed to offer access to the basics, this guide provides tables and bullet points for easy reference. Sections include health promotion, neurology and psychiatry, cardiovascular, pulmonary, gastroenterology, genitourinary, rheumatology, dermatology, endocrinology, labs, Beers list, and common presentations.

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Handbook of Clinical Adult Genetics and Genomics

A Practice-Based Approach

Handbook of Clinical Adult Genetics and Genomics

Handbook of Clinical Adult Genetics and Genomics: A Practice-Based Approach provides a thorough overview of genetic disorders that are commonly encountered in adult populations and supports the full translation of adult genetic and genomic modalities into clinical practice. Expert chapter authors supplement foundational knowledge with case-based strategies for the evaluation and management of genetic disorders in each organ system and specialty area. Topics discussed include employing genetic testing technologies, reporting test results, genetic counseling for adult patients, medical genetics referrals, issues of complex inheritance, gene therapy, and diagnostic and treatment criteria for developmental, cardiovascular, gastrointestinal, neuropsychiatric, pulmonary issues, and much more. Employs clinical case studies to demonstrate how to evaluate, diagnosis and treat adult patients with genetic disorders Offers a practical framework for establishing an adult genetics clinic, addressing infrastructure, billing, counseling, and challenges unique to adult clinical genetics Features chapter contributions from authors at leading adult genetics institutions in the US and abroad

Advanced Physiology and Pathophysiology

Essentials for Clinical Practice

Advanced Physiology and Pathophysiology

Specifically designed for future healthcare providers who will diagnose, manage, and prescribe. This advanced physiology and pathophysiology text is designed to address the specific learning needs of future nurse practitioners, physician assistants, and other advanced healthcare providers caring for patients across the lifespan. Focusing on practical applications of physiology, it facilitates in-depth understanding of important pathophysiological concepts as they relate to major disorders commonly seen in clinical practice and includes comprehensive pediatric and geriatric considerations. This knowledge is crucial to providing the foundation required to be an informed and confident clinical decision maker. The author team includes experienced clinicians and educators: nurses and nurse practitioners, physician assistants, doctors of pharmacy, physicians, and basic scientists. This collaboration has produced a text that carefully details and richly illustrates the cellular structure and function of each organ system and mechanisms of associated major clinical disorders. Uniquely interweaving aspects of organ function during healthy states with disease-associated changes, the text emphasizes and extends the basic science foundation to practical clinical applications. The text promotes a deep understanding of cellular function in health and disease that provides the bedrock knowledge required to master pharmacology for prescriptive practice. Equally important, the solid foundation of applied pathophysiological mechanisms offered in this text prepares the student clinician to care for patients with a broad variety of disorders. This resource not only provides a deep dive into pathophysiology, but it also examines WHY patients often present with particular symptoms, the rationale for ordering specific diagnostic tests and interpretation of results, and common management strategies that proceed from the underlying pathophysiology. Key Features: Designed explicitly to build a foundation for pharmacology and clinical courses that lead to successful clinical practice and prescribing Includes comprehensive lifespan considerations with key insights from specialists in pediatric and geriatric pathophysiology Provides a complete chapter on the basic principles of genetics and genomics with coverage of genetic variations, assessment, and genomics woven throughout the book Integrates thought questions and case studies to promote discussion and synthesis of information Offers a unique Bridge to Clinical Practice in each chapter to translate science to patient care Includes more than 500 images to illustrate complex scientific concepts Summarizes the contents succinctly with handy key points at the end of each chapter Provides access to the fully searchable ebook, including student ancillaries on Springer Publishing ConnectTM Offers robust instructor resources, including instructor manual, test bank, PowerPoint lectures for each chapter, image bank, and more!

Seminars in General Adult Psychiatry

Seminars in General Adult Psychiatry

This second edition of Seminars in General Adult Psychiatry provides a highly readable and comprehensive account of modern adult psychiatry. More than nine years have passed since the publication of the first edition, and significant advances have been made in almost every area of psychiatry. This single volume assimilates these modern developments and their effects on clinical practice. To achieve this has meant incorporating more than 4000 references, with many of the more important studies being described in some detail so as to provide the reader with some of the original data on which modern evidence-based medicine depends. Key features of the first edition that have been retained are the detailed clinical descriptions of psychiatric disorders, and historical sections to give the reader access to the classic studies of psychiatry as well as the current evidence. Additional topics covered here for the first time include liaison psychiatry, psychosexual medicine, clinical epidemiology, and international and cultural psychiatry. Clinical management is given due prominence, with extensive accounts of modern drug management, cognitive therapy, the main psychosocial approaches, and current guidelines such as those published by NICE. An essential text for trainees studying for their MRCPsych, this book is also a one-stop reference work for established practitioners. Comprehensive coverage of the whole of adult psychiatry. Detailed clinical descriptions of both common and rare psychiatric disorders. Accounts of the history, epidemiology, diagnosis and clinical management of all the broad categories of disorder. An evidence-based approach. New chapters on liaison psychiatry, clinical epidemiology, psychosexual medicine, and international and cultural psychiatry. Easy to read, with more than 260 tables and boxes summarising key information. New compact, single-volume format.

Role of Intravenous Levetiracetam in Acute Seizure Management

Role of Intravenous Levetiracetam in Acute Seizure Management

Intractable epilepsy still remains the main issue despite new advances in medical and surgical treatment of epilepsy. Acute seizure management in a timely manner is crucial to prevent irreversible brain damage. Benzodiazepines still remain the first initial treatment to abort the seizure activity. The approval phenytoin, fosphenytoin, intravenous valproate, and rectal diazepam provided additional options. The approval of intravenous levetiracetam gave another option to physicians if and when the above treatment fails to control the seizure activity. In this Ebook, we have included chapters from renowned researchers in the field of neurology and epilepsy who have covered the various aspects of these agents in detail including the properties, mechanism of action, pharmacology, neurobehavioral effects, and the roles of these agents in special populations including traumatic brain injury and brain tumor related epilepsy. These data further show that intravenous levetiracetam can be used in acute seizure management and in special circumstances.