biocatalysis for the pharmaceutical industry

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Biocatalysis For The Pharmaceutical Industry

Author : Junhua (Alex) Tao
ISBN : 9780470823156
Genre : Science
File Size : 76. 98 MB
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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Biocatalysis In The Pharmaceutical And Biotechnology Industries

Author : Ramesh N. Patel
ISBN : 9781420019377
Genre : Science
File Size : 53. 20 MB
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Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.

Biocatalysis And Pharmaceuticals A Smart Tool For Sustainable Development

Author : Andres R Alcantara
ISBN : 9783039217083
Genre : Science
File Size : 58. 39 MB
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Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.

Practical Methods For Biocatalysis And Biotransformations 2

Author : John Whittall
ISBN : 9781118307861
Genre : Technology & Engineering
File Size : 82. 70 MB
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Biocatalysts are increasingly used by chemists engaged in finechemical synthesis within both industry and academia. Today, thereexists a huge choice of high-tech enzymes and whole cellbiocatalysts, which add enormously to the repertoire of syntheticpossibilities. Practical Methods for Biocatalysis and Biotransformations2 is a "how-to" guide that focuses on the practicalapplications of enzymes and strains of microorganisms that arereadily obtained or derived from culture collections. The sourcesof starting materials and reagents, hints, tips and safety advice(where appropriate) are given to ensure, as far as possible, thatthe procedures are reproducible. Comparisons to alternativemethodology are given and relevant references to the primaryliterature are cited. This second volume – which can be usedon its own or in combination with the first volume - concentrateson new applications and new enzyme families reported since thefirst volume. Contents include: introduction to recent developments and future needs inbiocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficientalkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation andphosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations2 is an essential collection of biocatalytic methods forchemical synthesis which will find a place on the bookshelves ofsynthetic organic chemists, pharmaceutical chemists, and processR&D chemists in industry and academia.

Green Biocatalysis

Author : Ramesh N. Patel
ISBN : 9781118822296
Genre : Science
File Size : 83. 76 MB
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This book describes the enzyme-driven syntheses of industrially important compounds and chiral intermediates for chemicals and pharmaceuticals. The chapters describe recent technological advances in enzymatic and microbial transformations and are written by internationally renowned scientists and professors. The synthesis of industrially important molecules is described from the starting substrate to the final product and includes detailed mechanisms. This book addresses the use of various types of reactions catalyzed by microbial cells or enzymes derived from microbes in the production of industrially useful compounds and a variety of drugs. The production of chiral alcohols, amines, unnatural amino acids, esters, carboxylic acids, epoxides, hydroxylated compounds and drug metabolites as well as recent advances in enzyme catalyzed acylation, dehalogenation, esterification, oxidation-reduction, transamination, deamination, C-N, C-C, C-O bond formation, Baeyer-Villegar reaction and aldol as well as acyloin condensation reactions are covered. Cutting-edge topics such as directed evolution by gene shuffling and enzyme engineering to improve biocatalysts will be presented. Enzyme immobilization and reusability studies and enzymatic protection and deprotection are addressed as well.

Applied Biocatalysis In Pharmaceuticals

Author : Vivek Kothari
ISBN : 8176221708
Genre : Enzymes
File Size : 59. 84 MB
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Bioacatalysis Has Increasingly Become The Technology Of Choice To Introduce Chirality In Fine-Chemical Processes. Biocatalysis Sculpts Chemical Precursors Into The Precise Molecular Shapes That Are The Heart Of Many Pharmaceuticals. In Reviewing How Biocatalysis Can Be Applied To Improve Chiral Synthesis For Pharmaceutical It Becomes Clear That There Will Be Many Opportunities Using A Simple Enzyme System But That Many Of The More Useful Applications Will Require The Whole Cell Because Of The Requirement For Cofactors. In The Ever More Global Commercial Arena, Biocatalysts Becomes Ever More Central To The Competitiveness Of Individual Products, Companies, Industries, And Countries. The Use Of Biocatalysis Often Leads To Less Complex, Syntheses, Lower Production Costs, And More Sustainable Production Processes. Written For Practitioners And Students Of Chemistry, Biology And Bioengineering, This Book Provides A Comprehensive Review Of The Applications Of Biocatalysis In The Pharmaceutical Industry. Contents Chaptre 1: Introduction; Chapter 2: Synthesis Of Chiral Intermediates; Chapter 3: Synthesis Of Amino Alcohols; Chapter 4: Enzymatic Synthesis Of Amplicillin; Chapter 5: Synthesis Of Chiral Amines With W-Transaminase; Chapter 6: Synthesis Of Chiral Long Chain Diamines And Tetramines; Chapter 7: Applications For Oxidoreductases; Chapter 8: Non-Aqueous Biocatalysis; Chapter 9: Eukaryotes For Industrial Biocatalysis; Chapter 10: Biopolymers For Biocatalysis; Chapter 11: Use Of Enantiopure Naphthalene Dihydrodiols; Chapter 12: Multidrug-Resistant Mycobacterium Tuberculosis; Chapter 13: Flavin Biochemistry.

Modern Biocatalysis

Author : Wolf-Dieter Fessner
ISBN : 9783527623846
Genre : Science
File Size : 50. 55 MB
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This reference covers the wide and rapidly growing field of biocatalysis. It combines complementary expertise from such areas as microbiology, enzymology, molecular biology structural biology and organic chemistry, thus highlighting the interdisciplinary nature of the subject. With its special focus on progress and new developments towards environmentally beneficial reactions with high levels of selectivity for the production of key compound classes, this book will enlighten both chemists and biologists as to the advances and opportunities existing in enzyme catalysis.

Biocatalysis For Synthesis Of Pharmaceuticals

Author :
ISBN : OCLC:1052031035
Genre :
File Size : 84. 35 MB
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Graphical abstract: Abstract: Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates and drugs has become important and state of the art in the pharmaceutical industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes (biocatalysts) for the transformation of synthetic chemicals with high chemo-, regio- and enatioselectivities providing products in high yields and purity. In this article, biocatalytic processes are described for the synthesis of key chiral intermediates for development pharmaceuticals.


Author : Gonzalo de Gonzalo
ISBN : 9781782626190
Genre : Biocatalysis
File Size : 57. 36 MB
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Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Biocatalysis For Green Chemistry And Chemical Process Development

Author : Junhua (Alex) Tao
ISBN : 1118028295
Genre : Technology & Engineering
File Size : 30. 50 MB
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This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

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