biocatalysis for the pharmaceutical industry

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Biocatalysis For The Pharmaceutical Industry

Author : Junhua (Alex) Tao
ISBN : 9780470823156
Genre : Science
File Size : 22. 44 MB
Format : PDF
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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Biocatalysis In The Pharmaceutical And Biotechnology Industries

Author : Ramesh N. Patel
ISBN : 9781420019377
Genre : Science
File Size : 30. 14 MB
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Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.

Biocatalysts For The Pharmaceutical Industry Created By Structure Guided Directed Evolution Of Stereoselective Enzymes

Author :
ISBN : OCLC:1051975984
Genre :
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Graphical abstract: Abstract: Enzymes have been used for a long time as catalysts in the asymmetric synthesis of chiral intermediates needed in the production of therapeutic drugs. However, this alternative to man-made catalysts has suffered traditionally from distinct limitations, namely the often observed wrong or insufficient enantio- and/or regioselectivity, low activity, narrow substrate range, and insufficient thermostability. With the advent of directed evolution, these problems can be generally solved. The challenge is to develop and apply the most efficient mutagenesis methods which lead to highest-quality mutant libraries requiring minimal screening. Structure-guided saturation mutagenesis and its iterative form have emerged as the method of choice for evolving stereo- and regioselective mutant enzymes needed in the asymmetric synthesis of chiral intermediates. The number of (industrial) applications in the preparation of chiral pharmaceuticals is rapidly increasing. This review features and analyzes typical case studies.

Practical Methods For Biocatalysis And Biotransformations 2

Author : John Whittall
ISBN : 9781118307861
Genre : Technology & Engineering
File Size : 61. 7 MB
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Biocatalysts are increasingly used by chemists engaged in finechemical synthesis within both industry and academia. Today, thereexists a huge choice of high-tech enzymes and whole cellbiocatalysts, which add enormously to the repertoire of syntheticpossibilities. Practical Methods for Biocatalysis and Biotransformations2 is a "how-to" guide that focuses on the practicalapplications of enzymes and strains of microorganisms that arereadily obtained or derived from culture collections. The sourcesof starting materials and reagents, hints, tips and safety advice(where appropriate) are given to ensure, as far as possible, thatthe procedures are reproducible. Comparisons to alternativemethodology are given and relevant references to the primaryliterature are cited. This second volume – which can be usedon its own or in combination with the first volume - concentrateson new applications and new enzyme families reported since thefirst volume. Contents include: introduction to recent developments and future needs inbiocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficientalkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation andphosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations2 is an essential collection of biocatalytic methods forchemical synthesis which will find a place on the bookshelves ofsynthetic organic chemists, pharmaceutical chemists, and processR&D chemists in industry and academia.

Green Biocatalysis

Author : Ramesh N. Patel
ISBN : 9781118822357
Genre : Technology & Engineering
File Size : 80. 1 MB
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Green Biocatalysis presents an exciting green technology that uses mild and safe processes with high regioselectivity and enantioselectivity. Bioprocesses are carried out under ambient temperature and atmospheric pressure in aqueous conditions that do not require any protection and deprotection steps to shorten the synthetic process, offering waste prevention and using renewable resources. Drawing on the knowledge of over 70 internationally renowned experts in the field of biotechnology, Green Biocatalysis discusses a variety of case studies with emphases on process R&D and scale-up of enzymatic processes to catalyze different types of reactions. Random and directed evolution under process conditions to generate novel highly stable and active enzymes is described at length. This book features: A comprehensive review of green bioprocesses and application of enzymes in preparation of key compounds for pharmaceutical, fine chemical, agrochemical, cosmetic, flavor, and fragrance industries using diverse enzymatic reactions Discussion of the development of efficient and stable novel biocatalysts under process conditions by random and directed evolution and their applications for the development of environmentally friendly, efficient, economical, and sustainable green processes to get desired products in high yields and enantiopurity The most recent technological advances in enzymatic and microbial transformations and cuttingedge topics such as directed evolution by gene shuffling and enzyme engineering to improve biocatalysts With over 3000 references and 800 figures, tables, equations, and drawings, Green Biocatalysis is an excellent resource for biochemists, organic chemists, medicinal chemists, chemical engineers, microbiologists, pharmaceutical chemists, and undergraduate and graduate students in the aforementioned disciplines.

Green Biocatalysis

Author : Ramesh N. Patel
ISBN : 9781118822296
Genre : Science
File Size : 82. 41 MB
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This book describes the enzyme-driven syntheses of industrially important compounds and chiral intermediates for chemicals and pharmaceuticals. The chapters describe recent technological advances in enzymatic and microbial transformations and are written by internationally renowned scientists and professors. The synthesis of industrially important molecules is described from the starting substrate to the final product and includes detailed mechanisms. This book addresses the use of various types of reactions catalyzed by microbial cells or enzymes derived from microbes in the production of industrially useful compounds and a variety of drugs. The production of chiral alcohols, amines, unnatural amino acids, esters, carboxylic acids, epoxides, hydroxylated compounds and drug metabolites as well as recent advances in enzyme catalyzed acylation, dehalogenation, esterification, oxidation-reduction, transamination, deamination, C-N, C-C, C-O bond formation, Baeyer-Villegar reaction and aldol as well as acyloin condensation reactions are covered. Cutting-edge topics such as directed evolution by gene shuffling and enzyme engineering to improve biocatalysts will be presented. Enzyme immobilization and reusability studies and enzymatic protection and deprotection are addressed as well.

Modern Biocatalysis

Author : Wolf-Dieter Fessner
ISBN : 9783527623846
Genre : Science
File Size : 35. 83 MB
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This reference covers the wide and rapidly growing field of biocatalysis. It combines complementary expertise from such areas as microbiology, enzymology, molecular biology structural biology and organic chemistry, thus highlighting the interdisciplinary nature of the subject. With its special focus on progress and new developments towards environmentally beneficial reactions with high levels of selectivity for the production of key compound classes, this book will enlighten both chemists and biologists as to the advances and opportunities existing in enzyme catalysis.


Author : Gonzalo de Gonzalo
ISBN : 9781782626190
Genre : Biocatalysis
File Size : 32. 2 MB
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Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Handbook Of Industrial Biocatalysis

Author : Ching T. Hou
ISBN : 9781420027969
Genre : Science
File Size : 49. 80 MB
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Until now, no comprehensive handbook on industrial biocatalysis has been available. Soliciting chapters on virtually every aspect of biocatalysis from international experts most actively researching the field, the Handbook of Industrial Biocatalysis fills this need. The handbook is divided into three sections based on types of substrates. The first section describes the newest biotechnology and bioprocesses for producing industrial products from hydrophobic substrates such as oils and fats. The discussion of biocatalysis covers single and multiple catalytic reactions involved in the creation of products as well as molecular manipulation of enzymes and product recovery. The products include healthy food, nutritional supplements, nutraceuticals, specialty chemicals, surfactants, biopolymers, and antimicrobial agents. The second section covers the production of value-added products from carbohydrate substrates. The scope of this section includes ethanol production, oligosaccharides and glycosides, utilization of hemicelluloses, and carbohydrate-active enzymes. The third section is dedicated to other potential industrial applications such as bioelectrocatalysis for synthesizing chemicals, fuels, and new drugs. The authors explore novel nutrition delivery systems, green chemistry, and the industrial applications of extremophiles. The organizer of several annual worldwide symposia on biocatalysis, editor Ching T. Hou has compiled a cornerstone reference for scientists in academic, industrial, and government research institutes, as well as for graduate-level students involved in biosciences, chemical engineering, biotechnology, microbiology, oil and colloid chemistry, and food chemistry.

Marine Enzymes For Biocatalysis

Author : Antonio Trincone
ISBN : 9781908818355
Genre : Science
File Size : 35. 16 MB
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Marine bioprospecting is a highly topical subject - in both applied and basic research - but, as yet, the marine ecosystem is a relatively unexplored source of natural bioactive substances with potential therapeutic activity. This book addresses the use of marine enzymes in biocatalysis through a series of chapters from leading scientists within academic and industrial fields. Biocatalytic processes can take advantage of the habitat-related properties of marine enzymes, such as salt tolerance, hyperthermostability, barophilicity, cold adaptivity, and so on, whilst also taking into consideration substrate specificity and affinity. These evolved properties are linked to the metabolic functions of the enzymes and to the ecological aspects of the natural source. New properties can also be discovered at the molecular level of catalysis, particularly concerning the stereochemical characteristics of products. Marine enzymes for biocatalysis initially examines the nature and level of interest in marine biological diversity, and outlines the fundamentals of biocatalysis. It goes on to detail sources of marine enzymes, and to analyse examples from both chemical and stereochemical viewpoints of catalysis, including microbial enzymes and animal or plant sources. The book goes on to explore the future potential of marine bioprospecting in biocatalysis. Compiles studies from leading scientists in a direct and accessible format. Includes practical descriptions of results, adding further details not often covered in formal articles Takes a molecular view which fully explains the enzymatic aspects of reactions, particularly regarding biocatalytic characteristics and descriptions of bioprocesses Selects examples of chemical and stereochemical aspects of enzymatic action with respect to known terrestrial counterparts

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