voltage gated sodium channels handbook of experimental pharmacology

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Voltage Gated Sodium Channels

Author : Peter C. Ruben
ISBN : 9783642415883
Genre : Medical
File Size : 43. 82 MB
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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Voltage Gated Sodium Channels

Author : Peter Ruben
ISBN : 3642415873
Genre : Medical
File Size : 34. 40 MB
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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Voltage Gated Sodium Channels Structure Function And Channelopathies

Author : Mohamed Chahine
ISBN : 9783319902845
Genre : Medical
File Size : 90. 32 MB
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This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Na Channels From Phyla To Function

Author :
ISBN : 9780128092538
Genre : Science
File Size : 53. 27 MB
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Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels. Written by leading experts in the field of Na Channels Contains original material, both textual and illustrative, that make it a very relevant reference Presented in a very comprehensive manner Both researchers in the field and general readers will find this book relevant and up-to-date with regard to its information

Chemical And Biochemical Approaches For The Study Of Anesthetic Function

Author :
ISBN : 9780128127414
Genre : Science
File Size : 58. 74 MB
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Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data. We have selected the primary experts to write about each approach This provides one-stop shopping for all the means of addressing this complex question Anesthesia is enormously important as almost everybody receives it at some point

Allgemeine Und Spezielle Pharmakologie Und Toxikologie

Author : Klaus Aktories
ISBN : 9783437172120
Genre : Medical
File Size : 57. 91 MB
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Wer mit „Aktories" lernt, versteht Das gesamte Wissen der Pharmakologie und Toxikologie ist so verständlich und anschaulich erklärt, dass man seit Jahrzehnten auf dieses Standardwerk schwört. Mit über 1200 Seiten, rund 800 Abbildungen und 300 Tabellen ist diese 12. Auflage auf dem neuesten Stand der Wissenschaft: Arzneimittelwirkungen im Gesamtzusammenhang begreifen: Wirkmechanismen und pathophysiologische Bezüge in jedem Kapitel Zusammenhänge verstehen: Ausführliches Kapitel zur allgemeinen Pharmakologie und Toxikologie erleichtert das Verständnis der speziellen pharmakologischen Zusammenhänge Praktische Relevanz: Empfehlungen zu Therapie und Dosierungen in farbig hervorgehobenen Kästen Der „Aktories" – bewährt als erstklassiges Lehrbuch für Medizinstudenten, begehrt als Nachschlagewerk für Ärzte, Pharmakologen und Pharmazeuten.

Pharmacology And Therapeutics For Dentistry E Book

Author : John A. Yagiela
ISBN : 9780323078245
Genre : Medical
File Size : 57. 21 MB
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Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Goodman And Gilman S The Pharmacological Basis Of Therapeutics 13th Edition

Author : Laurence Brunton
ISBN : 9781259584749
Genre : Medical
File Size : 75. 69 MB
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The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.

Goodman Gilman S The Pharmacological Basis Of Therapeutics

Author : Louis Sanford Goodman
ISBN : MINN:31951D01253435P
Genre : Chemotherapy
File Size : 59. 64 MB
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For more than fifty years, scientists, clinicians, & students have relied on "Goodman & Gilman for the final word on the pharmacokinetics, mechanisms of action & therapeutic application of drugs. This edition sustains that proud tradition & infuses the latest information on molecular pharmacology as it redefines the definite database of pharmacologic therapeutics. As a course text or a daily reference in clinical practice, "G & G" offers the optimal mix of basic science & clinical coverage as it pertains to effective drug therapy.

Goodman And Gilman S The Pharmacological Basis Of Therapeutics

Author : Louis Sanford Goodman
ISBN : 0071354697
Genre : Medical
File Size : 67. 64 MB
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Goodman & Gilman is the Bible of pharmacology as it has been since the first edition written by Louis Goodman and Alfred Gilman and published in 1941. It is the definitive textbook for all medical and pharmacy students and is a must have purchase for residents in internal medicine and pharmacologists. The book is a higher level than our Katzung and should be considered as the perfect accompaniment to the new Harrison. The objective of this textbook/ reference work is to provide a comprehensive and up-to-date correlation of pharmacology with related medical sciences, a reinterpretation of the actions and uses of drug from the view point of the latest advances in medicine and pace emphasis on the application of pharmacodynamics to therapeutics. Throughout its history, Goodman & Gilman has become more than a textbook. It is a working template for effective and rational prescribing of drugs in daily practice. The careful balance of basic science and clinical application has guided students and practitioners to a better understanding of how and why drugs work. The information is presented in a style that reads with maximum clarity and purpose. Transformed and expanded in the last ed

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