viral pathogenesis and immunity

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Viral Pathogenesis And Immunity

Author : Neal Nathanson
ISBN : 0080471056
Genre : Medical
File Size : 31. 93 MB
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Based on the highly successful reference work Viral Pathogenesis published in 1997, this concise, economical version can be used both as an introductory text or for self-education by medical students and biologists alike. This latest edition provides a completely revised overview of the subject with new chapters on innate immunity, emerging viral diseases, and antiviral therapy in a format that is easy to understand without continually referring to additional information. Used by the author in his graduate classes at the University of Pennsylvania, it sets forth the essential principles and discusses the details of how the immune system responds to viral invasion including the treatment and prevention of infection. Illustrated by pertinent examples it is one of the only books devoted exclusively to this topic. * Offers almost a 20% expansion over the first edition * Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic * Neal Nathanson is one of the primary authorities in the field and has authored chapters on viral pathogenesis in two of the most well known virology and microbiology titles Field's Virology and Topley and Wilson's Microbiology * Now in four color throughout!

Viral Pathogenesis And Immunity 2nd Ed 9780123694645

Author : Neal Nathanson
ISBN : OCLC:1027882811
Genre :
File Size : 56. 81 MB
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Viral Pathogenesis

Author : Michael G. Katze
ISBN : 9780128011744
Genre : Science
File Size : 42. 27 MB
Format : PDF, Kindle
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Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Studies Of Immunity In A Mouse Model For Viral Pathogenesis

Author : Greta Lynn Budweg
ISBN : OCLC:19576162
Genre : Immunoglobulins
File Size : 82. 71 MB
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The Flaviviruses Pathogenesis And Immunity

Author :
ISBN : 9780080493824
Genre : Science
File Size : 64. 19 MB
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Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family

Viral Pathogenesis In Diagrams

Author : Hans-Wolfgang Ackermann
ISBN : 1420039113
Genre : Science
File Size : 32. 75 MB
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Viral Pathogenesis in Diagrams is the first book of its kind to illustrate viral pathogenesis on a comparative basis. The text covers the pathogenesis of viral diseases, including vertebrates, invertebrates, plants, and protists. The diagrams summarize and integrate large numbers of observations, from electron microscopy to clinical data, into a single picture or a few related drawings. Organized alphabetically by virus family or groups, this book covers the complete domain of virology. Transcending photographs and experimental data, the diagrams are ideally suited to illustrate the pathogenesis of viral diseases, from infection to host defenses and cell death. Included are two chapters describing general pathogenesis in vertebrate virus infections and illustrating the spread of viruses through the body, as well as cytopathology and host defenses. One chapter illustrates the pathogenic behavior of 19 vertebrate virus families, especially herpesviruses and retroviruses. The 268 diagrams in Viral Pathogenesis in Diagrams were selected from over 800 diagrams of English and French virological literature, including one derived from a famous drawing by Leonardo da Vinci. This up-to-date reference will promote understanding and future research.

Measles Viral Pathogenesis And Immunity In The Rhesus Macaque

Author : Yong-de Zhu
ISBN : UCAL:X58050
Genre :
File Size : 81. 77 MB
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Dengue Viral Pathogenesis And Immune Response In Humanized Rag2 C Rag Hu Mice

Author : Jes G. Kuruvilla
ISBN : OCLC:971322457
Genre : Dengue viruses
File Size : 56. 23 MB
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Concepts In Viral Pathogenesis Ii

Author : Abner Louis Notkins
ISBN : 9781461249580
Genre : Science
File Size : 73. 38 MB
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Respiratory Syncytial Virus Pathogenesis And Immune Response In The Cotton Rat Model

Author : Michelle G. Green
ISBN : OCLC:1006648779
Genre : Respiratory syncytial virus
File Size : 61. 18 MB
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Respiratory syncytial virus (RSV) is a highly contagious and universally prevalent virus that presents as a respiratory infection, which can range from mild to fatal in severity. An infant’s first RSV infection is typically the most severe, but the elderly are also at risk for severe infection. Although life-threatening complications in healthy adults are less common, the burden of illness due to RSV in this population remains substantial. Clinical trials for RSV vaccine candidates began in the 1960’s, but to date, there remains no vaccine or therapeutic available. A prophylactic has been developed for RSV, although its use is limited to high-risk pre-term infants during the RSV season. This prophylactic was developed using small animal models of RSV infection. For the work presented herein, RSV pathogenesis and immune response is investigated using the cotton rat. The cotton rat is a less common, but more permissive and predictive model of RSV infection. This document is separated into four chapters. The first chapter is a review of the literature, which provides an overview of RSV, highlights what is known, and indicates areas where there are opportunities to clarify our understanding of the virus, as well as a brief discussion of the strengths and weaknesses of animal models of RSV infection. Chapter two addresses one of the uncertainties in the RSV field, the cellular receptor for the virus. Earlier studies had demonstrated heparan sulfate to be a receptor for RSV, but these studies were performed on immortalized cell lines, which express different proteins on their surface than airway epithelial cells, the target cell for RSV infection. Based on recent work using primary human airway epithelium cells, CX3CR1 was identified as a potential RSV receptor. Adding to that work, chapter two summarizes data that support CX3CR1 as a receptor in vivo using the cotton rat model. Chapter three examines eosinophils in the cotton rat and during RSV infection. This work was prompted both by conflicting results in the literature proposing an antiviral or pathological role for eosinophils during RSV infection, as well as uncertainty with regard to the morphology and function of eosinophils in the cotton rat. Prior reports of the cellular composition of the cotton rat lung did not examine eosinophils specifically. This chapter first characterizes cotton rat eosinophils, then examines the pulmonary eosinophil response to RSV infection. The number of eosinophils in the lung did not increase in response to normal RSV infection, which indicated that eosinophils are unlikely to contribute to either the clearance or pathogenesis of RSV. The last chapter, chapter four, is a partial chapter detailing work to further characterize and enhance the usefulness of the cotton rat as a model for RSV infection. Taken together, this work has contributed to the field of RSV research by confirming a cellular receptor for RSV in vivo, demonstrating that eosinophils are not normally recruited to the lungs during RSV infection, and furthering the utility of the cotton rat as a model of RSV infection.

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