unbiased stereology a concise guide

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Unbiased Stereology

Author : Peter R. Mouton
ISBN : 9781421402284
Genre : Medical
File Size : 52. 24 MB
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Those new to bioscience research as well as experienced practitioners will find that Mouton’s explanations are the perfect companion for stereology courses and workshops.

Neurostereology

Author : P. R. Mouton
ISBN : 9781118444184
Genre : Medical
File Size : 72. 75 MB
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Stereological methods provide researchers with unparalleled quantitative data from tissue samples and allow for well-evidenced research advances in a broad range of scientific fields. Presenting a concise introduction to the methodology and application of stereological research in neuroscience, Neurostereology provides a fuller understanding of the use of these methods in research and a means for replicating successful scientific approaches. Providing sound footing for future research, Neurostereology is a useful tool for basic and clinical researchers and advanced students looking to integrate these methods into their research.

Unbiased Stereology

Author : Vyvyan Howard
ISBN : 9781135331689
Genre : Science
File Size : 72. 89 MB
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Unbiased Stereology, Second Edition is a practical guide to making unbiased 3-D measurements via the microscope. Only those stereological techniques which have been tried and tested by real application are included. Although this technology is essentially mathematical and statistical, the authors do not immerse the reader in complex analysis, but rather provide simple heuristic explanations and references to the original proof, and illustrate the theory by analogies drawn from everyday experience. To give practical experience in application of the techniques, exercises are provided at the end of each chapter, complete with detailed worked answers.

Principles And Practices Of Unbiased Stereology

Author : Peter R. Mouton
ISBN : UOM:39015055600699
Genre : Medical
File Size : 67. 33 MB
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Beginning in the 1960s, scientists across a wide range of disciplines cooperated in developing unbiased -- or assumption free -- stereology, based on stochastic geometry and probability theory, as a way to estimate the parameters of irregularly shaped objects without introducing bias. In recent years these new estimation techniques, which were originally quite painstaking and time consuming, have made a great deal of headway in disciplines such as neuroscience, thanks in part to the development of computer software for their application. Prestigious journals and grant-giving organizations now require the use of unbiased stereology in the projects that they support, and this trend is expected to continue. Principles and Practices of Unbiased Stereology will fill a need in the biomedical community as a clear, user-friendly introduction to this area for the increasing number of scientists who need to learn these techniques for their research. The work moves logically from a discussion of the historical background of stereology to full explanations of terms, concepts,and tools, with the latter part of the manuscript devoted to typical stereology designs. An associated web site will feature color illustrations and video clips demonstrating stereological techniques. -- Patrick R. Hof, Mount Sinai School of Medicine

Handbook Of Imaging In Biological Mechanics

Author : Corey P. Neu
ISBN : 9781466588141
Genre : Medical
File Size : 27. 54 MB
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Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens at the nanoscale. The Handbook of Imaging in Biological Mechanics presents the spectrum of imaging techniques used for noninvasive visualization of the morphology and mechanics of the large and small—from organs to individual macromolecules. The handbook presents optimal imaging technologies to study deformation, stress, and constitutive behavior of tissues, cells, and proteins. It also describes a suite of technologies available for probing the mechanics of surfaces, membranes, and single molecules. With chapters authored by highly recognized experts in their area, the handbook covers the entire spectrum of biomechanical and mechanobiologic imaging technologies available today.

Image Analysis Of Food Microstructure

Author : John C. Russ
ISBN : 9781420038996
Genre : Technology & Engineering
File Size : 69. 23 MB
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Image Analysis of Food Microstructure offers a condensed guide to the most common procedures and techniques by which quantitative microstructural information about food can be obtained from images. The images are selected from a broad range of food items, including macroscopic images of meat and finished products such as pizza, and the microstructures of cheeses, dough and baked goods, ice cream, fruits and vegetables, emulsions, foams, and gels. The book informs food scientists about the image processing and measurement tools used to characterize a variety of microstructures in foods, using high-quality image techniques to illustrate chemical composition, thermo-mechanical processing, and genetic and structural properties. These different types of images used to measure various aspects of structure include: macroscopic light photography, confocal light microscopy, electron microscopy, atomic force microscope images, magnetic resonance, and computed tomography. Then the text explains how to interpret images to produce data, plot the results in different graphs, and identify trends. Examples using these image analysis techniques show typical results that researchers can expect and recreate. Image Analysis of Food Microstructure summarizes the basic procedures that can be useful in various aspects of food research, from nutraceuticals to cooking and food processing. It presents the processing of images and mathematical principles needed for image analyses in a step-by-step approach to extract key information from the images obtained.

Addictive Substances And Neurological Disease

Author : Ronald Ross Watson
ISBN : 9780128092965
Genre : Medical
File Size : 25. 97 MB
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Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances. Integrates current research on the actions of addictive substances in neurological disease Includes functional foods, such as caffeine beverages, that have habituating effects on the brain Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances

Handbook Of Clinical Gender Medicine

Author : K. Schenck-Gustafsson
ISBN : 9783805599306
Genre : Psychology
File Size : 47. 80 MB
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Gender medicine is an important new field in health and disease. It is derived from top-quality research and encompasses the biological and social determinants that underlie the susceptibility to disease and its consequences. In the future, consideration of the role of gender will undoubtedly become an integral feature of all research and clinical care. Defining the role of gender in medicine requires a broad perspective on biology and diverse skills in biomedical and social sciences. When these scientific disciplines come together, a revolution in medical care is in the making. Covering twelve different areas of medicine, the practical and useful Handbook of Clinical Gender Medicine provides up-to-date information on the role of gender in the clinical presentation, diagnosis, and management of a wide range of common diseases.

A Practical Guide To The Histology Of The Mouse

Author : Cheryl L. C. Scudamore
ISBN : 9781119941200
Genre : Medical
File Size : 43. 73 MB
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A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

Population Genetics

Author : John H. Gillespie
ISBN : 1421401703
Genre : Science
File Size : 82. 65 MB
Format : PDF, ePub
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This book is indispensable for students working in a laboratory setting or studying free-ranging populations.

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