translation and its regulation in cancer biology and medicine

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Translation And Its Regulation In Cancer Biology And Medicine

Author : Armen Parsyan
ISBN : 9789401790789
Genre : Medical
File Size : 61. 62 MB
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This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Translational Control In Biology And Medicine

Author : Michael Mathews
ISBN : 9780879697679
Genre : Medical
File Size : 81. 26 MB
Format : PDF
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Updated and broadened 3rd edition. Since the last edition was published, the structures of the bacterial and eukaryotic ribosomes have been published, adding substantially to our knowledge of the basic mechanisms of translation. Understanding of how translation is regulated, by both protein and RNA regulators, has also advanced considerable. In addition, the current manifesttion of this volume has a significant focus on the role of translational control in human development and disease.

The Long And Short Non Coding Rnas In Cancer Biology

Author : Erwei Song
ISBN : 9789811014987
Genre : Medical
File Size : 52. 79 MB
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The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Advances In Cancer Research

Author : George F. Vande Woude
ISBN : 0080488226
Genre : Medical
File Size : 55. 90 MB
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Advances in Cancer Research

Genomic Medicine

Author : Great Britain. Parliament. House of Lords. Science and Technology Committee
ISBN : 0108444503
Genre : Genetic screening
File Size : 74. 19 MB
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Volume 1 Report also available (ISBN 9780108444517). Genomic medicine has developed from the sequencing of the human genome

Cell Death Signaling In Cancer Biology And Treatment

Author : Daniel Johnson
ISBN : 9781461458470
Genre : Science
File Size : 62. 3 MB
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A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Cancer Biology Review

Author : Walter M. Stadler, MD
ISBN : 9781617051401
Genre : Medical
File Size : 53. 1 MB
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Utilizing the teaching value of real-world case discussions, Cancer Biology Review presents the principles of cancer biology in a clear and memorable manner, allowing the clinician to relate the cases shown in the book to those seen in practice. Focusing on ten topics in cancer biology for which there have been major changes in fundamental understanding, the authors provide a concise overview of the principles of each topic, followed by presentation of clinical cases illuminating the topic and detailed discussions. Summaries and key teaching points are highlighted at the end of each chapter to facilitate quick recall and review. The chapter authors are established translational experts in the biology being discussed as well practicing master clinicians. Cancer Biology Review is a useful tool for any oncology clinician in training or preparing for boards, and for the oncology practitioner preparing for recertification or who sees the need to be more fully conversant in the current science of the field as clinically applied. Features of Cancer Biology Review include: Presents principles of cancer biology through clinical translations and therapeutic perspective Clinical cases illustrate scientific principles as the clinician will observe them in practice Emphasis on scientific basis of current and emerging therapeutics Leading translational scientists/clinicians provide current, authoritative discussions

Redox Signaling And Regulation In Biology And Medicine

Author : Claus Jacob
ISBN : 9783527627592
Genre : Science
File Size : 26. 8 MB
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This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Mtor Inhibition For Cancer Therapy Past Present And Future

Author : Monica Mita
ISBN : 9782817804927
Genre : Medical
File Size : 36. 40 MB
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This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.

Murray Nadel S Textbook Of Respiratory Medicine E Book

Author : V.Courtney Broaddus
ISBN : 9780323261937
Genre : Medical
File Size : 26. 81 MB
Format : PDF
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Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Full-color design enhances teaching points and highlights challenging concepts. Understand clinical applications and the scientific principles of respiratory medicine. Detailed explanations of each disease entity allow you to work through differential diagnoses. Key Points and Key Reading sections highlight the most useful references and resources for each chapter. An expanded sleep section now covers four chapters and includes control of breathing, consequences of sleep disruption, as well as obstructive and central apnea. New chapters in the Critical Care section cover Noninvasive Ventilation (NIV) and Extracorporeal Support of Gas Exchange (ECMO). New chapters focusing on diagnostic techniques now include Invasive Diagnostic Imaging and Image-Guided Interventions and Positron Emission Tomography, and a new chapter on Therapeutic Bronchoscopy highlights the interventional role of pulmonologists.

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