toxoplasma gondii the model apicomplexan perspectives and methods

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Toxoplasma Gondii

Author : Louis M. Weiss
ISBN : 9780123965363
Genre : Science
File Size : 90. 2 MB
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This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients. Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists

Toxoplasma

Author : Dominique Soldati
ISBN : 9781904933342
Genre : Science
File Size : 75. 20 MB
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Toxoplasma gondii, once an obscure protozoan parasite, has recently become the focus of intense research, both as a serious pathogen in its own right and as a model member of the phylum Apicomplexa. Written by internationally acclaimed researchers, this is the first book to provide a comprehensive coverage of this important parasite from both the host and pathogen perspectives. The authors of this book describe in detail the biological characteristics that make T. gondii and related apicomplexans the most common and successful group of parasites on earth. Essential reading for all researchers working with Toxoplasma and related apicomplexans, Plasmodium, Cryptosporidium, and other protozoan parasites.

Molecular Detection Of Human Parasitic Pathogens

Author : Dongyou Liu
ISBN : 9781439812433
Genre : Medical
File Size : 84. 59 MB
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Traditionally, laboratory identification of parasites has relied upon various phenotypic procedures that detect their morphological, biological, and immunological features. Because these procedures tend to be time-consuming and technically demanding, molecular methods based on nucleic acid amplification technologies have been increasingly utilized for rapid, sensitive, and specific characterization of parasites. The large number of original and modified molecular protocols that have been developed over the years creates a dilemma for those attempting to adopt the most appropriate protocol for streamlined identification and detection of human pathogenic organisms of interest. Part of a four-volume collection, Molecular Detection of Human Parasitic Pathogens provides a reliable and comprehensive resource on the molecular detection and identification of major human parasitic pathogens. This volume contains expert contributions from international scientists involved in human parasitic pathogen research and diagnosis. Following a similar format throughout, each chapter includes: A brief review on the classification, biology, epidemiology, clinical features, and diagnosis of an important pathogenic parasitic genus/group An outline of clinical sample collection and preparation procedures and a selection of representative stepwise molecular protocols A discussion on further research needs relating to improved diagnoses of major human parasitic pathogens This versatile reference on molecular detection and identification of major human parasitic pathogens is an indispensable tool for upcoming and experienced medical, veterinary, and industrial laboratory scientists engaged in parasite characterization. It is also suitable as a textbook for undergraduate and graduate students majoring in parasitology.

Quantitative Proteomics

Author : Claire E Eyers
ISBN : 9781849738088
Genre : Science
File Size : 68. 98 MB
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As a component of post-genome science, the field of proteomics has assumed great prominence in recent years. Whereas quantitative analyses focussed initially on relative quantification, a greater emphasis is now placed on absolute quantification and consideration of proteome dynamics. Coverage of the topic of quantitative proteomics requires consideration both of the analytical fundamentals of quantitative mass spectrometry and the specific demands of the problem being addressed. Quantitative Proteomics aims to outline the state of the art in mass spectrometry-based quantitative proteomics, describing recent advances and current limitations in the instrumentation used, together with the various methods employed for generating high quality data. Details on both strategies describing how stable isotope labelling can be applied and methods for performing quantitative analysis of proteins in a label-free manner are given. The utility of these strategies to understanding cellular protein dynamics are then exemplified with chapters looking at spatial proteomics, dynamics of protein function as determined by quantifying changes in protein post-translational modification and protein turnover. Finally, a key application of these techniques to biomarker discovery and validation is presented, together with the rapidly developing area of quantitative analysis of protein-based foodstuffs. This exemplary book will be essential reading for analytical and biological mass spectrometrists working in proteomics research, as well as those undertaking either fundamental or clinical-based investigations with an interest in understanding protein dynamics and/or biomarker assessment.

Toxoplasmosis Of Animals And Humans Second Edition

Author : J. P. Dubey
ISBN : 1420092375
Genre : Science
File Size : 28. 75 MB
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Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publication of the first edition of Toxoplasmosis of Animals and Humans there has been an explosion of knowledge concerning T. gondii and toxoplasmosis. Still used extensively as a cell model, its genome has recently been published making it a subject of even greater scientific interest. Keeping the organizational style that made the previous edition so popular and usable, this second edition has been completely revised and updated. New in the Second Edition: Expanded information on the cultivation, maintenance, and preservation of T. gondii Expanded information on the cell biology and molecular biology of the parasite Reviews all literature from the past 20 years for each domestic animal Summarizes information on the worldwide prevalence of toxoplasmosis in pregnant women and the devastating disease it can cause in newborn Written by one of the pioneers of the field, the book provides unique information on all known host types for this parasite. It distills the voluminous and potentially confusing scientific literature that has grown geometrically in the 20 years since the publication of the first edition into a comprehensive resource. The single author approach ensures a strong foundation in the biology and a seamless integration of topics. The new edition of this groundbreaking work is the only volume to cover toxoplasmosis of animals and humans thoroughly in one source. It supplies an entry point to further research by cutting through the morass of literature to identify the most relevant references.

Toxoplasmosis Of Animals And Humans Second Edition

Author : J. P. Dubey
ISBN : 1420092375
Genre : Science
File Size : 41. 30 MB
Format : PDF, Kindle
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Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publication of the first edition of Toxoplasmosis of Animals and Humans there has been an explosion of knowledge concerning T. gondii and toxoplasmosis. Still used extensively as a cell model, its genome has recently been published making it a subject of even greater scientific interest. Keeping the organizational style that made the previous edition so popular and usable, this second edition has been completely revised and updated. New in the Second Edition: Expanded information on the cultivation, maintenance, and preservation of T. gondii Expanded information on the cell biology and molecular biology of the parasite Reviews all literature from the past 20 years for each domestic animal Summarizes information on the worldwide prevalence of toxoplasmosis in pregnant women and the devastating disease it can cause in newborn Written by one of the pioneers of the field, the book provides unique information on all known host types for this parasite. It distills the voluminous and potentially confusing scientific literature that has grown geometrically in the 20 years since the publication of the first edition into a comprehensive resource. The single author approach ensures a strong foundation in the biology and a seamless integration of topics. The new edition of this groundbreaking work is the only volume to cover toxoplasmosis of animals and humans thoroughly in one source. It supplies an entry point to further research by cutting through the morass of literature to identify the most relevant references.

People Parasites And Plowshares

Author : Dickson D. Despommier
ISBN : 9780231535267
Genre : Medical
File Size : 40. 17 MB
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Dickson D. Despommier's vivid, visceral account of the biology, behavior, and history of parasites follows the interplay between these fascinating life forms and human society over thousands of years. Despommier focuses on long-term host-parasite associations, which have evolved to avoid or even subvert the human immune system. Some parasites do great damage to their hosts, while others have signed a kind of "peace treaty" in exchange for their long lives within them. Many parasites also practice clever survival strategies that medical scientists hope to mimic as they search for treatments for Crohn's disease, food allergies, type 1 diabetes, organ transplantation, and other medical challenges. Despommier concentrates on particularly remarkable and often highly pathogenic organisms, describing their lifecycles and the mechanisms they use to avoid elimination. He details their attack and survival plans and the nature of the illnesses they cause in general terms, enabling readers of all backgrounds to steal a glimpse into the secret work of such effective invaders. He also points to the cultural contexts in which these parasites thrive and reviews the current treatments available to defeat them. Encouraging scientists to continue to study these organisms even if their threat is largely contained, Despommier shows how closer dissection of the substances parasites produce to alter our response to them could help unravel some of our most complex medical conundrums.

Foodborne Parasites

Author : Ynes R. Ortega
ISBN : 9780387311975
Genre : Technology & Engineering
File Size : 23. 68 MB
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This book examines the two major parasite groups that are transmitted via water or foods: the single-celled protozoa, and the helminths: cestodes (tapeworms), nematodes (round worms), and trematodes (flukes). Each chapter covers the biology, mechanisms of pathogenesis, epidemiology, treatment, and inactivation of these parasites. This important new text offers a better understanding of the biology and control of parasitic infections necessary to reduce or eliminate future outbreaks in the U.S. and elsewhere.

Manual Of Clinical Microbiology

Author : James Versalovic
ISBN : 9781555814632
Genre : Medical
File Size : 80. 99 MB
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The most authoritative, comprehensive reference in the field. • Sets the standard for state-of-the-science laboratory practice. • A collaborative effort of 22 editors and more than 260 authors from around the world, all experienced researchers and practitioners in medical and diagnostic microbiology. • Includes 149 chapters of the latest research findings, infectious agents, methods, practices, and safety guidelines. • Indispensable to clinical microbiologists, laboratory technologists, and infectious disease specialists in hospitals, clinics, reference laboratories, and more

Toxoplasmosis

Author : David H. M. Joynson
ISBN : 0521019427
Genre : Medical
File Size : 89. 78 MB
Format : PDF
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This authoritative and comprehensive account looks at the reemergence of toxoplasmosis as a significant and potentially fatal infection. A team of acknowledged international experts review the latest diagnostic techniques, and the management of infection in pregnant women, neonates, the eye, transplant and other immunosuppressed patients, including AIDS patients. The contentious issue of the role of screening during pregnancy and in the newborn is covered in depth. The introductory chapters on biology, immunology, and epidemiology of the infection provide essential background to understanding the clinical disease. The full range of treatment strategies are presented in an easily accessible form.

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