the minipig in biomedical research

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The Minipig In Biomedical Research

Author : Peter A. McAnulty
ISBN : 9781439811191
Genre : Medical
File Size : 86. 22 MB
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The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

Advances In Swine In Biomedical Research

Author : Mike E. Tumbleson
ISBN : 0306454963
Genre : Medical
File Size : 50. 67 MB
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Contains papers from the October 1995 symposium, in sections on methods and techniques, and nutrition. Subjects include the Yucatan miniature pig model of ventricular septal defect, the minipig as a model for the study of aging in humans, an external thoracic duct venous shunt to allow for long-term

Sourcebook Of Models For Biomedical Research

Author : P. Michael Conn
ISBN : 9781588299338
Genre : Medical
File Size : 37. 78 MB
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The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Animal Models In Toxicology Third Edition

Author : Shayne C. Gad
ISBN : 9781466554290
Genre : Medical
File Size : 46. 69 MB
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Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

Swine In The Laboratory

Author : M. Michael Swindle
ISBN : 142000915X
Genre : Medical
File Size : 35. 81 MB
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To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. The book focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. New to the Second Edition Updated sections on anesthesia and perioperative care, including practical information for more complex models Expansion of anatomic and physiologic details Additional detail in the endoscopy section Chapters on toxicology and radiobiology Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images More tables of normal values on the most commonly used minipigs and domestic breeds Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedical research.

Swine In Biomedical Research

Author : Mike E. Tumbleson
ISBN : UOM:39015011656090
Genre : Medical
File Size : 86. 20 MB
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Molecular And Functional Models In Neuropsychiatry

Author : Jim J. Hagan
ISBN : 3642197035
Genre : Medical
File Size : 29. 83 MB
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The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

Undersea Biomedical Research

Author :
ISBN : UCSD:31822008905267
Genre : Pressure
File Size : 22. 71 MB
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The Welfare Of Laboratory Animals

Author : Eila Kaliste
ISBN : 9781402022715
Genre : Science
File Size : 81. 42 MB
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This book examines the general principles of laboratory animal maintenance and experimental use as well as factors that have to be taken into account when good research is done with animals. In addition, it provides species specific coverage, concentrating on the species most used as laboratory animals. The book gives a comprehensive description of the welfare questions considered to be important for each species under laboratory conditions.

International Symposium Swine In Biomedical Research

Author :
ISBN : UIUC:30112006086349
Genre : Medicine
File Size : 24. 1 MB
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