the dopamine receptors the receptors

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The Dopamine Receptors

Author : Kim Neve
ISBN : 9781475726350
Genre : Medical
File Size : 45. 28 MB
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Seven years after the cloning of the rat dopamine D receptor, and four 2 years after the cloning of the last mammalian dopamine receptor identified to date, this seems to be an excellent time to put together the present The Dopamine Receptors volume ofthis series, The Receptors. There has been time for considerable characterization of the novel receptor subtypes, and new, exciting lines of research from the molecular to the behavioral levels are taking shape. We asked the contributors to The Dopamine Receptors to follow the superb example set by the previous volumes in this series by writing compre hensive, historical reviews that will comprise an essential resource for nonspe cialists and newcomers to the dopamine receptor field, while at the same time providing up-to-date summaries of the most active areas of research. It is difficult these days to write about receptors without addressing the issue of receptor nomenclature. For dopamine receptors, valid arguments can be made for a system in which the subtypes are classified as belonging to the Dl or D2 classes, with letters assigned in the order of cloning (D A, D , D A, 1 18 2 D , Dc). We decided, however, that common usage counts for something, and 28 2 chose to use D , D , and D for the D2-like receptors because these names are 2 3 4 nearly unanimously used in the literature.

The Dopamine Receptors

Author : Kim Neve
ISBN : 1603273336
Genre : Medical
File Size : 79. 52 MB
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As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.

The Dopamine Receptors

Author : Kim Neve
ISBN : 9781475726350
Genre : Medical
File Size : 60. 93 MB
Format : PDF
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Seven years after the cloning of the rat dopamine D receptor, and four 2 years after the cloning of the last mammalian dopamine receptor identified to date, this seems to be an excellent time to put together the present The Dopamine Receptors volume ofthis series, The Receptors. There has been time for considerable characterization of the novel receptor subtypes, and new, exciting lines of research from the molecular to the behavioral levels are taking shape. We asked the contributors to The Dopamine Receptors to follow the superb example set by the previous volumes in this series by writing compre hensive, historical reviews that will comprise an essential resource for nonspe cialists and newcomers to the dopamine receptor field, while at the same time providing up-to-date summaries of the most active areas of research. It is difficult these days to write about receptors without addressing the issue of receptor nomenclature. For dopamine receptors, valid arguments can be made for a system in which the subtypes are classified as belonging to the Dl or D2 classes, with letters assigned in the order of cloning (D A, D , D A, 1 18 2 D , Dc). We decided, however, that common usage counts for something, and 28 2 chose to use D , D , and D for the D2-like receptors because these names are 2 3 4 nearly unanimously used in the literature.

The Dopamine Receptors

Author : Kim A. Neve
ISBN : UOM:39015040642731
Genre : Medical
File Size : 27. 42 MB
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A review of dopamine receptor research for those wishing to enter the field as well as those already active in this research area. This volume covers the physiology, biochemistry, molecular biology and pharmacology of these receptors from both the chemical and basic research perspectives.

Dopamine Receptors And Transporters

Author : Anita Sidhu
ISBN : 9780824747428
Genre : Medical
File Size : 20. 53 MB
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"Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."

Dopamine Receptor Subtypes

Author : Peter Jenner
ISBN : 9051992912
Genre : Medical
File Size : 46. 20 MB
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Peripheral Dopaminergic Receptors

Author : Jean Louis
ISBN : 9781483156163
Genre : Nature
File Size : 47. 55 MB
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Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system. This volume is comprised of 36 chapters and opens with a discussion on the dopamine vascular receptor, along with its agonists and antagonists. The reader is then introduced to the physiological and clinical implications of free and conjugated dopamine; dopamine-sensitive adenylate cyclase in the renal artery of dogs; dopamine-induced relaxation of isolated dog arteries; and concentration and function of dopamine in normal and diseased blood vessels. The following chapters explore the possible involvement of endogenous substances in the cardiovascular actions of dopamine; the role of dopamine receptors as mediators of the neurogenic vasodilatation by dopaminergic agents; and implications of renal and adrenal dopamine for the role of conjugated dopamine. Studies on the peripheral cardiovascular activity of dopamine in the rat are also presented. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Neurobiology Of Central D1 Dopamine Receptors

Author : George Breese
ISBN : 9781468451917
Genre : Medical
File Size : 55. 3 MB
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Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.

Dopamine Receptors

Author : Ian Creese
ISBN : UOM:39015012463470
Genre : Dopamine
File Size : 74. 6 MB
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"Dopamine Receptors" precisely chronicles the research being done on dopamine receptors, appraises the techniques and strategies being used, and provides thoughts on future trends. This volume is unique for its multidisciplinary coverage of dopamine receptors, with contributions ranging from physiological and behavioral studies to the biological characterization of dopamine receptors. Examines classifications of receptor subtypes based on ligand binding and adenylate cyclase studies, biochemical analysis, electrophysiological observations and autoradiography. This book also summarizes dopamine receptor involvement in a number of diseases and covers the role of autoreceptors in modulation of dopaminergic systems.

Dopamine

Author : S.B. Dunnett
ISBN : 0080458289
Genre : Medical
File Size : 50. 51 MB
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Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder. This volume of the Handbook of Chemical Neuroanatomy provides a series of in depth critical reviews of our present understanding of the most important aspects of dopamine’s organisation and disturbed function in the animal and human brain.

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