simulated moving bed technology principles design and process applications

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Simulated Moving Bed Technology

Author : Alirio Rodrigues
ISBN : 9780128020517
Genre : Technology & Engineering
File Size : 51. 86 MB
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Simulated Moving Bed Technology is one of only a few books solely dedicated to SMB. It aims to equip you with the tools and skills needed for SMB modelling, simulation, design and operation. The theory presented is supported by real-world examples from the petrochemical, sugar and pharma industries. The core of the book focuses on SMB process development and model validation. It explains basic process concepts and definitions, fundamental principles and equations, as well as typical applications and recent advances made to address challenges. Its specialist content makes it a must have book for people working with SMB technology, chemical engineering post-graduate students and process and R&D engineers in industry. Will provide you with the tools and predictive approaches for use in SMB design and performance assessment Covers SMB modelling, simulation, design and operation as applied to separation and reaction processes Discusses process intensification through coupling SMB and reaction in SMBR, membrane permeation and SMBR in PermSMBR and introduces the design of SCPC

Sorption Enhanced Reaction Processes

Author : Rodrigues Alirio Egidio
ISBN : 9781786343581
Genre : Science
File Size : 27. 18 MB
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New Bioprocessing Strategies Development And Manufacturing Of Recombinant Antibodies And Proteins

Author : Bob Kiss
ISBN : 9783319971100
Genre :
File Size : 29. 16 MB
Format : PDF
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Design Simulation And Optimization Of Adsorptive And Chromatographic Separations A Hands On Approach

Author : Kevin R. Wood
ISBN : 9783527814992
Genre : Science
File Size : 38. 12 MB
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This book allows the reader to effectively design, simulate and optimize adsorptive and chromatographic separations for industrial applications. To achieve this, a unified approach is presented, which develops the ideal and intermediate equations necessary, while simultaneously offering hands-on case studies employing the rigorous simulation packages Aspen Adsorption and Aspen Chromatography. The first part of the book deals with design strategies, detailed design considerations and the assumptions, which the models are allowed to make and covers shortcut design methods as well as mathematical tools to determine optimal operating conditions. These insights are used in Chapter 4 & 5 to estimate and optimize performance parameters, such as purity, recovery, etc. as well as the regression of these parameters.

Scale Up And Optimization In Preparative Chromatography

Author : Anurag Rathore
ISBN : 0203909283
Genre : Science
File Size : 60. 37 MB
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Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; data comparisons from all stages of production; and industrial separation schemes for products such as synthetic molecules, antibody fragments, IgG, growth factors, and plasmid DNA. The book covers external constraints, separation economics, correlations for transport and kinetic phenomena, and the configuration and parameters of column design.

Separation And Purification Technologies In Biorefineries

Author : Shri Ramaswamy
ISBN : 9781118493465
Genre : Science
File Size : 70. 34 MB
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Separation and purification processes play a critical role in biorefineries and their optimal selection, design and operation to maximise product yields and improve overall process efficiency. Separations and purifications are necessary for upstream processes as well as in maximising and improving product recovery in downstream processes. These processes account for a significant fraction of the total capital and operating costs and also are highly energy intensive. Consequently, a better understanding of separation and purification processes, current and possible alternative and novel advanced methods is essential for achieving the overall techno-economic feasibility and commercial success of sustainable biorefineries. This book presents a comprehensive overview focused specifically on the present state, future challenges and opportunities for separation and purification methods and technologies in biorefineries. Topics covered include: Equilibrium Separations: Distillation, liquid-liquid extraction and supercritical fluid extraction. Affinity-Based Separations: Adsorption, ion exchange, and simulated moving bed technologies. Membrane Based Separations: Microfiltration, ultrafiltration and diafiltration, nanofiltration, membrane pervaporation, and membrane distillation. Solid-liquid Separations: Conventional filtration and solid-liquid extraction. Hybrid/Integrated Reaction-Separation Systems: Membrane bioreactors, extractive fermentation, reactive distillation and reactive absorption. For each of these processes, the fundamental principles and design aspects are presented, followed by a detailed discussion and specific examples of applications in biorefineries. Each chapter also considers the market needs, industrial challenges, future opportunities, and economic importance of the separation and purification methods. The book concludes with a series of detailed case studies including cellulosic bioethanol production, extraction of algae oil from microalgae, and production of biopolymers. Separation and Purification Technologies in Biorefineries is an essential resource for scientists and engineers, as well as researchers and academics working in the broader conventional and emerging bio-based products industry, including biomaterials, biochemicals, biofuels and bioenergy.

Continuous Processing In Pharmaceutical Manufacturing

Author : Ganapathy Subramanian
ISBN : 9783527673704
Genre : Medical
File Size : 81. 50 MB
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With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.

Integrated Reaction And Separation Operations

Author : Henner Schmidt-Traub
ISBN : 3540303049
Genre : Science
File Size : 48. 74 MB
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Economic needs as well as ecological demands are major driving forces in improving chemical processes and plants. To meet these goals processes have to be intensified in order to get products of higher quality, to increase yield by reducing or even suppressing by-products and to minimise energy consumption. A preferred principle for such intensifications is process - tegration, especially integration of reaction and separation operations. S- entific research in this field has been boosted by certain extremely succe- ful examples like the Eastman-Kodak process for methyl acetate or the MTBE process which are milestones for this method. In 2002 the German Research Foundation defined process integration as one of the major - search topics for the next decade. In 1998 the Department of Biochemical- and Chemical Engineering at the University of Dortmund decided to pool its activities for concerted - forts in process integration and to form a joint research cluster. Our interest was to find out the general challenges as well as obstacles of integrated processes and to work out methods for their design and valuation. Soon it became clear that theoretical work only cannot give reasonable answers.

Handbook Of Bioseparations

Author : Satinder Ahuja
ISBN : 0080507794
Genre : Technology & Engineering
File Size : 54. 20 MB
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It is generally recognized that the commercial success of biotechnology products is highly dependent on the successful development and application of high-powered separation and purification methods. In this practical and authoritative handbook, the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also included in a chapter on the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography are covered at length. Regulatory and economic considerations are addressed, as are plant and process equipment and engineering process control. A chapter on future developments highlights the application of DNA chip arrays as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer's disease. Handbook of Bioseparations serves as an essential reference and guidebook for separation scientists working in the pharmaceutical and biotechnology industries, academia, and government laboratories. Key Features * Covers bioseparations of proteins, nucleic acids, and monoclonal antibodies * Encompasses both analytical and process-scale methods * Elucidates the importance of engineering process control * Details selection of plant and process equipment * Addresses economic considerations * Discusses future developments

The Simulated Countercurrent Moving Bed Chromatographic Reactor

Author : Ajay Kumar Ray
ISBN : MINN:31951D00754367K
Genre :
File Size : 79. 6 MB
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