practical synthetic organic chemistry reactions principles and techniques

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Practical Synthetic Organic Chemistry

Author : Stéphane Caron
ISBN : 9781118093566
Genre : Science
File Size : 53. 6 MB
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A hands-on guide to assist in the planning and execution ofsynthetic reactions in the laboratory Despite the maturity of organic chemistry, it can still be verychallenging to identify optimal methods for synthetictransformations that perform as well in real-world manufacturingprocesses as they do in the laboratory. This detailed andaccessible guide attempts to address this vexing issue and deliverproven methodologies practicing synthetic chemists will findvaluable for identifying reaction conditions that work reliablyover the broadest possible range of substrates. Practical Synthetic Organic Chemistry: Provides a practical guide to strategically planning andexecuting chemical syntheses for the bench chemist in industry Discusses information that is not common knowledge beyond theboundaries of process chemistry groups, such as the syntheticroutes of selected contemporary pharmaceutical drugs and practicalsolvents, as well as green chemistry concepts Highlights key reactions, including substitutions, additions,eliminations, rearrangements, oxidations, and reductions Addresses basic principles, mechanisms, advantages anddisadvantages of the methodology, and techniques for achievinglaboratory success Incorporating such an extraordinary wealth of information onorganic chemistry and its related fields into one complete volumedistinguishes Practical Synthetic Organic Chemistry as anincomparable desktop reference for professionals—and aninvaluable study aid for students.

Practical Synthetic Organic Chemistry

Author : Stéphane Caron
ISBN : 9780470037331
Genre : Science
File Size : 59. 41 MB
Format : PDF
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"This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory"--Provided by publisher.

Practical Synthetic Organic Chemistry

Author : Stéphane Caron
ISBN : 9780470037331
Genre : Science
File Size : 88. 11 MB
Format : PDF, Docs
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"This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory"--Provided by publisher.

Early Drug Development

Author : Fabrizio Giordanetto
ISBN : 9783527801770
Genre : Science
File Size : 58. 32 MB
Format : PDF
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This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Practical Process Research And Development A Guide For Organic Chemists

Author : Neal G. Anderson
ISBN : 9780123865380
Genre : Science
File Size : 35. 27 MB
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Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Advances In Organometallic Chemistry

Author : Pedro J. Pérez
ISBN : 9780128029572
Genre : Science
File Size : 57. 55 MB
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Advances in Organometallic Chemistry contains authoritative reviews on the field of organometallic chemistry, covering topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. The book will benefit a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies, and practical applications. Contains contributions from leading authorities in the field of organometallic chemistry Covers topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Informs and updates readers on all the latest developments in the field Carefully edited to provide easy-to-read material

Organische Chemie

Author : Jonathan Clayden
ISBN : 3642347150
Genre : Science
File Size : 89. 68 MB
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Ein neuer Stern am Lehrbuch-Himmel: Organische Chemie von Clayden, Greeves, Warren - der ideale Begleiter für alle Chemiestudenten. Der Schwerpunkt dieses didaktisch durchdachten, umfassenden vierfarbigen Lehrbuches liegt auf dem Verständnis von Mechanismen, Strukturen und Prozessen, nicht auf dem Lernen von Fakten. Organische Chemie entpuppt sich als dabei als ein kohärentes Ganzes, mit zahlreichen logischen Verbindungen und Konsequenzen sowie einer grundlegenden Struktur und Sprache. Dank der Betonung von Reaktionsmechanismen, Orbitalen und Stereochemie gewinnen die Studierenden ein solides Verständnis der wichtigsten Faktoren, die für alle organisch-chemischen Reaktionen gelten. So lernen sie, auch Reaktionen, die ihnen bisher unbekannt waren, zu interpretieren und ihren Ablauf vorherzusagen. Der direkte, persönliche, studentenfreundliche Schreibstil motiviert die Leser, mehr erfahren zu wollen. Umfangreiche Online-Materialien führen das Lernen über das gedruckte Buch hinaus und vertiefen das Verständnis noch weiter.

Organomagnesium Methods In Organic Chemistry

Author : Basil J. Wakefield
ISBN : 0080538177
Genre : Science
File Size : 49. 7 MB
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The book opens with a general overview of the constitution and reactivity of organomagnesium compounds, followed by information on handling them and on their detection and estimation. Throughout, practical aspects aswell as principles are emphasized. The chapters on the synthesis of organomagnesium compounds cover the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes, as well as the traditional preparation of Grignard reagents. Preparations by metallation and metal-halogen exchanges are also included, as are newer methods such as hydromagnesiation of alkenes and alkynes. Systematic coverage is provided on synthetically useful reactions of organomagnesium compounds. Of fundamental importance in organic synthesis are carbon-carbon bond forming reactions; additions to carbon-carbon, carbon-nitrogen, carbon-oxygen, and carbon-sulfur multiple bonds; and nucleophilic substitution at carbon. The formation of carbon-heteroatom bonds in organic compounds is described, where the heteroatom is hydrogen, nitrogen, oxygen, sulfur, or halogen. Finally, the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds is outlined. Representative experimental procedures are included throughout the book, and tables with references to well-described examples are provided. Presents a general overview of the constitution and reactivity of organomagnesium compounds Provides coverage on the detection and estimation of organomagnesium compounds Emphasizes practical aspects as well as principles Covers the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes Includes preparations by metallation and metal-halogen exchanges Reviews new preparation methods such as hydromagnesiation of alkenes and alkynes Outlines information on synthetically useful reactions of organomagnesium compounds Describes the formation of carbon-heteroatom bonds in organic compounds Addresses the use of organomagnesium compounds in preparing other organometalloid and organometallic compounds Includes representative procedures and tables with references to well-described examples

Experimental Organic Chemistry

Author : Philippa B. Cranwell
ISBN : 9781119952381
Genre : Science
File Size : 74. 33 MB
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Previous edition by Laurence M. Harwood, Christopher J. Moody, and Jonathan M. Percy.

Organic Photochemistry

Author : Jacques Kagan
ISBN : 9780080984414
Genre : Science
File Size : 33. 56 MB
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Organic Photochemistry outlines the principles, techniques and well-known reactions occurring in organic molecules and also illustrates more complex photochemical transformations occurring in organic chemistry. Many photochemical transformations convert simple molecules into extremely complex products with an ease not approached by the standard synthetic chemistry practiced in the laboratory. In the earlier chapters, the author outlines the principles, techniques and some of the well-known reactions occurring in organic molecules and later illustrates more complex photochemical transformations occuring in organic chemistry. Experimental techniques are included to encourage novices. Topics are emphasized where structural transformations can be formulated chemically. Practical applications are collected together. The book starts at a comfortably simple level with enough examples to provide an introduction to the diversity of photochemical reactions. * Includes experimental techniques to encourage novices. * Emphasizes topics where structural transformations can be formulated chemically * Collects and presents practical applications * Written in a simple style including enough examples to serve as an introduction to the diversity of photochemical reactions

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