physiological basis of aging and geriatrics fourth edition

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Extensively revised and updated to reflect the current state of knowledge in the study of aging, this Fourth Edition offers a complete profile of the aging process at all levels, from molecules and cells to demography and evolution. Written by international experts in current basic and clinical aging research, this text includes aspects of individual, comparative, and differential aging, and discussions of theories and mechanisms of aging. This invaluable reference illustrates how bodily systems, organs, and functions are affected with aging, describes how genetic and environmental factors influence age-related changes, and addresses some of the clinical consequences of these changes for health and longevity. Well illustrated, with numerous tables and graphs, this book presents up-to-date information from internationally renowned experts in various bio-medical fields. New updated information includes: emphasis on emerging technologies and recent advances in biology and bioengineering that allow greater and longer independence of the elderly recent therapeutic developments in key diseases such as Alzheimer's, osteopenia, osteoporosis, high cholesterol, diabetes, gastritis, sexual impotence, and using transgenic animals as models of aging evaluation of the latest knowledge on the roles of oxidants and antioxidants, and correlates them with other aging-based theories expanded discussion of nutrition and physical exercise chapters on gene and stem cell interventions related to the aging process updated tables to reflect current trends, new research data, and up-to-date statistical information

Targeting the key active elements in the mechanism and application of apoptosis and its therapeutic implications, Apoptosis: Modern Insights into Disease from Molecules to Man covers apoptosis from A to Z. Comprehensive in scope, it explores a wide range of topics including various cancers, asthma, and multiple sclerosis as well as alcohol induced liver disease, chronic back pain, and cardiovascular health. With 40 chapters written by highly respected authorities, this single source reference provides researchers and scientists with the foundation they need.

Best of Five MCQs for the Acute Medicine SCE is a new revision resource designed specifically for this high-stakes exam. Containing over 350 Best of Five multiple choice questions, this dedicated guide will help candidates to prepare successfully. The content mirrors the SCE in Acute Medicine Blueprint to ensure candidates are fully prepared for all the topics that may appear in the exam. Topics range from how to manage acute problems in cardiology or neurology to managing acute conditions such as poisoning. All answers have full explanations and further reading to ensure high quality self-assessment and quick recognition of areas that require further study.

Established as a standard basic science text for surgeons and for residents preparing for the board exam, this authoritative text is written by renowned educators with experience preparing surgical residency curricula. The book presents complex physiologic concepts clearly, with numerous illustrations.

Epidemiology of Aging: An Ecological Approach is the first title to provide a comprehensive overview of the leading topics in the epidemiology of aging, such as physical functioning, depression, and survival with the ecological model. Using this ecological model, the author highlights the causes and consequences of the aging population and illustrates that all the topics are interrelated.

Praise for the Third Edition: "In this comprehensive textbook on palliative care nursing, editors Marianne Matzo and Deborah Witt Sherman succeed in bringing together the heart of nursing and the true meaning of palliative care with the most current evidence based practice." --GeriPal This fourth edition of a comprehensive text/reference that has been valued by students, educators, and practicing nurses for many years, Palliative Care Nursing continues to reflect the fundamental hospice and palliative care nursing competencies---both basic and advanced--that are essential for effective and empathetic care of patients and families. This new edition reflects the tremendous growth of this vital discipline into the mainstream of health care and focuses on palliative care that is responsive to the demand for health care reform in America and globally. It provides the knowledge, scientific evidence, and skills needed by nurses to address the complex physical, emotional, social, sexual, and spiritual needs of patients and families within the context of a changing health care delivery system. With a focus on inter-professional collaboration, the book emphasizes the value of complementary, holistic models in promoting health and wholeness across the illness trajectory, even as death approaches. The book is edited by Project on Death in America Faculty Scholars, who have worked to develop, implement, and evaluate nursing initiatives in palliative care in the U.S. and internationally. With a focus on both quality of life and economic imperatives, interdisciplinary authors describe the management of specific diseases and related physical and psychological symptoms, and care of patients during the dying process. They cover assessment of key symptoms and pharmacological, non-pharmacological, and complementary interventions. Taking a life-span approach, the book includes age-appropriate nursing considerations. Key points at the beginning of each chapter and callouts containing evidenced-based information highlight best practices. The text also examines relevant legal, ethical, and cultural considerations and offers case studies with conclusions in each clinical chapter. New to the Fourth Edition: Thoroughly revised and expanded Three new chapters addressing palliative care amidst health care reform, rehabilitation in chronic or serious illness, and post-traumatic stress disorder A conceptual framework table in each chapter identifying the National Quality Forum Domains of Palliative Care and Basic and Advanced Palliative Care and Hospice Nursing Competencies Updated evidence-based callouts that review the highest-quality studies

Combines basic science with practical clinical perspectives. This reference describes in detail the effects of ageing on the respiratory system, and presents the diseases that may develop in the elderly individual, including chronic obstructive pulmonary disease, lung cancer and pneumonia.

Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging. Methuselah Flies: is a tightly edited distillation of twenty years of work by many scientists; contains the original publications regarding the longer-lived fruit flies; offers commentaries on each of the topics covered - new, short essays that put the individual research papers in a wider context; gives full access to the original data; captures the scientific significance of postponed aging for a wide academic audience.

This unique book provides a concise account, written by world authorities in their fields, of how the mammalian lung grows and matures before birth and how the lungs, and their ability to function well, can be affected by the environment and by genetic factors, both before and after birth. It provides an understanding of the basis of some major lung diseases affecting infants and children. The book also deals with how the lung changes with age, and how the process of lung aging can be affected by the environment. * Discusses the mechanisms that regulate the initial events of lung morphogenesis * Provides a better understanding of the cellular and biochemical events involved in alveolarization * Development of the pulmonary immune system and how the exposure to allergens during development may lead to diseases such as asthma

In Endocrinology of Aging, a panel of distinguished physicians critically reviews the clinical consequences of the endocrinological changes that occur with aging-in both men and women-and examine the use of hormonal therapy to reduce them. Topics range from bone disease and water balance in all older people, to androgen deficiency in aging males, gynecomastia, and menopause. The authors also discuss Type II diabetes in persons over 65, emphasizing the cognitive benefits of good glycemia control, and the interaction of nutrition and metabolism, focusing on hypocholesterolemia, obesity, the anorexia of aging, trace elements, and vitamins. The aging of the sympathetic nervous system and its impact on hypertension in the elderly is also covered. Timely and authoritative, Endocrinology of Aging offers endocrinologists, geriatricians, and primary care physicians critical insight into the endocrine problems of our rapidly growing elderly population. The valuable information here will greatly augment every physician's ability to enhance function in their aging patients by insightful application of modern treatment regimes and today's powerful new therapeutics.

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