physicochemical principles of pharmacy in manufacture formulation and clinical use

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Physicochemical Principles Of Pharmacy

Author : Alexander T Florence
ISBN : 9780857111746
Genre : Medical
File Size : 55. 55 MB
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This 6th edition of the established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body.

Physicochemical Principles Of Pharmacy

Author : Alexander Taylor Florence
ISBN : 9780853699842
Genre : Medical
File Size : 90. 5 MB
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This well-known textbook uses pharmaceutical examples to illustrate the underlying physical chemistry of drug delivery, characterisation, formulation, transport and absorption.

Physicochemical Principles Of Pharmacy

Author : Alexander Taylor Florence
ISBN : 085369608X
Genre : Medical
File Size : 23. 34 MB
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Physical chemistry is the basis of rational pharmaceutical formulation and processing, and is fundamental to understanding the complexities of drug delivery and drug absorption. This book provides the physicochemical background to the design and use of pharmaceutical dosage forms. It goes beyond the introductory aspects of the subject to show how basic physicochemical principles are essential to the understanding of every aspect of drug action, from the dosage form to the site of action in the body. the fourth edition of this well established textbook has been thoroughly revised and re-structu

Aulton S Pharmaceutics

Author : Michael E. Aulton
ISBN : 9780702042904
Genre : Medical
File Size : 51. 87 MB
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Pharmaceutics is one of the most diverse subject areas in all of pharmaceutical science. In brief, it is concerned with the scientific and technological aspects of the design and manufacture of dosage forms or medicines. An understanding of pharmaceutics is therefore vital for all pharmacists and those pharmaceutical scientists who are involved with converting a drug or a potential drug into a medicine that can be delivered safely, effectively and conveniently to the patient. Now in its fourth edition, this best-selling textbook in pharmaceutics has been brought completely up to date to reflect the rapid advances in delivery methodologies by eye and injection, advances in drug formulations and delivery methods for special groups (such as children and the elderly), nanomedicine, and pharmacognosy. At the same time the editors have striven to maintain the accessibility of the text for students of pharmacy, preserving the balance between being a suitably pitched introductory text and a clear reflection of the state of the art. provides a logical, comprehensive account of drug design and manufacture includes the science of formulation and drug delivery designed and written for newcomers to the design of dosage forms New to this edition New editor: Kevin Taylor, Professor of Clinical Pharmaceutics, School of Pharmacy, University of London. Twenty-two new contributors. Six new chapters covering parenteral and ocular delivery; design and administration of medicines for the children and elderly; the latest in plant medicines; nanotechnology and nanomedicines, and the delivery of biopharmaceuticals. Thoroughly revised and updated throughout.

Developing Solid Oral Dosage Forms

Author : Yihong Qiu
ISBN : 008093272X
Genre : Medical
File Size : 23. 97 MB
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Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies

Pharmacogenomics

Author : Yui-Wing Francis Lam
ISBN : 9780123983039
Genre : Medical
File Size : 75. 19 MB
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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Physical Pharmacy

Author : David Attwood
ISBN : 0853697256
Genre : Medical
File Size : 81. 37 MB
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FASTtrack is a new series of indispensable revision guides created especially for undergraduate pharmacy students. the FASTtrack series provides the ultimate lecture notes and is a must-have for all pharmacy undergraduate students wanting to revise and test themselves for forthcoming exams. Based on the successful textbook, Physicochemical Principles of Pharmacy, this title is a concise guide providing the physicochemical background to the design and use of pharmaceutical dosage forms.

Advanced Pharmaceutics

Author : Cherng-ju Kim
ISBN : 0203492919
Genre : Medical
File Size : 55. 39 MB
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Discussing a comprehensive range of topics, Advanced Pharmaceutics: Physicochemical Principles reviews all aspects of physical pharmacy. The book explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical pharmacy related problems. The author supplies a strong fundamental background and extensively covers thermodynamics, ionic equilibria, solutions and distribution, surface chemistry and colloids, kinetics, diffusion, and polymer science. He outlines the latest research on diffusion through a membrane and the use of polymers in dosage forms. Packed with formulae and models, the book demonstrates the development of each and then describes the use of those models for a variety of formulation situations. The author's detailed explanation of the evolution of the formulae provides a clear understanding of when and how they are used. This bottom-up approach delineates the evolution of the formulae and gives a clear understanding of when and how they should be used. The book provides an in-depth review and analysis of dosage form design criteria that you can rapidly implement in your day-to-day work.

Pharmaceutics

Author : Alekha Dash
ISBN : 9780123868916
Genre : Medical
File Size : 49. 30 MB
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Pharmaceutics: Basic Principles and Application to Pharmacy Practice is an engaging textbook that covers all aspects of pharmaceutics with emphasis on the basic science and its application to pharmacy practice. Based on curricular guidelines mandated by the American Council for Pharmacy Education (ACPE), this book incorporates laboratory skills by identifying portions of each principle that can be used in a clinical setting. In this way, instructors are able to demonstrate their adherence to ACPE standards and objectives, simply by using this book. Written in a straightforward and student-friendly manner, Pharmaceutics enables students to gain the scientific foundation to understand drug physicochemical properties, practical aspects of dosage forms and drug delivery systems, and the biological applications of drug administration. Key ideas are illustrated and reinforced through chapter objectives and chapter summaries. A companion website features resources for students and instructors, including videos illustrating difficult processes and procedures as well as practice questions and answers. Instructor resources include Powerpoint slides and a full-color image bank. This book is intended for students in pharmaceutical science programs taking pharmaceutics or biopharmaceutics courses at the undergraduate, graduate and doctoral level. Chapter objectives and chapter summaries illustrate and reinforce key ideas Designed to meet curricular guidelines for pharmaceutics and laboratory skills mandated by the Accreditation Council for Pharmacy Education (ACPE) Companion website features resources for students and instructors, including videos illustrating difficult processes and procedures and practice questions and answers. Instructor resources include Powerpoint slides and a full-color image bank

Pharmaceutical Suspensions

Author : Alok K. Kulshreshtha
ISBN : 1441910875
Genre : Medical
File Size : 42. 63 MB
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The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

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