physicochemical and biomimetic properties in drug discovery enhanced edition chromatographic techniques for lead optimization

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Physicochemical And Biomimetic Properties In Drug Discovery

Author : Klara Valko
ISBN : 9781118770412
Genre : Medical
File Size : 35. 36 MB
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Physicochemical And Biomimetic Properties In Drug Discovery

Author : Klara Valko
ISBN : 1118152123
Genre : Medical
File Size : 60. 68 MB
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Explains how to take full advantage of chromatography to find successful drug candidates Based on a course taught by the author for many years, this book demonstrates how to use chromatography to measure the physicochemical and biomimetic properties of drug candidates in the early stages of drug discovery in order to fully optimize drug leads. Readers will learn how to interpret chromatographic retention data using various models in order to estimate the "in vivo" distribution behavior of drugs. The property data obtained by these chromatographic measurements can then be used to select and prioritize compounds for further "in vitro" and "in vivo" studies at the early stages of the drug discovery process. "Physicochemical and Biomimetic Properties in Drug Discovery" provides clear explanations and guidance to facilitate reproduction of the chromatographic measurements discussed in the book in any laboratory equipped with HPLC. It begins with a quick review of the drug discovery process. Next, it covers: Drug-likeness and the physicochemical property space of known drugs Basic pharmacokinetic properties Principles and methods of chromatography for the application of property measurements Molecular physicochemical properties that influence absorption and distribution: lipophilicity, solubility, permeability, and acid dissociation constant (p"K"a) Models with measured physicochemical and biomimetic chromatographic descriptors: absorption, distribution, and drug efficiency The final chapter is dedicated to applications and examples of the use of chromatography in drug discovery. Throughout the book, real-life examples demonstrate how to optimize the use of chromatography to obtain successful drug candidates. Each chapter concludes with a series of questions, with answers in the appendix, making this book ideal for students as well as researchers in drug discovery.

Quantitative Structure Chromatographic Retention Relationships

Author : Roman Kaliszan
ISBN : UOM:39015016088331
Genre : Science
File Size : 38. 78 MB
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The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.

Plant Bioactives And Drug Discovery

Author : Valdir Cechinel-Filho
ISBN : 9781118259924
Genre : Science
File Size : 59. 84 MB
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An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Drug Metabolism In Drug Design And Development

Author : Donglu Zhang
ISBN : 0470191686
Genre : Science
File Size : 72. 8 MB
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The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Tea In Health And Disease Prevention

Author : Victor R. Preedy
ISBN : 9780123849380
Genre : Technology & Engineering
File Size : 62. 14 MB
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While there have been many claims of the benefits of teas through the years, and while there is nearly universal agreement that drinking tea can benefit health, there is still a concern over whether the lab-generated results are representative of real-life benefit, what the risk of toxicity might be, and what the effective-level thresholds are for various purposes. Clearly there are still questions about the efficacy and use of tea for health benefit. This book presents a comprehensive look at the compounds in black, green, and white teas, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses. No other book on the market considers all the varieties of teas in one volume, or takes the disease-focused approach that will assist in directing further research and studies. Interdisciplinary presentation of material assists in identifying potential cross-over benefits and similarities between tea sources and diseases Assists in identifying therapeutic benefits for new product development Includes coverage and comparison of the most important types of tea - green, black and white

Physico Chemical Methods In Drug Discovery And Development

Author : Zoran Mandic
ISBN : 9789535694205
Genre :
File Size : 24. 72 MB
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Platform Technologies In Drug Discovery And Validation

Author :
ISBN : 9780128130704
Genre : Medical
File Size : 69. 58 MB
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Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

40 Days Of Dating

Author : Timothy Goodman
ISBN : 9781613127155
Genre : Self-Help
File Size : 32. 42 MB
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“What would happen if Harry met Sally in the age of Tinder and Snapchat? . . . A field guide to Millennial dating in New York City” (New York Daily News). When New York–based graphic designers and long-time friends Timothy Goodman and Jessica Walsh found themselves single at the same time, they decided to try an experiment. The old adage says that it takes 40 days to change a habit—could the same be said for love? So they agreed to date each other for 40 days, record their experiences in questionnaires, photographs, videos, texts, and artworks, and post the material on a website they would create for this purpose. What began as a small experiment between two friends became an Internet sensation, drawing 5 million unique (and obsessed) visitors from around the globe to their site and their story. 40 Days of Dating: An Experiment is a beautifully designed, expanded look at the experiment and the results, including a great deal of material that never made it onto the site, such as who they were as friends and individuals before the 40 days and who they have become since.

Absorption And Drug Development

Author : Alex Avdeef
ISBN : 0471450251
Genre : Science
File Size : 33. 16 MB
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