physicochemical and biomimetic properties in drug discovery chromatographic techniques for lead optimization

Download Book Physicochemical And Biomimetic Properties In Drug Discovery Chromatographic Techniques For Lead Optimization in PDF format. You can Read Online Physicochemical And Biomimetic Properties In Drug Discovery Chromatographic Techniques For Lead Optimization here in PDF, EPUB, Mobi or Docx formats.

Physicochemical And Biomimetic Properties In Drug Discovery

Author : Klara Valko
ISBN : 9781118770320
Genre : Medical
File Size : 72. 37 MB
Format : PDF, ePub, Docs
Download : 870
Read : 989

Download Now


Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

Drug Bioavailability

Author : Han van de Waterbeemd
ISBN : 9783527605156
Genre : Science
File Size : 64. 54 MB
Format : PDF, ePub
Download : 774
Read : 208

Download Now


The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Pharmaceutical Profiling In Drug Discovery For Lead Selection

Author : Ronald Borchardt
ISBN : 0971176795
Genre : Medical
File Size : 75. 55 MB
Format : PDF
Download : 989
Read : 362

Download Now


This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Comprehensive Dissertation Index

Author :
ISBN : UOM:39015065693528
Genre : Dissertations, Academic
File Size : 51. 48 MB
Format : PDF, ePub, Mobi
Download : 144
Read : 628

Download Now



Issues In Chemical Engineering And Other Chemistry Specialties 2011 Edition

Author :
ISBN : 9781464963551
Genre : Technology & Engineering
File Size : 51. 18 MB
Format : PDF
Download : 482
Read : 1153

Download Now


Issues in Chemical Engineering and other Chemistry Specialties: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemical Engineering and other Chemistry Specialties. The editors have built Issues in Chemical Engineering and other Chemistry Specialties: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chemical Engineering and other Chemistry Specialties in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemical Engineering and other Chemistry Specialties: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Top Download:

Best Books