phosphodiesterase inhibitors handbook of immunopharmacology

Download Book Phosphodiesterase Inhibitors Handbook Of Immunopharmacology in PDF format. You can Read Online Phosphodiesterase Inhibitors Handbook Of Immunopharmacology here in PDF, EPUB, Mobi or Docx formats.

High Throughput Screening For Novel Anti Inflammatories

Author : Michael Kahn
ISBN : 9783034884624
Genre : Science
File Size : 23. 76 MB
Format : PDF, ePub, Mobi
Download : 786
Read : 1270

Download Now


Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

Drug Discovery And Evaluation Pharmacological Assays

Author : Hans Vogel
ISBN : 9783540714200
Genre : Medical
File Size : 63. 33 MB
Format : PDF, Mobi
Download : 111
Read : 494

Download Now


The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Phosphodiesterase Inhibitors

Author :
ISBN : 9780080538815
Genre : Science
File Size : 85. 48 MB
Format : PDF, Mobi
Download : 818
Read : 337

Download Now


Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike

Methylxanthines

Author : Bertil B. Fredholm
ISBN : 3642134432
Genre : Medical
File Size : 87. 13 MB
Format : PDF
Download : 526
Read : 648

Download Now


In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.

Science Of Synthesis Houben Weyl Methods Of Molecular Transformations Vol 16

Author :
ISBN : 9783131780713
Genre : Science
File Size : 63. 49 MB
Format : PDF, ePub, Mobi
Download : 474
Read : 205

Download Now


Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in December 2003.

Phosphodiesterase Inhibitors

Author : Christian Schudt
ISBN : 9780122107207
Genre : Medical
File Size : 37. 77 MB
Format : PDF, Mobi
Download : 219
Read : 553

Download Now


Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Key Features * Utilizes actual testing and research of new PDE inhibitors * Valuable for researchers and students alike

Chemogenomics

Author : Edgar Jacoby
ISBN : UOM:39015075683295
Genre : Science
File Size : 29. 10 MB
Format : PDF, ePub
Download : 522
Read : 564

Download Now


The establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular Biology™ series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.

Asthma Physiology Immunopharmacology And Treatment

Author : Stephen T. Holgate
ISBN : UOM:39015009124317
Genre : Medical
File Size : 23. 51 MB
Format : PDF
Download : 178
Read : 1042

Download Now



Immunopharmacology Of The Microcirculation

Author : Susan D. Brain
ISBN : UOM:39015032450911
Genre : Medical
File Size : 80. 79 MB
Format : PDF, ePub
Download : 490
Read : 1213

Download Now


The sum of a range of imflammatory events at the microvascular level leads to the expression of one of many inflammatory diseases. The microcirculation is a target for existing and potential anti-inflammatory therapies and it is anticipated that a greater knowledge of the immunopharmacology of the microcirculation will lead to novel therapeutic targets. This volume covers examples of these imflammatory diseases, the in vitro and in vivo techniques used to study them, and the therapeutic agents used to combat them.

The Journal Of Respiratory Diseases

Author :
ISBN : NWU:35558003868698
Genre : Respiratory organs
File Size : 47. 76 MB
Format : PDF, ePub, Mobi
Download : 967
Read : 1152

Download Now



Top Download:

Best Books