pharmaceutical experimental design

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Pharmaceutical Experimental Design

Author : Gareth A. Lewis
ISBN : 9780824746889
Genre : Mathematics
File Size : 70. 13 MB
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This useful reference describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process-including preformulation, formulation, process study and optimization, scale-up, and robust process and formulation development.Shows how to overcome pharmaceutical, technological, and economic constraints on experiment design!Directly comparing the advantages and disadvantages of specific techniques, Pharmaceutical Experimental Design· offers broad, detailed, up-to-date descriptions of designs and methods not easily accessible in other books· reviews screening designs for qualitative factors at different levels· presents designs for predictive models and their use in optimization· highlights optimization methods, such as steepest ascent, optimum path, canonical analysis, graphical analysis, and desirability· discusses the Taguchi method for quality assurance and approaches for robust scaling up and process transfer· details nonstandard designs and mixtures· analyzes factorial, D-optimal design, and offline quality assurance techniques· reveals how one experimental design evolves from another· and more!Featuring over 700 references, tables, equations, and drawings, Pharmaceutical Experimental Design is suitable for industrial, research, and clinical pharmaceutical scientists, pharmacists, and pharmacologists; statisticians and biostatisticians; drug regulatory affairs personnel; biotechnologists; formulation, analytical, and synthetic chemists and engineers, quality assurance personnel; all users of statistical experimental design in research and development; and postgraduate and postdoctoral research workers in these disciplines.

Pharmaceutical Experimental Design And Interpretation

Author : N. Anthony Armstrong
ISBN : 020348309X
Genre : Medical
File Size : 39. 58 MB
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This work provides a description of the principles of experimental design and their application to pharmaceutical research. It includes worked examples taken from a wide variety of pharmaceutical techniques and processes.

Pharmaceutical Experimental Design And Interpretation Second Edition

Author : N. Anthony Armstrong
ISBN : 0415299012
Genre : Medical
File Size : 58. 33 MB
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Completely revised and updated, Pharmaceutical Experimental Design and Interpretation, Second Edition explains the major methods of experimental design and evaluation such as multivariate, sequential, and principal components analysis. With new sections on neural networks, artificial intelligence, fractional designs, and optimization techniques, this source will prove invaluable to anyone involved in the design and execution of pharmaceutical research studies and the interpretation of study data.

Pharmaceutical And Medical Device Validation By Experimental Design

Author : Lynn D Torbeck
ISBN : 1420055704
Genre : Medical
File Size : 69. 69 MB
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This title demonstrates how designed experiments are the most scientific, efficient, and cost effective method of data collection for validation in a laboratory setting. Intended as a learn-by-example guide, Pharmaceutical and Medical Device Validation by Experimental Design demonstrates why designed experiments are the most logical and rational approach to use, using realistic case studies, illustrations, and where appropriate, step-by-step protocols and procedures.

Design And Analysis Of Animal Studies In Pharmaceutical Development

Author : Shein-Chung Chow
ISBN : 0824701305
Genre : Mathematics
File Size : 67. 88 MB
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"Provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development. Demonstrates the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products and clarifies detailed presentations with real-world examples. "

Nuclear Medicine In Pharmaceutical Research

Author : M. Frier
ISBN : 9780748406883
Genre : Medical
File Size : 59. 94 MB
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This text defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, giving information from clinical trial data.

Computer Aided Applications In Pharmaceutical Technology

Author : Jelena Djuris
ISBN : 9781908818324
Genre : Medical
File Size : 37. 37 MB
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Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

Colloid And Interface Science In Pharmaceutical Research And Development

Author : Hiroyuki Ohshima
ISBN : 9780444626080
Genre : Technology & Engineering
File Size : 30. 36 MB
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Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development Explains the physicochemical/colloidal basis of pharmaceutical science Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

The Science And Clinical Application Of Manual Therapy E Book

Author : Hollis H. King
ISBN : 9780702049958
Genre : Medical
File Size : 83. 55 MB
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The Science and Clinical Application of Manual Therapy is a multi-disciplinary, international reference book based on work by the top basic science researchers and clinical researchers in the area of Manual Therapy and Manual Medicine (MT/MM). The first book to bring together research on the benefits of MT/MM beyond the known effects on musculoskeletal disorders, it presents evidence of the benefit of MT/MM in treating systemic disorders such as asthma, heart rate dysfunction and GI disturbance. Authored by the leading multidisciplinary basic science and clinical researchers from throughout the world Describes research confirming benefit of MT for musculoskeletal disorders (which helps provide a rational for greater utilization of manual therapy and reimbursement for this healthcare service) Presents the latest findings on the beneficial effect of MT on systemic disorders including asthma, pneumonia, otitis media, heart rate dysfunction and GI disturbance Critically assesses longstanding theoretical models of MT/MM mechanisms with respect to the current understanding of physiological and neurophysiological function Explores the influences of psychological and cortical processes on the effects of MT/MM, including the effect of placebo Uniquely presents research findings from all the manual therapy professions and scientists making the case for the benefits of MT The symposium from which the book was derived was supported by the NIH National Center for Complimentary and Alternative Medicine

Research Methods For Pharmaceutical Practice And Policy

Author : Rajender R. Aparasu
ISBN : 9780853698807
Genre : Medical
File Size : 28. 63 MB
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This text provides the theory and practice for conducting pharmaceutical policy research. It covers all aspects of scientific research from conceptualising to statistical analysis. It also provides scientific basis and a good understanding of the principles and practice of conducting pharmaceutical policy research.--[Source inconnue].

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