pathophysiology of headaches from molecule to man

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Pathophysiology Of Headaches

Author : Messoud Ashina
ISBN : 9783319156217
Genre : Medical
File Size : 28. 57 MB
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This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.

Textbook Of Biochemistry Biotechnology Allied And Molecular Medicine

Author : TALWAR, G.P.
ISBN : 9788120351257
Genre :
File Size : 90. 99 MB
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The Fourth Edition of the compendium pools together the knowledge and experience of experts from all over the world, who are engaged in teaching and research in the field of biochemistry, medical sciences and allied disciplines. Comprising 20 sections, the present edition of the book has been substantially revised incorporating the latest research and achievements in the field. Beginning appropriately with chemical architecture of the living systems, role and significance of biochemical reactions, organization of specialised tissues, and importance of food and nutrition, the book explores beyond traditional boundaries of biochemistry. The knowledge of various organ systems has been expanded covering their normal function, ailments and dysfunction. A chapter on Eye and Vision explaining molecular basis of cataract and glaucoma have been added. Also, the book introduces stem cells and regenerative therapy and defines molecules associated with pleasure, happiness, stress and anxiety. A Section on Gastrointestinal and Biliary System elaborates on physiology and dysfunction including fatty liver and its implications, and hepatitis viruses. The knowledge of Human Genetics and Biochemical Basis of Inheritance has been appropriately expanded to reflect the latest advances in various domains. Besides DNA fingerprinting for identity establishment, the Section discusses epigenetics, micro-RNA and siRNA including their role in gene expression, chromatin modification and its association with human diseases, and genetic engineering. It also explores emerging areas such as metabolomics and proteomics; synthetic biology; and dual use technology in bioterrorism. Due emphasis has been given to the Section on Cell Replication and Cancer. Emergence of the use of probiotics in human health has also been highlighted. Besides, an entire Section has been devoted to male and female reproductive systems, fertilization, implantation, pregnancy, lactation, and assisted reproductive technology. Immunology, including vaccines and immunization, has been given due attention with latest updates in this fast growing area. Modern medicine, despite its stupendous advances cannot provide cure for all ailments. Thus, the new edition provides knowledge of alternative medicine systems—Ayurveda, Homeopathy, Unani, Yoga and Herbal Medicine. Incorporating vast information on the latest and emerging areas, the book will be of immense value to the students of medical sciences not only in their preclinical years, but also in all phases of medical course including postgraduate education and practice. Besides, it will also serve as a valuable source to the students of biochemistry and human bi

Neurobiological Basis Of Migraine

Author : Turgay Dalkara
ISBN : 9781118967218
Genre : Medical
File Size : 87. 70 MB
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Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.

Molecular Neurology

Author : Stephen Waxman
ISBN : 0080546188
Genre : Medical
File Size : 27. 65 MB
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Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

Serotonin Molecular Biology Receptors And Functional Effects

Author : FOZARD
ISBN : 9783034872591
Genre : Science
File Size : 87. 9 MB
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The Second IUPHAR Satellite Meeting on Serotonin was held under the auspices of the Serotonin Club in Basel, Switzerland in July 1990. The scope was wide, ranging from molecular biology through in vitro and in vivo pharmacology to new drug tools and their clinical signifi cance. There were three invited review lectures, by J. M. Palacios, D. I. Wallis and A. Kaumann, and S. Peroutka gave the first Serotonin Club Irvine H. Page Lecture. The rest of the oral programme was put together by the Scientific Organizing Committee based on volunteered research contributions. The invited review lecturers, the platform speak ers and selected poster contributors were invited to write up their contributions for inclusion in this volume. Most complied and this book is the result of their efforts. When instructing the authors prior to the meeting, we emphasized that selected new data should be put in the context of the literature findings. In this way we hoped to achieve topicality yet preserve the review perspective which facilitates its appreciation by the non-special ist. It was truly a pleasure to read the interesting papers which resulted and to prepare them for publication. We believe they convey to a remarkable degree the spirit of what was generally felt to be a highly stimulating exchange of information on matters serotonergic which took place in Basel last July.

Migraine And Headache Pathophysiology

Author : Lars Edvinsson
ISBN : 1853177377
Genre : Health & Fitness
File Size : 23. 17 MB
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Migraine Pathophysiology provides an overview of current and accepted methodologies for the experimental study of migraine of primary headache syndromes in the laboratory in animals and man. It gives the reader a view of the current status and direct basic scientists and the pharmaceutical industry in choosing experimental situations for developing new therapies.

Migraine A Neuroinflammatory Disease

Author : Egilius L.H. Spierings
ISBN : 9783034881319
Genre : Science
File Size : 34. 36 MB
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The potential involvement of neurogenic inflammation in the pathogenesis of the migraine headache and the inhibition of this mechanism as a possible mode of action of antimigraine medications are discussed in great depth in this volume. The topics are approached from a pathophysiological as well as a clinical experimental perspective by a renowned group of clinicians and scientists who carefully consider the current, future, and potential therapeutic approaches to migraine treatment. The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. Subsequent chapters present models of neurogenic inflammation related to the pathogenesis of the migraine headache, focussing on the mediators and their receptors, as well as on the involvement of mast cells. The possibility of inhibition of neurogenic inflammation in abortive and preventive migraine treatment is also extensively discussed and a chapter on the question of whether migraine is a neuroinflammatory disease concludes this comprehensive analysis. Clinicians and scientists interested in inflammation from a physiological or pharmacological perspective and those interested in the pathogenesis of headache - migraine in particular - are the intended audience for this unique body of work.

Managing Your Headaches

Author : Mark W. Green
ISBN : 9780387218441
Genre : Medical
File Size : 44. 94 MB
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Headaches seriously affect the quality of life for millions of sufferers. The result range from lost productivity and lost income to restricted ability and low self-esteem. For many it takes years to find the appropriate medication. In this accessible book the authors explain what information you should record for your physician, what a physician is looking for in a neurological examination, and what you should and should not do to reduce the frequency and severity of your headaches. The authors discuss various important aspects of headaches. Topics include: the effects of stress, psychological factors, food triggers, and environmental risks, the symptoms of migraine, cluster and tension-type headaches, and others. This book is a must-have for anybody suffering from headaches.

Tributes To Yuan Cheng Fung On His 90th Birthday

Author : Shu Chien
ISBN : 9789814289955
Genre : Medical
File Size : 62. 19 MB
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This book is a tribute to Professor Yuan-Cheng Fung, the Father of Biomechanics and a pioneer in Bioengineering, in honor of his 90th Birthday. The book consists of articles contributed by his colleagues, students, friends and family. These articles illustrate Professor Fung's profound influence on outstanding leaders in bioengineering, especially biomechanics, and on the life and work of all people who have been in contact with him. The scientific topics covered range from fundamentals of science and engineering (e.g., residual stress, flow dynamics, and cellular signaling) to clinical disorders (e.g., atherosclerosis, diabetes, and hypertension). The articles cover the whole spectrum of biological hierarchy, from genes/molecules to cells/tissues, and organs/systems, with close correlations between engineering and biomedical sciences. This book provides an excellent view of the marvelous contributions of Professor Fung as a Renaissance Man. Sample Chapter(s). Chapter 1: Physical Mechanisms of Soft Tissues Rheological Properties (150 KB). Contents: Physical Mechanisms of Soft Tissues Rheological Properties (Y Lanir); Biomechanics of an Isolated Single Stress Fiber (M Sato & S Deguchi); The Origin of Pre-Stress in Biological Tissues OCo A Mechano-Electrochemical Model: A Tribute to Professor Y-C Fung (L Q Wan et al.); How Blood Flow Shapes Neointima (S Q Liu & Y C Fung); Illuminating a Path: Role of Biomechanics in Understanding Adaptive Remodeling in the Microcirculation (T C Skalak); Computational Simulations of the Buckling of Oval and Tapered Arteries (A Northcutt et al.); Role of Structural and Signaling Molecules in Cardiac Mechanotransduction (A M Raskin et al.); A Novel Hemodynamic Analysis of Echocardiograms (T-K Hung); In Vitro Biomechanical Studies in Aging Human Lungs (S Majd & M Yen); Modeling the Oxygen Uptake in Pulmonary Alveolar Capillaries (C-J Chuong); Two Bioengineering Solutions for a Pulmonary Circulation (J B West); Fluid Flow Induced Calcium Response in Bone Cell Network (B Huo et al.); Analysis of the Models for Cytoskeletal Rheology (R D Kamm et al.); Y-C Fung and the Biomechanics of Hearing (R Z Gan); A Model for a Class of Diffusion-Based Intercellular Communication (S Nemat-Nasser & A V Amirkhizi); Stem Cells, Biomechanics, and Y C Fung (T Ashan et al.); Of Mice and Men OC And a China Connection (D P Giddens et al.); Multi-Patient FSI Studies for Atherosclerotic Carotid Plaque Progression Based on Serial Magnetic Resonance Imaging (D-L Tang et al.); Current Status on Countermeasures for Intradialytic Hypotension (J-S Lee); Pressure Ulcer, Pressure and Flow Motion (Z-Y Lee et al.); and other Tribute articles. Readership: Academics and research scientists in the field of bioengineering, mechanical engineering and biomedical disciplines, scientists in industry, government and other institutions, and the general public.

Molecular Pathology Of Endocrine Diseases

Author : Jennifer L. Hunt
ISBN : 1441917071
Genre : Medical
File Size : 81. 81 MB
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The past two decades have seen an ever accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Mole- lar diagnostics, molecular targeted therapy, and genetic therapy are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, medical oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical inves- gators, pathologists and medical laboratory directors, and radiologists require a basic understanding of the fundamentals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice.

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