pathophysiology of headaches from molecule to man

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Pathophysiology Of Headaches

Author : Messoud Ashina
ISBN : 9783319156217
Genre : Medical
File Size : 32. 31 MB
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This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.

Headache And Migraine Biology And Management

Author : Seymour Diamond
ISBN : 9780128011621
Genre : Science
File Size : 71. 23 MB
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There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field. A practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs Features chapters from leading physicians and researchers in headache medicine Full-color text that includes both an overview of multiple disciplines and discusses the measures that can be used to treat headaches

Men In White Coats

Author : George Szmukler
ISBN : 9780198801047
Genre : Medical
File Size : 65. 56 MB
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Mental health laws surrounding psychiatric treatment under coercion have remained largely unchanged since the eighteenth century. The grounds for involuntary treatment in psychiatry are first, that the patient has a "mental disorder" that warrants treatment; and second, that the patient needsto be treated in the interests of his or her safety or for the protection of others. Men in White Coats: Treatment under Coercion is an accessible and timely resource on medical treatment under coercion and its justifications. Split into thirteen chapters, George Szmukler examines the current grounds for involuntary treatment of patients with mental disorders. He argues that theexisting laws are both discriminatory and morally unacceptable, and that they should be replaced by an entirely different approach for over-riding treatment refusals.Using case studies and real-life experiences, Men in White Coats: Treatment under Coercion discusses how involuntary treatment in psychiatric practice affects patients, their families, and society, and looks to potential solutions to the current legal frameworks surrounding coercion that could bemade applicable across all medical specialties and settings.

Headache And Comorbidities In Childhood And Adolescence

Author : Vincenzo Guidetti
ISBN : 9783319547268
Genre : Medical
File Size : 78. 28 MB
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This book aims to provide clinicians and other practitioners and professionals with up-to-date information on how to evaluate and manage headaches in children and adolescents, highlighting the most recent recommendations. Unlike in other books on the subject, detailed attention is devoted to the various comorbidities commonly associated with headache, including psychiatric comorbidities such as depression, anxiety, attention deficit hyperactivity disorder, and learning disabilities and medical conditions such as epilepsy, vascular disorders, brain tumors, atopic disease, and obesity. The intimate link between these conditions and headache is explained with a view to enabling the reader to recognize their presence and, on that basis, to institute the most effective pharmacological or non-pharmacological treatment strategy. Moreover, knowledge of the comorbidities associated with headache will help readers to understand more fully the causes of this serious disorder and also its consequences, e.g., for school performance, relationships, and daily activities. The authors are all international experts who care for children with headache or the other described disorders.

Textbook Of Biochemistry Biotechnology Allied And Molecular Medicine

Author : TALWAR, G.P.
ISBN : 9788120351257
Genre :
File Size : 77. 2 MB
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The Fourth Edition of the compendium pools together the knowledge and experience of experts from all over the world, who are engaged in teaching and research in the field of biochemistry, medical sciences and allied disciplines. Comprising 20 sections, the present edition of the book has been substantially revised incorporating the latest research and achievements in the field. Beginning appropriately with chemical architecture of the living systems, role and significance of biochemical reactions, organization of specialised tissues, and importance of food and nutrition, the book explores beyond traditional boundaries of biochemistry. The knowledge of various organ systems has been expanded covering their normal function, ailments and dysfunction. A chapter on Eye and Vision explaining molecular basis of cataract and glaucoma have been added. Also, the book introduces stem cells and regenerative therapy and defines molecules associated with pleasure, happiness, stress and anxiety. A Section on Gastrointestinal and Biliary System elaborates on physiology and dysfunction including fatty liver and its implications, and hepatitis viruses. The knowledge of Human Genetics and Biochemical Basis of Inheritance has been appropriately expanded to reflect the latest advances in various domains. Besides DNA fingerprinting for identity establishment, the Section discusses epigenetics, micro-RNA and siRNA including their role in gene expression, chromatin modification and its association with human diseases, and genetic engineering. It also explores emerging areas such as metabolomics and proteomics; synthetic biology; and dual use technology in bioterrorism. Due emphasis has been given to the Section on Cell Replication and Cancer. Emergence of the use of probiotics in human health has also been highlighted. Besides, an entire Section has been devoted to male and female reproductive systems, fertilization, implantation, pregnancy, lactation, and assisted reproductive technology. Immunology, including vaccines and immunization, has been given due attention with latest updates in this fast growing area. Modern medicine, despite its stupendous advances cannot provide cure for all ailments. Thus, the new edition provides knowledge of alternative medicine systems—Ayurveda, Homeopathy, Unani, Yoga and Herbal Medicine. Incorporating vast information on the latest and emerging areas, the book will be of immense value to the students of medical sciences not only in their preclinical years, but also in all phases of medical course including postgraduate education and practice. Besides, it will also serve as a valuable source to the students of biochemistry and human bi

Molecules Of Emotion

Author : Candace Pert
ISBN : 9781471109706
Genre : Science
File Size : 53. 91 MB
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Why do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.

Neurobiological Basis Of Migraine

Author : Turgay Dalkara
ISBN : 9781118967195
Genre : Medical
File Size : 61. 68 MB
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Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.

Acupressure Guide

Author : Aaron Stein
ISBN : 1607787784
Genre : Acupressure
File Size : 88. 25 MB
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You have the potential to relieve most ailments with your hands. Acupressure is an ancient art practiced by Chinese for over 5,000 years. This fully illustrated guide by Aaron Stein, PhD, distills acupressure into simple exercises that can be used to alleviate wide range of medical conditions. Since its release in 2003 over 100,000 people purchased the guide! AILMENTS COVERED BY THE GUIDE: HEADACHE AND MIGRAINE: Frontal Headache, Back of the head, Side of the head, Top of the head, Pain in the eye LOCAL PAIN: Jaw, Toothache, Ear, Neck, Shoulder, Wrist, Hand, Backache, Hip, Knee, Ankle, Foot COLD AND FLU: Sore throat, Sinusitis, Loss of Voice, Earaches, Allergy NERVOUS SYSTEM: Anxiety Attacks and Nervousness, Depression, Insomnia, Fainting, Hiccoughs, Memory and Concentration Improvement CARDIOVASCULAR: Angina, Palpitations, High Blood Pressure ABDOMINAL DISCOMFORT: Constipation, Diarrhea, Heartburn and Stomachache WOMEN ONLY: PMS and Painful Periods, Hot Flashes, Pregnancy URINARY PROBLEMS: Bed-wetting, Incontinence, Urinary retention OTHER: Nose bleeding, Allergy, Itching, Asthma, Decreased Libido, Hangover FEATURES: - Practical and fully illustrated. - Step-by-step guide to treatment of every condition. - Every step explains point location, direction of force, and duration of massage. - No previous experience necessary. - Total treatment duration for most conditions is 10 to 15 minutes. HOW ACUPRESSURE WORKS: Stimulation of active points is thought to lead to increased release of endorphins. Endorphin is a natural body painkiller. Endorphin and morphine are chemically different molecules but, by coincidence, they have very similar 3-dimensional shape. This similarity in shape allows morphine to bind the endorphin receptor, reduce pain, and induce feeling of happiness. Thus endorphin released by acupressure stimulation may lead to relaxation and normalization of body functions.

Molecular Basis Of Neurological Disorders And Their Treatment

Author : J.W. Gorrod
ISBN : 9789401131148
Genre : Medical
File Size : 78. 19 MB
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cytochemical techniques (ICC) which provide a useful adjunct to investigations by immunoblotting. A particular advantage of a cytochemical approach to the investiga tion of mitochondrial disorders is that it allows the mosaic distribution of certain of these defects to be detected, whereas the tissue homogeniza tion involved in conventional enzyme assays or immunoblotting precludes this. A further advantage of MEA or ICC is that only small amounts of tissue are needed, which is important since many of the affected patients are infants or small children. The main aim of this communica tion is to outline ways in which these techniques can be used in the diagnosis and further investigation of mitochondrial disorders. Reference will be made not only to those situations in which MEA and ICC offer advantages over standard enzyme asays and immunoblotting but also to contexts in which the reverse applies. 4. 2 MATERIALS AND METHODS Muscle biopsies for cytochemical investigation were snap-frozen using isopentane cooled to - 150°C in liquid nitrogen. Samples were stored in heat-sealed polythene packets in the vapour phase of liquid nitrogen containers. 4. 2. 1 Microphotometric enzyme assays Frozen sections 8 Jlm thick were cut using a Reichert-J ung Frigocut cryostat microtome equipped with motor-driven cutting action to maintain maximal reproducibility of section thickness. Sections were picked up on microscope slides and air-dried for 15 min at room temperature.

On Disorders Of Digestion Their Consequences And Treatment

Author : Sir Thomas Lauder BRUNTON
ISBN : UCAL:$B171967
Genre : Indigestion
File Size : 26. 55 MB
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