nanoscale imaging and characterisation of amyloid

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Nanoscale Imaging And Characterisation Of Amyloid

Author : Claire Louisa Tinker-Mill
ISBN : 9783319395340
Genre : Science
File Size : 90. 7 MB
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This thesis presents a method for reliably and robustly producing samples of amyloid-β (Aβ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide’s nanomechanical, elastic, thermal or spectroscopical properties. Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of Aβ with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.

Scanning Probe Microscopy Of Functional Materials

Author : Sergei V. Kalinin
ISBN : 144197167X
Genre : Technology & Engineering
File Size : 44. 17 MB
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The goal of this book is to provide a general overview of the rapidly developing field of novel scanning probe microscopy (SPM) techniques for characterization of a wide range of functional materials, including complex oxides, biopolymers, and semiconductors. Many recent advances in condensed matter physics and materials science, including transport mechanisms in carbon nanostructures and the role of disorder on high temperature superconductivity, would have been impossible without SPM. The unique aspect of SPM is its potential for imaging functional properties of materials as opposed to structural characterization by electron microscopy. Examples include electrical transport and magnetic, optical, and electromechanical properties. By bringing together critical reviews by leading researchers on the application of SPM to to the nanoscale characterization of functional materials properties, this book provides insight into fundamental and technological advances and future trends in key areas of nanoscience and nanotechnology.

Acoustic Scanning Probe Microscopy

Author : Francesco Marinello
ISBN : 9783642274947
Genre : Technology & Engineering
File Size : 82. 71 MB
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The combination of atomic force microscopy with ultrasonic methods allows the nearfield detection of acoustic signals. The nondestructive characterization and nanoscale quantitative mapping of surface adhesion and stiffness or friction is possible. The aim of this book is to provide a comprehensive review of different scanning probe acoustic techniques, including AFAM, UAFM, SNFUH, UFM, SMM and torsional tapping modes. Basic theoretical explanations are given to understand not only the probe dynamics but also the dynamics of tip surface contacts. Calibration and enhancement are discussed to better define the performance of the techniques, which are also compared with other classical techniques such as nanoindentation or surface acoustic wave. Different application fields are described, including biological surfaces, polymers and thin films.

Handbook Of Clinical Nanomedicine

Author : Raj Bawa
ISBN : 9789814669214
Genre : Medical
File Size : 27. 31 MB
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This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosimilars and 3D nanofabrication. While bridging the gap between basic biomedical research, engineering, medicine and law, the handbook provides a thorough understanding of nano’s potential to address (i) medical problems from both the patient and health provider's perspective, and (ii) current applications and their potential in a healthcare setting.

Natural Products Analysis

Author : Vladimir Havlicek
ISBN : 9781118876022
Genre : Science
File Size : 58. 70 MB
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This book highlights analytical chemistry instrumentation andpractices applied to the analysis of natural products and theircomplex mixtures, describing techniques for isolating andcharacterizing natural products. • Applies analytical techniques to natural productsresearch – an area of critical importance to drugdiscovery • Offers a one-stop shop for most analytical methods:x-ray diffraction, NMR analysis, mass spectrometry, and chemicalgenetics • Includes coverage of natural products basics andhighlights antibacterial research, particularly important asefforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail forboth current practitioners and beginning researchers

Comprehensive Biomaterials

Author : Paul Ducheyne
ISBN : 9780080552941
Genre : Technology & Engineering
File Size : 74. 48 MB
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Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Proceedings Of The National Academy Of Sciences Of The United States Of America

Author : National Academy of Sciences (U.S.)
ISBN : WISC:89099183980
Genre : Science
File Size : 56. 38 MB
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Progress In Nanoscale Characterization And Manipulation

Author : Rongming Wang
ISBN : 981130453X
Genre : Science
File Size : 78. 28 MB
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This book focuses on charged-particle optics and microscopy, as well as their applications in the materials sciences. Presenting a range of cutting-edge theoretical and methodological advances in electron microscopy and microanalysis, and examining their crucial roles in modern materials research, it offers a unique resource for all researchers who work in ultramicroscopy and/or materials research. The book addresses the growing opportunities in this field and introduces readers to the state of the art in charged-particle microscopy techniques. It showcases recent advances in scanning electron microscopy, transmission electron microscopy and helium ion microscopy, including advanced spectroscopy, spherical-corrected microscopy, focused-ion imaging and in-situ microscopy. Covering these and other essential topics, the book is intended to facilitate the development of microscopy techniques, inspire young researchers, and make a valuable contribution to the field.

Issues In Nanoscience And Nanoscale Research 2011 Edition

Author :
ISBN : 9781464967160
Genre : Technology & Engineering
File Size : 59. 72 MB
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Issues in Nanoscience and Nanoscale Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nanoscience and Nanoscale Research. The editors have built Issues in Nanoscience and Nanoscale Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nanoscience and Nanoscale Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Nanoscience and Nanoscale Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Nanosystem Characterization Tools In The Life Sciences

Author : Challa S. S. R. Kumar
ISBN : 3527313834
Genre : Technology & Engineering
File Size : 36. 76 MB
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This first dedicated, all-encompassing text characterizes nanomaterials intended for biological or physiological environments and biomedical applications, in particular for medicine, healthcare, pharmaceuticals and human wellness. It finally fills the gap for a concise overview of a wide range of different characterization techniques and how to best employ them in the context of nanoscale life science research. It thus serves as a single source of information gathering up the knowledge otherwise spread over many journal articles, and provides an overall picture to members of all the disciplines involved. This handy volume covers all important probing techniques, including nuclear and electron spin resonance, light scattering, infrared and Raman spectroscopy, atomic force microscopy, magnetic resonance, tomography, x-ray techniques, and microbalance measurement of antibody binding. Biochemists, biologists, chemists, materials scientists, and materials engineers as well as all others working in the pharmaceutical and chemical industries or at related research institutions will here a book of great value and importance.

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