mouse behavioral testing how to use mice in behavioral neuroscience

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Mouse Behavioral Testing

Author : Douglas Wahlsten
ISBN : 0123756758
Genre : Nature
File Size : 78. 75 MB
Format : PDF, Kindle
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Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

Behavioral Genetics Of The Mouse

Author : Susanna Pietropaolo
ISBN : 9781107044456
Genre : Psychology
File Size : 28. 52 MB
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A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.

Behavioral Genetics Of The Mouse Volume 2 Genetic Mouse Models Of Neurobehavioral Disorders

Author : Susanna Pietropaolo
ISBN : 9781316061404
Genre : Science
File Size : 35. 45 MB
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The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders; from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

What S Wrong With My Mouse

Author : Jacqueline N. Crawley
ISBN : 9780470119044
Genre : Science
File Size : 84. 97 MB
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Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Ethical Issues In Behavioral Neuroscience

Author : Grace Lee
ISBN : 9783662448663
Genre : Medical
File Size : 75. 24 MB
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Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

Encyclopedia Of Behavioral Neuroscience

Author :
ISBN : 9780080914558
Genre : Psychology
File Size : 26. 34 MB
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Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

Methods Of Behavior Analysis In Neuroscience

Author : Jerry J. Buccafusco
ISBN : 9781420041811
Genre : Science
File Size : 68. 20 MB
Format : PDF
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Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutical industry. The materials presented draw from the scholarly works of recognized experts in several fields of cognitive and behavioral neuroscience. Each contributor describes the most frequently used and most widely accepted version of the model, and each chapter includes: (1) a well-referenced introduction that covers the theory behind and the utility of the model; (2) a detailed and step-by-step methodology; and (3) an approach to the interpretation of the data presented. Many chapters also provide examples of actual experiments that use the method. This text eliminates the guesswork from the process of designing the methodology for many of the animal behavioral models that are used to study brain disorders, drug abuse, toxicology, and cognitive drug development. It will also significantly reduce the time spent assessing literature and developing models for studying animal subjects. Overall, Methods of Behavioral Analysis in Neuroscience is an invaluable reference source for the professional who seeks to comprehend the effects of disease on human cognition.

Advances In Central Nervous System Research And Treatment 2011 Edition

Author :
ISBN : 9781464921292
Genre : Medical
File Size : 36. 19 MB
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Advances in Central Nervous System Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Central Nervous System. The editors have built Advances in Central Nervous System Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Central Nervous System Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Transgenic And Knockout Models Of Neuropsychiatric Disorders

Author : Gene S. Fisch
ISBN : 9781597450584
Genre : Medical
File Size : 58. 26 MB
Format : PDF
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In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Vergleichende Verhaltensforschung

Author : K. Lorenz
ISBN : 9783709130971
Genre : Science
File Size : 83. 10 MB
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ihr eine gezielt beschnittene Doktrin zu machen, zu deren Verwaltung sich eif rige Leute drängen. - In jedem der verglichenen Fälle war das durchaus nicht , ,im Sinne der Erfinder". Da ist es zur Klärung allemal gut, zu den Quellen hinaufzusteigen und nachzusehen, wo die Ursprünge waren, und wie sich alles seinerzeit entwickelt hat. Dabei schärft sich der Blick für den wesentlichen Kern und das Beiwerk, sowie für sachliche und persönliche Gründe und Bedeutung unausweichlicher Auseinandersetzungen. So sehe ich den Sinn dieses Buches. Ob es ganz objektiv ist? - Das wäre zuviel verlangt! Denn wer kann die Entwicklung seiner Kinder ganz objektiv sehen? Daß es redlich ist, darauf kommt es an; und das muß man ihm zuerkennen. Nicht das Durchsetzen einer Doktrin wird hier betrieben, sondern hier werden dargestellt die Entwicklung und der Inhalt eines neu-entstandenen Wissenschaftszweiges und seiner vielfäl tigen und sorgsam abgewogenen Methoden. Das Buch ist aueh frei von der Meinung, man müsse - um das Gesicht zu wahren - auf Entdeckungsschritten verharren, die einst originell waren, nun aber teilweise überholt sind. Der Ver fasser zeigt sich offen jeder sinnvollen Kritik und Korrektur, ist jedoch ausrei chend unhöflich, um unhaltbare Einwände begründet abzuweisen.

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