molecular insights into development in humans studies in normal development and birth defects

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Molecular Insights Into Development In Humans

Author : Moyra Smith
ISBN : 9789814630603
Genre : Medical
File Size : 64. 63 MB
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The aim and scope of this book is to review current information on human development and processes of differentiation that have benefited from breakthrough analyses in stem cell biology, elucidation of genome and gene architecture and aspects of regulation of gene expression, analysis of signaling systems and transcription factor actions. Insights into actions of specific genes and their roles in development have been gathered through studies in patients with specific birth defects, including congenital malformations, metabolic defects and functional impairments. The book is organized into three sections, the first dealing with aspects of genomics, gene structure and regulation, analysis of signaling and function of specific organelles. The second section deals with molecular aspects of development of specific organs and structures such as, bone, face, brain, heart, liver, pancreas, kidney. The last section deals with specific malformations and tumors that provide insight into regulation of growth. Environmental factors that impact growth and development are also covered. Request Inspection Copy

Etiology And Morphogenesis Of Congenital Heart Disease

Author : Toshio Nakanishi
ISBN : 9784431546283
Genre : Medical
File Size : 74. 79 MB
Format : PDF, Kindle
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This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Heart Development And Regeneration

Author : Nadia Rosenthal
ISBN : 9780123813336
Genre : Science
File Size : 63. 1 MB
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The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. Authored by world experts in heart development and disease New research on epigenetic modifiers in cardiac development Comprehensive coverage of stem cells and prospects for cardiac regeneration Up-to-date research on transcriptional and proteomic circuits in cardiac disease Full-color, detailed illustrations

Human Malformations And Related Anomalies

Author : Roger E. Stevenson
ISBN : 9780199748082
Genre : Medical
File Size : 70. 92 MB
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This widely acclaimed reference work gives a comprehensive survey of all significant human malformations and related anomalies from the perspective of the clinician. The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. When known, the molecular or other pathogenetic basis for the malformation is given. Most anomalies are illustrated by photographs or drawings. Specific malformations are linked to syndromes through the extensive use of differential diagnosis tables. Over a decade has passed since the first edition of this book was published, and the revised edition fully incorporates the advances made in the field during the intervening years.. It reflects new understanding of human developmental biology that has emerged from molecular, cytogenetic, and biochemical studies; new observations by clinicians as well as enhanced diagnostic and prevention capacities; and more accurate and comprehensive epidemiology. By condensing much of the information presented in the first volume of the previous edition, and exercising rigorous editorial control, Drs. Stevenson and Hall and their contributors have managed to update the book while reducing its size to that of a single volume. All clinicians and scientists interested in birth defects, including pediatricians, geneticists, genetic counselors, obstetricians, and pediatric pathologists, will find this book to be an invaluable source of information.

Kelley S Textbook Of Rheumatology E Book

Author : Gary S. Firestein
ISBN : 9781455737673
Genre : Medical
File Size : 74. 86 MB
Format : PDF, Kindle
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Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face. Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints. Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated. Gain a thorough understanding of the "whys" and "hows" of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms. Apply the latest therapeutic advances through new chapters in bioengineering and tissue engineering, as well as up-to-date coverage of gout and disease-modifying drugs. Learn how the study of biomarkers across populations can help you detect diseases earlier and with greater accuracy with a new chapter on epigenetics. Diagnose, monitor, and manage rheumatic disease more effectively with expanded information on the use of ultrasound and other imaging modalities.

Larsen S Human Embryology E Book

Author : Gary C. Schoenwolf
ISBN : 9781455727919
Genre : Medical
File Size : 68. 31 MB
Format : PDF
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Larsen's Human Embryology works as a well-organized, straightforward guide to this highly complex subject, placing an emphasis on the clinical application of embryology and presenting it in an easily digestible manner. Ideal for visual students, this updated medical textbook includes a superior art program, brand-new online animations, and high-quality images throughout; clear descriptions and explanations of human embryonic development, based on all of the most up-to-date scientific discoveries and understanding, keep you abreast of the latest knowledge in the field. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Take advantage of the most current advances in molecular biology and genetics. Review the material in a flexible manner that meets your specific needs thanks to a user-friendly design. Access high-yield content and quickly locate key information with help from newly condensed text and additional summary tables. Take advantage of key pedagogical features such as opening "Summary" boxes. Visualize complex concepts more clearly than before through a superior art program and outstanding clinical content and images throughout. Reinforce your understanding of the material and how it will relate to real-life scenarios with "Embryology in Practice" clinical closers added to each chapter.

Sonography In Obstetrics Gynecology Principles And Practice Seventh Edition

Author : Arthur Fleischer
ISBN : 0071760881
Genre : Medical
File Size : 77. 42 MB
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The most authoritative guide to sonography in obstetrics and gynecology—now in full color Companion website includes images, case studies, and more Written by radiologists and ob/gyns to provide a balanced perspective, this standard-setting guide is both a clinically relevant reference text and atlas—presented in full color for the first time. It expertly examines the full spectrum of disorders and conditions you’re likely to encounter in gynecologic and maternal-fetal care, supported throughout by more than 2,000 detailed sonographic illustrations. You’ll also find the latest procedures and diagnostic guidelines for the use of sonography in ob/gyn, including 3D and 4D image processing, transvaginal sonography, and color Dopler sonography. The book opens with general obstetric sonography, covering such pivotal topics as normal pelvic anatomy and fetal echocardiography, before moving into fetal anomalies and disorders. Risk assessment and therapy, including first trimester screening and amniocentesis, are explored in the next section, while the remaining parts of the book focus on maternal disorders, gynecological sonography, and the newest complementary imaging modalities. Features The most trusted, accessible compendium of sonography in obstetrics and gynecology for residents and practitioners, filled with precise illustrations that add clarity to the text’s content All-inclusive coverage of everything from sonographic operating instruments and screening the fetal patient for syndromes and anomalies, to diagnosing the female patient for cysts, infertility, and incontinence NEW! Full-color format to aid readability and ease of use NEW! Up-to-date information on the significant advances made in three dimensional and even four-dimensional Doppler technology NEW! Learning aids: a “key points” section in each chapter; skill-building clinical scenarios; a stronger focus on differential diagnosis; multiple visuals (figure, illustration, or table) on each page; and helpful chapter-opening summaries NEW! Companion website filled with concept-clarifying images, video loops, case studies supplemented by Q&As, plus cutting-edge insights on a range of integral sonography topics NEW! SI Units incorporated throughout

Smith S Recognizable Patterns Of Human Malformation E Book

Author : Kenneth Lyons Jones
ISBN : 9780323186681
Genre : Medical
File Size : 31. 85 MB
Format : PDF
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Smith’s Recognizable Patterns of Human Malformation has long been known as the source to consult on multiple malformation syndromes of environmental and genetic etiology as well as recognizable disorders of unknown cause. This esteemed medical reference book provides you with complete and authoritative, yet accessible guidance to help accurately diagnose these human disorders, establish prognoses, and provide appropriate management and genetic counseling. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Recognize the visual signs of each environmental and genetic abnormality by consulting more than 1,500 full-color photographs and illustrations, many from the personal collections of Drs. Smith and Jones. Find all the answers you need about normal and abnormal morphogenesis, minor anomalies and their relevance, clinical approaches to specific diagnoses, and normal standards of measurement for the entire spectrum of human malformation syndromes. Efficiently identify genetic disorders in your patients with the inclusion of nearly 20 recently recognized entities/syndromes, as well as new chapters on Microdeletions and Microduplication Syndromes.

Human Embryology And Developmental Biology E Book

Author : Bruce M. Carlson
ISBN : 9780323082792
Genre : Medical
File Size : 44. 25 MB
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This thoroughly revised 4th edition offers both clear descriptions and explanations of human embryonic development based on all the most up-to-date scientific discoveries and understanding. Particular attention is paid to the fundamental aspects of molecular mechanisms in development, introducing you to major families of important developmental molecules. Clinical aspects of development are covered throughout in boxed sections of text. First-rate illustrations complete this essential package. Integrates contemporary developmental knowledge with classical embryological understanding. Interprets complex molecular developments, to help you learn how exactly the embryo develops. Presents first-rate clinical photos and clear drawings, to help you to memorize and understand normal and abnormal development. Uses clear sections within the chapter and summaries at the end of each to help you navigate this complex subject. Includes review questions at the end of each chapter to help you assess your knowledge. Provides more coverage of molecular development to help you interpret complex information. Revises the section on the development of the head, particularly useful for dental students.

Mandell Douglas And Bennett S Principles And Practice Of Infectious Diseases

Author : Gerald L. Mandell
ISBN : UCSD:31822036421949
Genre : Anti-infective agents
File Size : 67. 55 MB
Format : PDF
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After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett2s Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. And, as an Expert Consult title with enhanced online features, this updated 7th edition comes with convenient access to the full text online, regular updates on the new developments in the field and advances in therapy, and more at expertconsult.com. 5 Features online access of the entire book2s content- fully searchable-as well as access to regular updates on new developments in the field and advances in therapy, such as the new strain of H1N1, a drug database, downloadable image library, and more at expertconsult.com. 5 Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you2ll find in any other ID resource so you can get the answers to any questions you have. 5 Presents 1,100 exquisite color photographs that reflect real-life patient symptoms for enhanced visual guidance. 5 Offers current and up-to-date information on the newly recognized and emerging influenza viruses including Swine and Avian influenzas so you are able to accurately diagnose and treat anything that comes your way. 5 Uses a consistent chapter-to-chapter layout for easy navigation.

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