glowing genes a revolution in biotechnology

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Glowing Genes

Author : Marc Zimmer
ISBN : UOM:39015059244635
Genre : Science
File Size : 82. 84 MB
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Marc Zimmer has written the first popular science book on an amazing new area of biotechnology that will help fight cancer, create new products, improve agriculture, and combat terrorism. For more than one hundred and sixty million years, green fluorescent protein has existed in one species of jellyfish. In 1994 it was cloned, giving rise to a host of useful and potentially revolutionary applications in biotechnology. Today researchers are using this ancient glowing protein to pursue exciting new discoveries, from tracking the process of bacterial infection to detecting chemical and biological agents planted by terrorists. A recognized expert in this field, Zimmer begins with an overview of the many uses of these glowing genes to kill and image cancer cells, monitor bacterial infections, and light up in the presence of pollution. He then discusses the biological reasons that glowing proteins first evolved in jellyfish and fireflies, and looks at the history of bioluminescence and the dedicated scientists who devoted their careers to explaining this phenomenon. The story of how "glowing genes" were located, cloned, and then mass-produced is in itself a fascinating tale. Zimmer next turns to the serious, and not-so-serious, uses of fluorescent proteins. In agriculture it may soon be possible to produce crops that signal dryness by glowing. In industry a red fluorescent protein originally found in corals may find a use in sheep as a substitute for environmentally harmful wool dyes. Furthermore, the glowing gene revolution has led to significantly more humane treatment of laboratory animals. No longer must animal lives be sacrificed to understand disease processes; now researchers can observe the spread of cancer and infections by treating animals with green fluorescent genes and similar proteins. In the fight against terrorism a glowing gene has been created that lights up in the presence of anthrax spores, chemical warfare agents, and landmines. And in a completely different arena, we have already seen the emergence of "transgenic art" in Alba, the fluorescent bunny rabbit. Glowing Genes is a highly informative, fascinating, and entertaining read about a burgeoning area of biotechnology that promises soon to revolutionize our world.

Illuminating Disease

Author : Marc Zimmer
ISBN : 9780199362813
Genre : Medical
File Size : 63. 99 MB
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Since scientists began experimenting with green fluorescent proteins in the middle of the 1990s, these proteins have become one of the most important tools available to researchers in modern medicine and biology. By using them to illuminate other proteins that were previously invisible even under microscope, scientists are now able to observe facets of disease that would have otherwise gone undetected. Green fluorescent proteins are a part of over three million experiments a year, and are invaluable for tasks such as tracking HIV, breeding bird flu-resistant chickens, and confirming the existe...

Genetic Engineering

Author : Mark Youngblood Herring
ISBN : 0313334730
Genre : Science
File Size : 69. 46 MB
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Presents an overview of genetic engineering, detailing its history, its techniques, and its controversial application in the cloning of animals, modification of foods, genome mapping, DNA profiling, and treatment of disease.

Luminous Pursuit Jellyfish Gfp And The Unforeseen Path To The Nobel Prize

Author : Shimomura Osamu
ISBN : 9789813202184
Genre : Science
File Size : 56. 28 MB
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This book narrates the uniquely intertwined life and scientific career of Nobel laureate Osamu Shimomura, with particular attention to his discovery of aequorin and Green Fluorescent Protein (GFP). It includes his early memories of Manchuria and wartime Japan featuring an eyewitness account of the atomic bombing of Nagasaki, his postwar studies and his travels to collect and research more than fifteen bioluminescent species, in locations ranging from Japan to San Juan Island, Bermuda, New Zealand and Norway. Dr Shimomura describes the unique combination of serendipity and perseverance that led ultimately to his 2008 Nobel Prize in chemistry. The book provides an engaging account of the life of a dedicated scientist, emphasizing the value of determination in the pursuit of pure scientific knowledge, and showing how a general understanding of science helped him open up new areas of research that have led to unforeseen applications in cell biology and medicine.


Author : Lorenzo Pavesi
ISBN : 9783540767824
Genre : Science
File Size : 59. 51 MB
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More profound understanding of the nature of light and light-matter interactions in biology has enabled many applications in the biology and medical fields. So a new discipline is born, namely biophotonics. The aim of this book is to review the current state-of-the-art of the field by means of authoritative chapters written by the world leaders of the respective fields. This book will be useful not only to professionals, but also to graduate students interested in this field.

Aglow In The Dark

Author : Vincent Pieribone
ISBN : 0674019210
Genre : Science
File Size : 28. 60 MB
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Traces the history of green fluorescent protein from its discovery in the early 1960s to its current uses in the twenty-first century, and explores how the compound has changed the field of molecular biology.

Green Fluorescent Protein

Author : Martin Chalfie
ISBN : UVA:X004953737
Genre : Science
File Size : 30. 57 MB
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Since the discovery of the gene for green fluorescent protein (GFP), derived from jellyfish, this protein that emits a green glow has initiated a revolution in molecular biosciences. With this tool, it is now possible to visualize nearly any protein of interest in any cell or tissue of any species. Since the publication of the first edition, there have been tremendously significant technological advances, including development of new mutant variants. Proteins are now available in yellow and blue, and Novel Fluorescent Proteins (NFPs) have expanded their utility in developing biosensors, biological markers, and other biological applications. This updated, expanded new edition places emphasis on the rise of NFPs, including new chapters on NFP properties with detailed protocols, applications of GFPs and NFPs in industry research, and biosensors. This book provides a solid theoretical framework, along with detailed, practical guidance on use of GFPs and NFPs with discussion of potential pitfalls. The expert contributors provide real examples in showing how to tailor GFP/NFP to specific systems, maximize expression, and enhance detection.

Hacking The Code Of Life

Author : Nessa Carey
ISBN : 1785784978
Genre :
File Size : 23. 47 MB
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In 2018 the world woke up to gene editing with a storm of controversy over twin girls born in China with genetic changes deliberately introduced by scientists - changes they will pass on to their own offspring. Genetic modification (GM) has been with us for 45 years now, but the new system known as CRISPR or gene editing can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago. But is it ethical to change the genetic material of organisms in a way that might be passed on to future generations? If a person is suffering from a lethal genetic disease, is it unethical to deny them this option? Who controls the application of this technology, when it makes 'biohacking' - perhaps of one's own genome - a real possibility?Nessa Carey's book is a thrilling and timely snapshot of a cutting-edge technology that will radically alter our futures and the way we prevent disease.

Exploring The Biomedical Revolution

Author : Howard Hughes Medical Institute
ISBN : UOM:39076002090657
Genre : Medical
File Size : 81. 33 MB
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"A vivid example of how biology, history, and medicine interact to focus on human welfare." -- American Biology Teacher

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