excitatory amino acids clinical results with antagonists

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Excitatory Amino Acids

Author : Paul L. Herrling
ISBN : 0080531342
Genre : Medical
File Size : 79. 14 MB
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Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists Reports of potential drugs in early and late clinical stages of development

Excitatory Amino Acids

Author : Academia Brasileira de Ciências
ISBN : 1586030728
Genre : Science
File Size : 77. 73 MB
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This past decade has led to many significant advances in the understanding of the function of excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has led to clinical research addressing multiple therapeutic applications of drugs that act on excitatory amino acid systems. A number of NMDA receptor anatagonists have now been studied in humans. AMPA/kainate and metabotropic receptor active compounds have left the preclinical realms of research and have moved towards or are in the clinic.

Nmda Antagonists As Potential Analgesic Drugs

Author : Dalip J.S. Sirinathsinghji
ISBN : 3764360119
Genre : Medical
File Size : 38. 11 MB
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There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. Leading scientists in excitatory amino acid and analgesia research have compiled in this volume the most recent information on molecular biology, physiology and pharmacology of NMDA receptors, their neuroanatomical localisation within specific neural pathways involved in nociception, and experimental and clinical evidence demonstrating the potential of receptor antagonists of NMDA and other excitatory amino acids in the treatment of pain states.

Excitatory Amino Acid Receptors

Author : Povl Krogsgaard-Larsen
ISBN : 0132967162
Genre : Science
File Size : 85. 60 MB
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Designed to reflect the growing awareness of the chemical aspects of excitatory amino acids, this text uses computer-based methods and X-ray techniques to depict and analyze molecules and structure-activity relationships. The book incorporates stereochemical principles into all analyses.

Aspekte Des Psychischen

Author : Udo Schneider
ISBN : 3826027299
Genre :
File Size : 62. 62 MB
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Wie facettenreich Psychiatrie sein kann, zeigen Schüler und Mitarbeiter von Herrn Prof. Dr. Dr. Hinderk M. Emrich mit diesem Buch. Dabei spannt sich der Bogen von neurobiologischer Grundlagenforschung über klinische Untersuchungen bis hin zu philosophischen Betrachtungsweisen psychiatrischer Fragestellungen. Neben den Kernthemen psychiatrischer Arbeit wie Schizophrenie, affektive Erkrankungen, Sucht und Persönlichkeitsstörungen werden auch historische Aspekte und andere interessante Randbereiche des Psychischen angesprochen.

Medicinal Chemistry Into The Millennium

Author : Malcolm M. Campbell
ISBN : UOM:39015052054635
Genre : Science
File Size : 85. 27 MB
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The topics covered in this book are particularly relevant to scientists in industries dependent on the discovery of biologically active molecules.

Advances In Neurology

Author :
ISBN : UCLA:L0079474912
Genre : Epilepsy
File Size : 79. 24 MB
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Author : J.O. Johnson
ISBN : 9789401157742
Genre : Medical
File Size : 78. 67 MB
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Neuroanesthesia contains the edited presentations of the 42nd Annual Postgraduate Course in Anesthesiology given by the Department of Anesthesiology at the University of Utah School of Medicine, February 1997. The chapters reflect recent advances in neurophysiology, pharmacology and monitoring related to the practice of neuroanesthesiology. The sections on central nervous system trauma, intraoperative management, brain protection and postoperative care provide a conceptual framework for current clinical practices. This textbook is the fifteenth in a continuing series documenting the proceedings of the Postgraduate Course of the Department of Anesthesiology of the University of Utah School of Medicine. It reflects, as well as past and future volumes, the rapid and continuing evolution of anesthesia in the last years of the twentieth century.

Angiotensin Vol Ii

Author : Bernward A. Schölkens
ISBN : 3540406417
Genre : Medical
File Size : 89. 40 MB
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with contributions by numerous experts

Neurotoxins And Their Pharmacological Implications

Author : Peter Jenner
ISBN : UOM:39015012536762
Genre : Medical
File Size : 51. 93 MB
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