environmental biomedicine advances in experimental medicine and biology

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Environmental Biomedicine

Author : Mieczyslaw Pokorski
ISBN : 9783319146904
Genre : Science
File Size : 20. 28 MB
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The book presents the latest advances in research into health effects of air pollution, with heavy motor vehicle traffic or cigarette smoke as the exemplar of pollution. The airways are the first-line defense system against pollution. The book focuses on respiratory ailments underlain by inflammation, increased susceptibility to infection, particularly acquired during harsh environmental conditions and exposures to particulate matter or pathogens. The importance of astute analysis of lung function for early diagnosis of disorders is underscored. A knowledge deficit concerning the aerosolized drug delivery through the airways also is addressed. Recent developments and viewpoints in the field of environmental health hazards as well as methodological advances in their assessment are provided. The book will be of interest to pulmonologists, healthcare providers, researchers and clinicians engaged in environment-related respiratory diseases, but also to policy makers concerned with clean ambient air quality.

Environmental Health And Biomedicine

Author : C. A. Brebbia
ISBN : 9781845645243
Genre : Medical
File Size : 81. 47 MB
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Following on the success of the first conference, the Wessex Institute of Technology is convening the Second International Conference on Physical Coastal Processes, Management and Engineering. This book contains papers to be presented at that Conference. Coastal zone dynamics involve distinctive features that stem from both near shore hydrodynamics, and the complex local behaviour of the atmosphere that is affected by the irregularity of the coastal topography and variations in land sea surface roughness and thermal properties. Complex interactions occur between the atmosphere, ocean and land, leading to large temporal and spatial differences in air-sea exchange processes and wind strength and direction. Recreational and tourism demand on coastal areas activities makes increased shore and beach protection necessary. Coastlines are often subjected to direct impact of wind, swell and storm wave activity. Many other physical phenomena, such as tides and associated currents, long waves and storm surges, also affect the dynamic behaviour of the coastal zone. With the increase in extreme events due to climate change, the role of extreme events in changing coastal zones needs to be considered. The International Conference will consider also of these and will cover such topics as: Wave modelling; Wave transformation hydrodynamics; Extreme events and sea level rise; Sea defences; Interaction between coastal defences and processes; Energy recovery; Hydrodynamic forces; Sediment transport and erosion; Pollution and dispersion; Planning and beach design; Coastal geomorphology; Coastal processes and navigation; Coastal processes and GIS; Bio-physical coastal processes; and Great Lakes problems. The book will be of interest to engineers and government officials involved with coastal zone management and development

Peptides And Peptide Based Biomaterials And Their Biomedical Applications

Author : Anwar Sunna
ISBN : 9783319660950
Genre : Science
File Size : 52. 11 MB
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Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.

Gapdh Biological Properties And Diversity

Author : Norbert W. Seidler
ISBN : 9789400747166
Genre : Medical
File Size : 46. 62 MB
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The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.

Nasopharyngeal Carcinoma

Author : Pierre Busson
ISBN : 9781461459477
Genre : Medical
File Size : 90. 78 MB
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This volume intends to contribute to “translational medicine and biology”. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the 12 chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis and various aspects of host-tumor interactions.

Cell Biology And Translational Medicine Volume 1

Author : Kursad Turksen
ISBN : 3319938665
Genre : Science
File Size : 71. 15 MB
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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. With a goal to accelerate advances by timely information exchange, this new book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series is launched. Emerging areas of regenerative medicine and translational aspects of stem cells will be covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the first volume of a continuing series.

Ecological Genomics

Author : Christian R. Landry
ISBN : 9789400773479
Genre : Science
File Size : 26. 20 MB
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Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.

Hypoxia

Author : Robert C. Roach
ISBN : 0306466961
Genre : Medical
File Size : 34. 78 MB
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Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.

Metal Ions In Biological Systems

Author : Sanat Dhar
ISBN : 9781468432404
Genre : Medical
File Size : 85. 29 MB
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The articles published in this volume are based on the papers del ivered at a conference on the Role of Metal Ions in Biological Systems held November 20 and 21, 1972, at Argonne National Laboratory. The purpose of the conference was to present to an interdiscipl inary audience of physical scientists some recent developments illustrating the chemical and environ mental participation of the heavy metal ions in the biological system. The invited speakers at the conference are special ists in the fields they describe, and the articles presented here are at a level of interest to readers with backgrounds in physical sciences who are not necessari Iy doing research in the areas described. The articles are referenced through 1972, and in some cases early 1973, and thus should also be of value to research workers. It is hoped that the book wi II be of particular interest to chemists, biologists, workers in the fields of en vironmental science and publ ic health, as wei I as graduate and senior undergraduate students in these discipl ines. The conference was sponsored by the Central States Universities, Inc. , a consortium of sixteen midwestern univer sities, the Center for Educational Affairs, Argonne National Laboratory, and the United States Atomic Energy Commission. It is my pleasure to thank the members of the conference committee for their ideas and active help in organizing the conference.

Cysteine Proteases Of Pathogenic Organisms

Author : Mark W. Robinson
ISBN : 1441984143
Genre : Medical
File Size : 42. 71 MB
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Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structure‐function relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research.

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