doves diplomats and diabetes a darwinian interpretation of type 2 diabetes and related disorders

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Doves Diplomats And Diabetes

Author : Milind Watve
ISBN : 9781461444091
Genre : Science
File Size : 21. 91 MB
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Darwinian medicine looks at the ecological and evolutionary roots of disease. A disease is an interaction between a genome and its biotic or abiotic environment and therefore a disease is essentially an ecological process. Good understanding of ecology and a Darwinian way of thinking can give us novel and useful perspectives on health and disease. If we understand the disease process better, we can certainly prevent, control as well as treat diseases in a better way. Although the thought that the origins of obesity and type 2 diabetes (T2D) might lie in our hunter gatherer adaptations is not new, research over the last decade makes us rethink many of the classical concepts. Brain and behavior is increasingly being recognized as central to all the endocrine, metabolic and immunological changes that earmark type 2 diabetes and other metabolic syndrome disorders. A major change in paradigm appears to be on the horizon and the proposed book intends to speed up the paradigm shift by raising important questions, pointing out flaws and inadequacies in the prevalent paradigm and stimulating radical rethinking which would redirect and refine the line of research as well as bring some fundamental changes in drug discovery and clinical practice. ​

Adipose Tissue Biology

Author : Michael E. Symonds
ISBN : 9783319520315
Genre : Medical
File Size : 84. 72 MB
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The past decade has seen an exponential increase in our knowledge and understanding of adipose tissue biology. This has coincided with the continued rise in obesity across all generations. Clearly despite substantial advances in research into adipose tissue this still has had limited impact on the on-going obesity epidemic across a majority of countries in the world. This book brings together many leading experts in the field to provide an up to date and comprehensive review of the key aspects of adipose tissue. It therefore includes chapters on evolution, development and inflammation together with a detailed review of brown and beige adipose tissue biology and their potential significance in preventing or combating obesity. These chapters are complemented by those on genetics and gender influences, together with nutrition through the life cycle. Ultimately the book provides an overview of the complexities of adipose tissue biology and the continuing challenge to combat obesity in the 21st century.

The Metabolic Ghetto

Author : Jonathan C. K. Wells
ISBN : 9781316679364
Genre : Science
File Size : 29. 60 MB
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Chronic diseases have rapidly become the leading global cause of morbidity and mortality, yet there is poor understanding of this transition, or why particular social and ethnic groups are especially susceptible. In this book, Wells adopts a multidisciplinary approach to human nutrition, emphasising how power relations shape the physiological pathways to obesity, diabetes, hypertension and cardiovascular disease. Part I reviews the physiological basis of chronic diseases, presenting a 'capacity-load' model that integrates the nutritional contributions of developmental experience and adult lifestyle. Part II presents an evolutionary perspective on the sensitivity of human metabolism to ecological stresses, highlighting how social hierarchy impacts metabolism on an intergenerational timescale. Part III reviews how nutrition has changed over time, as societies evolved and coalesced towards a single global economic system. Part IV integrates these physiological, evolutionary and politico-economic perspectives in a unifying framework, to deepen our understanding of the societal basis of metabolic ill-health.

Bridging The Communication Gap In Science And Technology

Author : Pallava Bagla
ISBN : 9789811010255
Genre : Language Arts & Disciplines
File Size : 58. 87 MB
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This first-of-a-kind volume provides a snapshot of existing science communication policy and practice in India across different S&T sectors, and offers solutions to building effective communication. It provides an understanding on how to avoid societal clashes in situations when science meets the public in these sectors. The editors and contributors argue that effective S&T communication leads not only to a more informed public but also benefits research itself, and in a changing society like India this is a crucial element related to good governance and policy making. In this volume, experienced masters of the craft provide practical solutions to making S&T communication more effective in a vast democracy like India, which has complex issues related to literacy levels, diverse languages, varying political will, reach, and resources. Through, discussions on cases of creating information modules for the public on the Internet, television and radio, social media, as well as traditional ways of outreach like people’s science movements, holding popular science events, and fairs, the volume provides highly valuable directions on how developing countries with low resources and complex populations can communicate S&T research to the public and bridge communication gaps. This volume will interest researchers from science, social science, mass communication and public relations departments, journalists, as well as practitioners and policy makers from government and non-government institutions involved in S&T policy, practice and communication and people who want to understand the complex S&T landscape of India.

Mechanisms Of Vascular Defects In Diabetes Mellitus

Author : C.C. Kartha
ISBN : 9783319603247
Genre : Science
File Size : 31. 53 MB
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This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality. In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia. In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers. The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section. The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes. Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin – angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes. Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglycaemia induced thrombin formation and aberrant clot lysis will be dwelled upon in Section V.Section VI includes chapters on microvascular complications of diabetes which encompasses long term complications of diabetes affecting small blood vessels of the eye, kidneys and nervous system. The pathogenesis and mechanisms of these complications would be detailed here. The final section (Section VII) of the book will consider mechanism of action of drugs for treating endothelial dysfunction in diabetes mellitus which would elaborate on lipid regulating therapies such as statins, as well as other therapies such as ACE inhibitors, Angiotensin II receptors, insulin, metformin and their effects on enhancing vascular function in diabetes.“/div>divWe intend to invite authors who symbolize a multidisciplinary approach to this complicated disease. The proposed authors include clinicians who understand the trend of vascular complications in their long term clientele, epidemiologists with a holistic view, basic and experimental researchers with years of experience in dissecting the factors leading to endothelial dysfunction and clinical researchers with the skill of translating bench work to the bedside. We expect this book will be of significant value and interest to the same group of clinicians, researchers, post doctoral fellows and medical and non medical graduate students. The novel assimilated insights could stimulate development of mechanism based prevention and therapeutic strategies providing a promising option to limit cardiovascular complications in diabetes mellitus.

Author : Joe Abercrombie
ISBN : 9786180309683
Genre : Fiction
File Size : 24. 19 MB
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Μερικές φορές ένα κορίτσι δέχεται το άγγιγμα της Πολεμόχαρης Μητέρας. Τέτοιο κορίτσι είναι και η Θορν. Πασχίζοντας να πάρει εκδίκηση για τον θάνατο του πατέρα της, ζει μονάχα για να πολεμά. Τώρα, όμως, ο άντρας που τη δίδαξε πώς να σκοτώνει την κατηγορεί για φόνο. Μερικές φορές, μια γυναίκα γίνεται πολεμίστρια. Ξαφνικά βρίσκεται μπλεγμένη στις δολοπλοκίες του Πατέρα Γιάρβι, του πανούργου θεράποντα της Γκέτλαντ. Διασχίζοντας τον μισό κόσμο, αναζητώντας συμμάχους ενάντια στον αδίστακτο Υψηλό Βασιλέα, θα υποστεί μια σκληρή μαθητεία στο αίμα και τον δόλο. Μερικές φορές, μια πολεμίστρια γίνεται όπλο. Στο ταξίδι αυτό, έχει στο πλευρό της τον Μπραντ, έναν πολεμιστή που απεχθάνεται να σκοτώνει –αποτυχημένο τόσο στα δικά της μάτια όσο και στα δικά του–, με μία και μοναδική ευκαιρία να εξιλεωθεί. Τα όπλα υπηρετούν έναν και μόνο σκοπό. Άραγε η Θορν θα παραμείνει σε όλη της τη ζωή έρμαιο των ισχυρών ή θα καταφέρει να χαράξει τον δικό της δρόμο;

Author : Joe Abercrombie
ISBN : 9786180305616
Genre : Fiction
File Size : 90. 68 MB
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«Ορκίστηκα να πάρω εκδίκηση για τον θάνατο του πατέρα μου. Μπορεί να ’μαι μισός άντρας, αλλά ο όρκος που πήρα ήταν ολόκληρος». Αδύναμος κι ανάξιος στα μάτια του πατέρα του, ο πρίγκιπας Γιάρβι είναι ολομόναχος σ’ έναν κόσμο που κυβερνάται από σιδηρά χέρια και ψυχρές καρδιές. Ανίκανος να κρατήσει ασπίδα ή να χειριστεί πέλεκυ, πρέπει ν’ ακονίσει τον νου του μέχρι να γίνει το φονικότερο απ’ όλα τα όπλα. Όταν η τραγωδία και οι δολοπλοκίες τον ξεριζώνουν από τη ζωή που γνώριζε, ο Γιάρβι ορκίζεται ν’ ανακτήσει έναν θρόνο που ποτέ δεν επιθύμησε. Πρώτα όμως πρέπει να επιβιώσει από τη σκληρότητα, τις αλυσίδες και τα πικρά νερά της Τσακισμένης Θάλασσας – κι όλα αυτά με μονάχα ένα γερό χέρι.

Oxford English Greek Learner S Dictionary

Author : Д. Н Ставропулос
ISBN : 0194312429
Genre : English language
File Size : 39. 76 MB
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This dictionary provides definitions and common usage with numerous example sentences and phrases.

Author : Thomas Wolfe
ISBN : 9786180311280
Genre : Fiction
File Size : 55. 8 MB
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Το αυτοβιογραφικό βιβλίο του Thomas Wolfe Γύρνα σπίτι, άγγελέ μου, που τον καθιέρωσε ως μια από τις λαμπρότερες λογοτεχνικές φωνές του 20ού αιώνα ασκώντας σημαντική επιρροή στο έργο πολλών μεταγενέστερων συγγραφέων, κυκλοφόρησε το 1929. Γνώρισε μεγάλη επιτυχία, διασκευάστηκε για τη θεατρική σκηνή και μεταφράστηκε σε πολλές χώρες σε όλο τον κόσμο. Το μυθιστόρημα αφηγείται την ιστορία του Ευγένιου Γκαντ που μεγαλώνει σε μια μικρή επαρχιακή αμερικάνικη πόλη στις αρχές του προηγούμενου αιώνα. Μοναχικός παρίας αλλά και παθιασμένος αντιμέτωπος με έντονες καταστάσεις και με μια οικογενειακή τραγωδία πριν συνειδητοποιήσει ότι πρέπει να αφήσει το σπίτι του αν θέλει να διαμορφώσει την προσωπική του ταυτότητα.

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