computational modeling of gene regulatory networks a primer

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Computational Modeling Of Gene Regulatory Networks

Author : Hamid Bolouri
ISBN : 9781848162204
Genre : Medical
File Size : 60. 14 MB
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This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology.

Computational Modeling Of Genetic And Biochemical Networks

Author : James M. Bower
ISBN : 0262524236
Genre : Computers
File Size : 87. 69 MB
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How new modeling techniques can be used to explore functionally relevant molecular and cellular relationships.

Handbook Of Research On Computational Methodologies In Gene Regulatory Networks

Author : Das, Sanjoy
ISBN : 9781605666860
Genre : Computers
File Size : 31. 90 MB
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"This book focuses on methods widely used in modeling gene networks including structure discovery, learning, and optimization"--Provided by publisher.

Towards A Theory Of Development

Author : Alessandro Minelli
ISBN : 9780191651182
Genre : Science
File Size : 82. 75 MB
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Is it possible to explain and predict the development of living things? What is development? Articulate answers to these seemingly innocuous questions are far from straightforward. To date, no systematic, targeted effort has been made to construct a unifying theory of development. This novel work offers a unique exploration of the foundations of ontogeny by asking how the development of living things should be understood. It explores the key concepts of developmental biology, asks whether general principles of development can be discovered, and examines the role of models and theories. The two editors (one a biologist with long interest in the theoretical aspects of his discipline, the other a philosopher of science who has mainly worked on biological systems) have assembled a team of leading contributors who are representative of the scientific and philosophical community within which a diversity of thoughts are growing, and out of which a theory of development may eventually emerge. They analyse a wealth of approaches to concepts, models and theories of development, such as gene regulatory networks, accounts based on systems biology and on physics of soft matter, the different articulations of evolution and development, symbiont-induced development, as well as the widely discussed concepts of positional information and morphogenetic field, the idea of a 'programme' of development and its critiques, and the long-standing opposition between preformationist and epigenetic conceptions of development. Towards a Theory of Development is primarily aimed at students and researchers in the fields of 'evo-devo', developmental biology, theoretical biology, systems biology, biophysics, and the philosophy of science.

Mathematical Modeling In Systems Biology

Author : Brian P. Ingalls
ISBN : 9780262018883
Genre : Science
File Size : 70. 51 MB
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Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3--8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

Kompendium Systembiologie

Author : Andreas Kremling
ISBN : 9783834886071
Genre : Science
File Size : 69. 73 MB
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Das Buch beschreibt die Grundlagen der mathematischen Modellierung zellulärer Systeme. Nach einer Klassifikation von Modellen wird schwerpunktmäßig auf deterministische Modelle eingegangen und für alle relevanten zellulären Prozesse entsprechende Gleichungen angegeben. Anschließend werden eine Reihe von Verfahren zur Modellanalyse vorgestellt. Etwas kürzer werden Verfahren zum Reverse Engineering und zur Analyse von Netzwerkgraphen abgehandelt. Am Ende werden noch Verfahren der Parameteridentifikation besprochen.

Medical Informatics

Author : Hsinchun Chen
ISBN : 9780387257396
Genre : Medical
File Size : 45. 96 MB
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Comprehensively presents the foundations and leading application research in medical informatics/biomedicine. The concepts and techniques are illustrated with detailed case studies. Authors are widely recognized professors and researchers in Schools of Medicine and Information Systems from the University of Arizona, University of Washington, Columbia University, and Oregon Health & Science University. Related Springer title, Shortliffe: Medical Informatics, has sold over 8000 copies The title will be positioned at the upper division and graduate level Medical Informatics course and a reference work for practitioners in the field.

Hybrid Artificial Intelligent Systems

Author : Emilio Corchado
ISBN : 9783642212215
Genre : Computers
File Size : 52. 33 MB
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The two LNAI volumes 6678 and 6679 constitute the proceedings of the 6th International Conference on Hybrid Artificial Intelligent Systems, HAIS 2011, held in Wroclaw, Poland, in May 2011. The 114 papers published in these proceedings were carefully reviewed and selected from 241 submissions. They are organized in topical sessions on hybrid intelligence systems on logistics and intelligent optimization; metaheuristics for combinatorial optimization and modelling complex systems; hybrid systems for context-based information fusion; methods of classifier fusion; intelligent systems for data mining and applications; systems, man, and cybernetics; hybrid artificial intelligence systems in management of production systems; habrid artificial intelligent systems for medical applications; and hybrid intelligent approaches in cooperative multi-robot systems.

Pacific Symposium On Biocomputing

Author : Russ Altman
ISBN : 9812564632
Genre : Biology
File Size : 69. 43 MB
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The Pacific Symposium on Biocomputing (PSB) 2006 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2006 will be held January 3?7, 2006 at the Grand Wailea, Maui. Tutorials will be offered prior to the start of the conference. PSB 2006 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in

Bioinformatics For Geneticists

Author : Michael R. Barnes
ISBN : 9780470026199
Genre : Computers
File Size : 70. 8 MB
Format : PDF
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Bioinformatics for geneticists describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. Including SNP functional analysis and statistical genetics.

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