circulating micrornas in disease diagnostics and their potential biological relevance experientia supplementum

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Precision Medicine

Author : Hans-Peter Deigner
ISBN : 9780128054338
Genre : Medical
File Size : 56. 18 MB
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Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation Encompasses easy access to relevant approaches, interactions and original literature

Inflammasomes Clinical And Therapeutic Implications

Author : Mario D. Cordero
ISBN : 9783319893907
Genre :
File Size : 85. 21 MB
Format : PDF, ePub
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Ticks Of Europe And North Africa

Author : Agustín Estrada-Peña
ISBN : 9783319637600
Genre : Medical
File Size : 41. 13 MB
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This book includes descriptive keys for identifying every stage of all the species of ticks reported in Europe and northern Africa. It includes descriptive texts on the ecology and prominent features of each species, together with ink illustrations and distribution maps of more than 60 species of hard and soft ticks. The text for each species was prepared by specialists, the illustrations were made especially for this book and the maps were compiled on the basis of more than 40 years of records. This book is the first to offer keys for more than 60 species of ticks (both immature and adult) in the target territory. It also includes supplementary information with bibliographical details for each species. This book is based upon work from COST Action TD1303, supported by COST (European Cooperation in Science and Technology)

Olfaction In Vector Host Interactions

Author : W. Takken
ISBN : 9789086860913
Genre : Technology & Engineering
File Size : 43. 43 MB
Format : PDF
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This is a multi-authored book with a focus on the role of olfaction (the sense of smell) in the multitude of interactions between arthropods and their blood hosts. Most arthropods, like insects, do not depend on a vertebrate host for survival and reproduction. In contrast, the fitness of those that do, depends on how efficiently they can detect the presence of a host and actively locate it to obtain a blood meal. This is the domain of olfaction, which is perhaps the most important mode of signal exchange between hosts and blood-feeding arthropods that visit them. Important human and domestic animal diseases like malaria, dengue, West Nile virus, bluetongue and trypanosomiasis are transmitted between humans and/or domestic animals as a direct outcome of olfactory responses mediated by host odours. Increased understanding of olfaction and how this governs interactions between arthropods and blood hosts will enable the development of novel strategies to disrupt this behaviour. Many species of tsetse fly, for instance, respond over distance to simple blends of synthetic odours. Combined with traps or insecticide-treated targets, such odour-baited devices can effectively suppress fly populations and thus transmission of sleeping sickness. Such systems still need to be developed for disease-vectoring mosquitoes necessitating further knowledge on the chemical basis of interactions with humans. In 18 peer-reviewed chapters, recognized experts provide a state-of-the-art overview of olfaction in vector-host interactions, from the molecular to population biology level. Novel ideas, definition of research gaps, and a collection of the most recent studies will be of value to biology students, chemical ecologists, as well as those implementing vector control programmes.

Amp Activated Protein Kinase

Author : Mario D. Cordero
ISBN : 9783319435893
Genre : Medical
File Size : 62. 20 MB
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AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.

Bioactive Components Diet And Medical Treatment In Cancer Prevention

Author : Mostafa I. Waly
ISBN : 9783319756936
Genre : Medical
File Size : 37. 58 MB
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The high rate of urbanization and a steady increase in per capita income has improved the socio-economic status of people all over the world. This has resulted in drastic changes in their lifestyle and food consumption patterns, where traditional foods are being replaced with more ready-made junk foods with few servings of fresh vegetables and fruits. It has been postulated that industrialization has caused change in food choice, dietary pattern modification and resulted in a sedentary lifestyle. In addition, contaminated foods with unsafe microbes and chemical hazards are increasing. All of these events have resulted in an increased risk of cancer, the leading cause of mortality and morbidity worldwide. This book will provide a basic understanding of cancer, its risk factors, preventive measures, and possible treatments currently available, as well as identifying the different dietary factors that might synergize with a sedentary lifestyle in the etiology of cancer, and its prevention measure.

Biomarkers In Cardiovascular Diseases

Author : Dimitris Tousoulis
ISBN : 9781466587151
Genre : Medical
File Size : 71. 72 MB
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The establishment of precise and reliable biomarker tests for the early stages of cardiovascular disease is of great importance and can be the cornerstone in the prevention of future cardiovascular disease (CVD). Furthermore, some biomarkers may provide important information concerning the pathogenesis of CVD or appear to be useful in risk stratification, in CVD diagnosis, or in monitoring therapy; many others may be risk factors themselves, representing therefore potential targets of therapy. The ideal biomarker should have the following characteristics: highly sensitive, specific, reliable, accessible, standardized, dependable, cost effective, and easily interpretable by clinicians. The present book focuses on the presentation and evaluation of the most promising classical and novel biochemical markers used in CVD (coronary artery disease, hypertension, heart failure, hyperlipidemia, peripheral arterial disease). The underlying pathophysiological characteristics of each biomarker, as well as potential clinical implications in daily practice are reviewed in this book.

Human Development Report 2016

Author : United Nations Development Programme
ISBN : 9211264138
Genre : Business & Economics
File Size : 65. 47 MB
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This report focuses on how human development can be ensured for everyone, now and in future. It starts with an account of the hopes and challenges of today's world, envisioning where humanity wants to go. This vision draws from and builds on the 2030 Agenda and the Sustainable Development Goals. It explores who has been left behind in human development progress and why. It argues that to ensure that human development reaches everyone, some aspects of the human development framework and assessment perspectives have to be brought to the fore. The Report also identifies the national policies and key strategies to ensure that will enable every human being achieve at least basic human development and to sustain and protect the gains.

Multi Targeted Approach To Treatment Of Cancer

Author : Varsha Gandhi
ISBN : 9783319122533
Genre : Medical
File Size : 86. 53 MB
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In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.

The Digital Patient

Author : C. D. Combs
ISBN : 9781118952764
Genre : Mathematics
File Size : 66. 6 MB
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A modern guide to computational models and constructive simulation for personalized patient care using the Digital Patient The healthcare industry’s emphasis is shifting from merely reacting to disease to preventing disease and promoting wellness. Addressing one of the more hopeful Big Data undertakings, The Digital Patient: Advancing Healthcare, Research, and Education presents a timely resource on the construction and deployment of the Digital Patient and its effects on healthcare, research, and education. The Digital Patient will not be constructed based solely on new information from all the “omics” fields; it also includes systems analysis, Big Data, and the various efforts to model the human physiome and represent it virtually. The Digital Patient will be realized through the purposeful collaboration of patients as well as scientific, clinical, and policy researchers. The Digital Patient: Advancing Healthcare, Research, and Education addresses the international research efforts that are leading to the development of the Digital Patient, the wealth of ongoing research in systems biology and multiscale simulation, and the imminent applications within the domain of personalized healthcare. Chapter coverage includes: The visible human The physiological human The virtual human Research in systems biology Multi-scale modeling Personalized medicine Self-quantification Visualization Computational modeling Interdisciplinary collaboration The Digital Patient: Advancing Healthcare, Research, and Education is a useful reference for simulation professionals such as clinicians, medical directors, managers, simulation technologists, faculty members, and educators involved in research and development in the life sciences, physical sciences, and engineering. The book is also an ideal supplement for graduate-level courses related to human modeling, simulation, and visualization.

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