chemical engineering in the pharmaceutical industry rd to manufacturing

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Chemical Engineering In The Pharmaceutical Industry

Author : David J. am Ende
ISBN : 9781118088104
Genre : Technology & Engineering
File Size : 43. 43 MB
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This book deals with various unique elements in the drugdevelopment process within chemical engineering science andpharmaceutical R&D. The book is intended to be used as aprofessional reference and potentially as a text book reference inpharmaceutical engineering and pharmaceutical sciences. Many of theexperimental methods related to pharmaceutical process developmentare learned on the job. This book is intended to provide many ofthose important concepts that R&D Engineers and manufacturingEngineers should know and be familiar if they are going to besuccessful in the Pharmaceutical Industry. These include basicanalytics for quantitation of reaction components– oftenskipped in ChE Reaction Engineering and kinetics books. In additionChemical Engineering in the Pharmaceutical Industryintroduces contemporary methods of data analysis for kineticmodeling and extends these concepts into Quality by Designstrategies for regulatory filings. For the current professionals,in-silico process modeling tools that streamlineexperimental screening approaches is also new and presented here.Continuous flow processing, although mainstream for ChE, is uniquein this context given the range of scales and the complex economicsassociated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts.These parts will address the fundamentals of analytical techniquesfor engineers, thermodynamic modeling, and finally provides anappendix with common engineering tools and examples of theirapplications.

Pharmaceutical Production

Author : Bill Bennett
ISBN : 0852954409
Genre : Technology & Engineering
File Size : 58. 95 MB
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Most of the significant developments of medicines have occurred in the last 70 years, and by a process of trial and error many plants and other substances have been used by man to produce certain pharmalogical effects.

12th International Symposium On Process Systems Engineering And 25th European Symposium On Computer Aided Process Engineering

Author :
ISBN : 9780444634450
Genre : Science
File Size : 44. 72 MB
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25th European Symposium on Computer-Aided Process Engineering contains the papers presented at the 12th Process Systems Engineering (PSE) and 25th European Society of Computer Aided Process Engineering (ESCAPE) Joint Event held in Copenhagen, Denmark, 31 May - 4 June 2015. The purpose of these series is to bring together the international community of researchers and engineers who are interested in computing-based methods in process engineering. This conference highlights the contributions of the PSE/CAPE community towards the sustainability of modern society. Contributors from academia and industry establish the core products of PSE/CAPE, define the new and changing scope of our results, and future challenges. Plenary and keynote lectures discuss real-world challenges (globalization, energy, environment, and health) and contribute to discussions on the widening scope of PSE/CAPE versus the consolidation of the core topics of PSE/CAPE. Highlights how the Process Systems Engineering/Computer-Aided Process Engineering community contributes to the sustainability of modern society Presents findings and discussions from both the 12th Process Systems Engineering (PSE) and 25th European Society of Computer-Aided Process Engineering (ESCAPE) Events Establishes the core products of Process Systems Engineering/Computer Aided Process Engineering Defines the future challenges of the Process Systems Engineering/Computer Aided Process Engineering community

Multivariate Analysis In The Pharmaceutical Industry

Author : Ana Patricia Ferreira
ISBN : 9780128110669
Genre : Medical
File Size : 47. 86 MB
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Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators. Targets pharmaceutical industry practitioners and regulatory staff by addressing industry specific challenges Includes case studies from different pharmaceutical companies and across product lifecycle of to introduce readers to the breadth of applications Contains information on the current regulatory framework which will shape how multivariate analysis (MVA) is used in years to come

The Management Of Chemical Process Development In The Pharmaceutical Industry

Author : Derek Walker
ISBN : 9780470259504
Genre : Medical
File Size : 37. 19 MB
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Here is a practical guide that not only presents insights into the organization and management of the disciplines involved in chemical process development but also provides basic knowledge of these disciplines, enabling process development practitioners to recognize and assimilate them in their work. This book illustrates practical considerations through many examples of the successful direction and integration of the activities of chemists, analysts, chemical engineers, and biologists, as well as safety, regulatory, and environmental professionals in productive teams. Moreover, this reference provides guidance on: Directing and carrying out specific tasks and courses of action Making and communicating clear and achievable decisions Solving problems on the spot Managing the administrative aspects of chemical process development The author, Dr. Derek Walker, has directed chemical process development work for four decades, combining firsthand chemical synthesis experience with many other disciplines needed to create chemical processes. You will benefit from his advice and unique insights into: Understanding the workings of matrix organizations Defining missions and creating action plans Developing interdisciplinary approaches to problem solving Holding review meetings, revising goals, and motivating staff Prioritizing programs and responses to emergencies In addition, you'll learn how successful chemists, in collaboration with other disciplines, define the best (green) chemistry for process scale-up, including accommodating FDA requirements in the last process steps and addressing safety and environmental matters early in their work. Case studies provide incisive perspective on these issues. A chapter on recognizing and patenting intellectual property emphasizes the importance of comprehensive literature surveys and understanding invention. A chapter on the future challenges you to think beyond narrow constraints and explore new horizons.

Pharmaceutical Process Development

Author : A. John Blacker
ISBN : 9781849731461
Genre : Science
File Size : 41. 89 MB
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This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

Biocatalysis For The Pharmaceutical Industry

Author : Junhua (Alex) Tao
ISBN : 9780470823156
Genre : Science
File Size : 67. 92 MB
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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Green Chemistry And Engineering

Author : Concepción Jiménez-González
ISBN : 1118101979
Genre : Science
File Size : 28. 97 MB
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The past, present, and future of green chemistry and greenengineering From college campuses to corporations, the past decade witnesseda rapidly growing interest in understanding sustainable chemistryand engineering. Green Chemistry and Engineering: A PracticalDesign Approach integrates the two disciplines into a singlestudy tool for students and a practical guide for working chemistsand engineers. In Green Chemistry and Engineering, theauthors—each highly experienced in implementing greenchemistry and engineering programs in industrialsettings—provide the bottom-line thinking required to notonly bring sustainable chemistry and engineering closer together,but to also move business towards more sustainable practices andproducts. Detailing an integrated, systems-oriented approach thatbridges both chemical syntheses and manufacturing processes, thisinvaluable reference covers: Green chemistry and green engineering in the movement towardssustainability Designing greener, safer chemical synthesis Designing greener, safer chemical manufacturing processes Looking beyond current processes to a lifecycle thinkingperspective Trends in chemical processing that may lead to more sustainablepractices The authors also provide real-world examples and exercises topromote further thought and discussion. The EPA defines green chemistry as the design of chemicalproducts and processes that reduce or eliminate the use orgeneration of hazardous substances. Green engineering is describedas the design, commercialization, and use of products and processesthat are feasible and economical while minimizing both thegeneration of pollution at the source and the risk to human healthand the environment. While there is no shortage of books on eitherdiscipline, Green Chemistry and Engineering is the first totruly integrate the two.

Chemical Engineering

Author : J H Harker
ISBN : 0080490646
Genre : Technology & Engineering
File Size : 70. 84 MB
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Chemical Engineering Volume 2 covers the properties of particulate systems, including the character of individual particles and their behaviour in fluids. Sedimentation of particles, both singly and at high concentrations, flow in packed and fluidised beads and filtration are then examined. The latter part of the book deals with separation processes, such as distillation and gas absorption, which illustrate applications of the fundamental principles of mass transfer introduced in Chemical Engineering Volume 1. In conclusion, several techniques of growing importance - adsorption, ion exchange, chromatographic and membrane separations, and process intensification - are described. * A logical progression of chemical engineering concepts, volume 2 builds on fundamental principles contained in Chemical Engineering volume 1 and these volumes are fully cross-referenced * Reflects the growth in complexity and stature of chemical engineering over the last few years * Supported with further reading at the end of each chapter and graded problems at the end of the book

Chemical Engineering In The Pharmaceutical Industry

Author : Mary T. am Ende
ISBN : 9781119285496
Genre : Technology & Engineering
File Size : 36. 51 MB
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A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

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