cellular ageing and replicative senescence healthy ageing and longevity

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Cellular Ageing And Replicative Senescence

Author : Suresh I.S. Rattan
ISBN : 9783319262390
Genre : Medical
File Size : 24. 10 MB
Format : PDF, Kindle
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This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Biology Of Aging

Author : Robert Arking
ISBN : 0199727627
Genre : Science
File Size : 40. 41 MB
Format : PDF
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Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: ? Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. ? A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. ? Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. ? Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. ? Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. ? Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.

Inflammation Advancing Age And Nutrition

Author : Irfan Rahman
ISBN : 9780123978073
Genre : Technology & Engineering
File Size : 26. 68 MB
Format : PDF, Kindle
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The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions

Mild Stress And Healthy Aging

Author : Eric Le Bourg
ISBN : 1402068697
Genre : Medical
File Size : 51. 42 MB
Format : PDF
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Whereas chronic stress has well known harmful effects, recent research shows that intermittent exposure of cells and organisms to mild stress can improve various biological parameters. This book brings together some of the world leaders in this area of research who present a critical analysis of the ongoing research with respect to the effects and mechanisms of action of various types of mild stress. Novel approaches to improving health and longevity are introduced.

Health Illness And Optimal Aging Second Edition

Author : Carolyn M. Aldwin, Ph.D.
ISBN : 9780826193476
Genre : Social Science
File Size : 48. 73 MB
Format : PDF, Docs
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"Aldwin and Gilmer have supplied an interesting textual model for examining health, illness, and aging. Their homogenized approach to aging research is refreshing and insightful."--Anthropology and Aging Quarterly "Clearly written at a level for college students, this is an excellent resource on aging...Highly recommended.--Choice: Current Reviews for Academic Libraries Spanning the biological and psychosocial aspects of aging, this upper-level undergraduate and graduate text integrates current findings in biology, psychology, and the social sciences to provide comprehensive, multidisciplinary coverage of the aging process. This new edition incorporates the tremendous amount of research that has come to light since the first edition was published. From a physical perspective, the text examines age-related changes and disease-related processes, the demography of the aging population, aging theories, and how to promote optimal aging. Coverage of the psychosocial aspects of aging encompasses mental health, stress and coping, spirituality, and caregiving in later years. The authors address demographic, theoretical, and methodological issues on aging, including a worldwide overview of aging demographics. The book reviews biological and psychosocial theories and offers much-needed information on longitudinal design and statistics as they relate to aging research. It discusses the aging of the major organ systems, the brain and sensory systems, and the endocrine and immune systems; basic anatomy and physiology; normal, impaired, and optimal aging; and functional health. Psychosocial factors that affect health are addressed, including the interplay between physical health and mental health, stress, coping, and social support. The text also covers current issues in social gerontology, including such promising new trends as gerontechnology and Green Houses, and provides information on health promotion programs. New to the Second Edition: Information involving retirement, volunteer opportunities, housing, and adaptation to health changes Coverage of economics and aging, including information on social security and other retirement income and the future of Medicare and Medicaid Significant new information about the regulatory systems Revised and updated chapters on death and dying and optimal aging Discussions on two models of optimal aging and valuable tips for its promotion URLs to relevant websites for additional information

Basic Biology And Clinical Impact Of Immunosenescence

Author : G. Pawelec
ISBN : 008054648X
Genre : Medical
File Size : 39. 73 MB
Format : PDF, Mobi
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Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

Kumar And Clark S Clinical Medicine E Book

Author : Parveen Kumar
ISBN : 9780702053047
Genre : Medical
File Size : 33. 31 MB
Format : PDF, ePub, Mobi
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Kumar & Clark’s Clinical Medicine 8 builds on the prize-winning formula that won the first prize in the BMA Book Awards Medicine Category in 2010 (7th edition) and 2006 (6th edition). ‘This book is comprehensive, student friendly (if still intimidating in size!) and covers such a vast breadth of knowledge. It still remains the primary ‘must-have’ text book of any budding doctor, or qualified one at that. This book is stunning in its breadth and in its ease of use. It still remains as the ‘gold-standard’ thorough guide to clinical medicine its forefathers were.’ BMA Judges 2010 'This is one of a select few books that deserves to be in most doctors' personal possession and it's as simple as that. ...’ Dr Harry Brown. New to this edition: New chapter on palliative medicine. Five times the number of margin clinical photos. New echocardiography images. Double the number of dermatological images; including all the major lesion morphologies covered in a single page. 16 new authors. New sections on protein synthesis, energy production and stem cells. New members of the International Advisory Board from India, South Africa, Poland and the Middle East. 7 new online chapters from the International Advisory Board. Key online features: 30 extra short chapters online, written by members of the International Advisory Board to cover key international issues, such as malaria, envenoming and HIV. Animated practical procedures, including lumbar puncture, central venous and bladder catheterization, arterial cannulation etc. heart and lung sounds, and interactive surface anatomy available online. Full text online through StudentConsult. Add your own notes and bookmarks. Search across all the StudentConsult resources you own online in one place. New to this edition: New chapter on palliative medicine. Five times the number of margin clinical photos. New echocardiography images. Double the number of dermatological images; including all the major lesion morphologies covered in a single page. 16 new authors. New sections on protein synthesis, energy production and stem cells. New members of the International Advisory Board from India, South Africa, Poland and the Middle East. 7 new online chapters from the International Advisory Board.

Underwood S Pathology

Author : Simon Cross
ISBN : 9780702053382
Genre : Medical
File Size : 53. 45 MB
Format : PDF, Mobi
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Underwood’s Pathology (formerly General and Systematic Pathology) is an internationally popular and highly acclaimed textbook, written and designed principally for students of medicine and the related health sciences. Pathology is presented in the context of modern cellular and molecular biology and contemporary clinical practice. After a clear introduction to basic principles, it provides comprehensive coverage of disease mechanisms and the pathology of specific disorders ordered by body system. An unrivalled collection of clinical photographs, histopathology images and graphics complement the clear, concise text. For this sixth edition, the entire book has been revised and updated. Well liked features to assist problem-based learning – including body diagrams annotated with signs, symptoms and diseases and a separate index of common clinical problems – have been retained and refereshed. Additional value is provided by the complementary online version – hosted on studentconsult.com - which includes the complete, fully searchable text, downloadable images, clinical case studies and a revised, interactive self-assessment section to check your understanding and aid exam preparation. This all combines to make Underwood’s an unsurpassed learning package in this fascinating and most central medical specialty. Contents perfectly matches needs of medical students. Very clinical approach is ideally suited to integrated courses. Each organ system chapter begins with a brief review of normal structure and function, emphasizing aspects that are important to an understanding of the subsequently discussed disease processes. Offers an unrivalled superb collection of clinical photographs, histopathology images, and graphics, approximately 700 in all, that richly depict the appearance of both healthy and diseased tissues. Extensive International Advisory Board validates contents. New co-editor, Dr Simon Cross. Structure of chapters revised to make the book much easier to use during courses that are problem- or case-based. Several new contributors and re-written chapters. Expanded International Advisory Board.

A Life Course Approach To Healthy Ageing

Author : Diana Kuh
ISBN : 9780191008184
Genre : Medical
File Size : 62. 76 MB
Format : PDF
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Healthy ageing has long been a neglected area of epidemiological research as the traditional focus has been on specific chronic diseases of older life. There is a growing consensus from scientists, research funders and policy makers that ageing itself needs to be studied from an interdisciplinary and life course perspective, to inform strategies for reducing the societal and individual costs of an ageing population. A Life Course Approach to Healthy Ageing is a synthesis of life course perspectives in epidemiology and interdisciplinary perspectives in ageing research. It brings together expert investigators of maturing birth cohort and ageing studies, cross-cutting methodologists, and authorities in ageing research and knowledge transfer from across the world in one wide-ranging volume. Contributors discuss how aspects of healthy ageing are conceptualised, defined and measured; relate to each other; change across life; and are influenced by biological, psychological and social factors operating from early life onwards. They identify research gaps, and suggest how evidence from observational studies can be strengthened through improved study design and longitudinal analysis, thereby increasing the research contribution to practice or policy change. The book considers how we might delay or slow down the progressive, generalised impairment of function that occurs at the individual, body system and cellular levels, as people grow older. It also considers the determinants of wellbeing in older people, including personal fulfilment, positive emotions and social relationships. Broad in scope, discussing topics from genetics to psychological and social wellbeing, A Life Course Approach to Healthy Ageing is a key resource for epidemiologists, social scientists, clinicians, public health physicians, policy makers and practitioners with a research interest in healthy ageing.

Telomeres And Telomerase In Aging Disease And Cancer

Author : K. Lenhard Rudolph
ISBN : 9783540737094
Genre : Medical
File Size : 52. 7 MB
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Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

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