bursting neurons and fading memories an alternative hypothesis of the pathogenesis of alzheimer s disease

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Bursting Neurons And Fading Memories

Author : Michael R. D'Andrea
ISBN : 9780128019887
Genre : Medical
File Size : 40. 51 MB
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Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Intracellular Consequences Of Amyloid In Alzheimer S Disease

Author : Michael R. D'Andrea
ISBN : 9780128043301
Genre : Science
File Size : 30. 37 MB
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Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s

Orexin And Sleep

Author : Takeshi Sakurai
ISBN : 9783319230788
Genre : Medical
File Size : 62. 80 MB
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This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.

Ultimate Computing

Author : S.R. Hameroff
ISBN : 9780444600097
Genre : Computers
File Size : 88. 72 MB
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The possibility of direct interfacing between biological and technological information devices could result in a merger of mind and machine - Ultimate Computing. This book, a thorough consideration of this idea, involves a number of disciplines, including biochemistry, cognitive science, computer science, engineering, mathematics, microbiology, molecular biology, pharmacology, philosophy, physics, physiology, and psychology.

Brain Facts

Author : -
Genre : Psychology
File Size : 58. 36 MB
Format : PDF
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Brain Facts is a primer on the brain and nervous system, published by the Society for Neuroscience. Brain Facts is a valuable resource for educators, students, and anyone interesting in learning about neuroscience. Download an audio recording of Brain Facts today, available on BrainFacts.org and through iTunes U. The brain is the most complex biological structure in the known universe. It is a topic rich with exciting new discoveries, continuing profound unknowns, and critical implications for individuals, families, and societies. Learn more about the brain and nervous system through articles, images, videos, and more on BrainFacts.org, a public information initiative of The Kavli Foundation, the Gatsby Charitable Foundation, and the Society for Neuroscience.

The Benefits Of Natural Products For Neurodegenerative Diseases

Author : M. Mohamed Essa
ISBN : 9783319283838
Genre : Medical
File Size : 76. 75 MB
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Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

The Paradoxical Brain

Author : Narinder Kapur
ISBN : 9781139495790
Genre : Psychology
File Size : 64. 30 MB
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The Paradoxical Brain focuses on a range of phenomena in clinical and cognitive neuroscience that are counterintuitive and go against the grain of established thinking. The book covers a wide range of topics by leading researchers, including: • Superior performance after brain lesions or sensory loss • Return to normal function after a second brain lesion in neurological conditions • Paradoxical phenomena associated with human development • Examples where having one disease appears to prevent the occurrence of another disease • Situations where drugs with adverse effects on brain functioning may have beneficial effects in certain situations A better understanding of these interactions will lead to a better understanding of brain function and to the introduction of new therapeutic strategies. The book will be of interest to those working at the interface of brain and behaviour, including neuropsychologists, neurologists, psychiatrists and neuroscientists.

New Treatment Perspectives In Autism Spectrum Disorders

Author : Roberto Canitano
ISBN : 9782889195305
Genre :
File Size : 77. 33 MB
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Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways dysrupted in the disease, thus contributing to identify novel drug targets.

Explaining The Brain

Author : Carl F. Craver
ISBN : 9780199299317
Genre : Philosophy
File Size : 68. 39 MB
Format : PDF
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Carl Craver investigates what we are doing when we use neuroscience to explain what>'s going on in the brain. When does an explanation succeed and when does it fail? Craver offers explicit standards for successful explanation of the workings of the brain, on the basis of a systematic view about what neuroscientific explanations are: they are descriptions of mechanisms.

From Messengers To Molecules

Author : Gernot Riedel
ISBN : 0306478625
Genre : Medical
File Size : 51. 26 MB
Format : PDF, Kindle
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The decade of the brain has brought us a few steps closer to some of the key questions in neuroscience. The complexity of memory is seen on the systems and cellular level, and different types of memory are implemented in several cellular changes that can interact, or work independently. From Messengers to Molecules: Memories are Made of These, follows the arguments from different research teams for their particular area of expertise. All chapters are written to stand-alone and provide an up-to-date introduction to the topic for both specialists and novices alike. As a result, a comprehensive compendium covering cellular mechanisms contributing to memory formation in an unusual breadth has emerged. This books will be of interest to researchers working on the pharmacology, physiology and genetics of memory formation, clinicians memory disorders, industry and students in advanced courses in Neuroscience or Pharmacology.

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