biostatistical methods the assessment of relative risks wiley series in probability and statistics

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Biostatistical Methods

Author : John M. Lachin
ISBN : 9781118625842
Genre : Mathematics
File Size : 23. 14 MB
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Praise for the First Edition ". . . an excellent textbook . . . an indispensable reference for biostatisticians and epidemiologists." —International Statistical Institute A new edition of the definitive guide to classical and modern methods of biostatistics Biostatistics consists of various quantitative techniques that are essential to the description and evaluation of relationships among biologic and medical phenomena. Biostatistical Methods: The Assessment of Relative Risks, Second Edition develops basic concepts and derives an expanded array of biostatistical methods through the application of both classical statistical tools and more modern likelihood-based theories. With its fluid and balanced presentation, the book guides readers through the important statistical methods for the assessment of absolute and relative risks in epidemiologic studies and clinical trials with categorical, count, and event-time data. Presenting a broad scope of coverage and the latest research on the topic, the author begins with categorical data analysis methods for cross-sectional, prospective, and retrospective studies of binary, polychotomous, and ordinal data. Subsequent chapters present modern model-based approaches that include unconditional and conditional logistic regression; Poisson and negative binomial models for count data; and the analysis of event-time data including the Cox proportional hazards model and its generalizations. The book now includes an introduction to mixed models with fixed and random effects as well as expanded methods for evaluation of sample size and power. Additional new topics featured in this Second Edition include: Establishing equivalence and non-inferiority Methods for the analysis of polychotomous and ordinal data, including matched data and the Kappa agreement index Multinomial logistic for polychotomous data and proportional odds models for ordinal data Negative binomial models for count data as an alternative to the Poisson model GEE models for the analysis of longitudinal repeated measures and multivariate observations Throughout the book, SAS is utilized to illustrate applications to numerous real-world examples and case studies. A related website features all the data used in examples and problem sets along with the author's SAS routines. Biostatistical Methods, Second Edition is an excellent book for biostatistics courses at the graduate level. It is also an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.

Biostatistical Methods

Author : John M. Lachin
ISBN : UVA:X004400479
Genre : Mathematics
File Size : 49. 63 MB
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Comprehensive coverage of classical and modern methods of biostatistics Biostatistical Methods focuses on the assessment of risks and relative risks on the basis of clinical investigations. It develops basic concepts and derives biostatistical methods through both the application of classical mathematical statistical tools and more modern likelihood-based theories. The first half of the book presents methods for the analysis of single and multiple 2x2 tables for cross-sectional, prospective, and retrospective (case-control) sampling, with and without matching using fixed and two-stage random effects models. The text then moves on to present a more modern likelihood- or model-based approach, which includes unconditional and conditional logistic regression; the analysis of count data and the Poisson regression model; and the analysis of event time data, including the proportional hazards and multiplicative intensity models. The book contains a technical appendix that presents the core mathematical statistical theory used for the development of classical and modern statistical methods. Biostatistical Methods: The Assessment of Relative Risks: * Presents modern biostatistical methods that are generalizations of the classical methods discussed * Emphasizes derivations, not just cookbook methods * Provides copious reference citations for further reading * Includes extensive problem sets * Employs case studies to illustrate application of methods * Illustrates all methods using the Statistical Analysis System(r) (SAS) Supplemented with numerous graphs, charts, and tables as well as a Web site for larger data sets and exercises, Biostatistical Methods: The Assessment of Relative Risks is an excellent guide for graduate-level students in biostatistics and an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.

Statistical Methods For Immunogenicity Assessment

Author : Harry Yang
ISBN : 9781498700351
Genre : Mathematics
File Size : 71. 10 MB
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Develop Effective Immunogenicity Risk Mitigation Strategies Immunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation. Using advanced statistical methods in the study design and analysis stages is therefore essential to immunogenicity risk assessment and mitigation strategies. Statistical Methods for Immunogenicity Assessment provides a single source of information on statistical concepts, principles, methods, and strategies for detection, quantification, assessment, and control of immunogenicity. The book first gives an overview of the impact of immunogenicity on biopharmaceutical development, regulatory requirements, and statistical methods and strategies used for immunogenicity detection, quantification, and risk assessment and mitigation. It then covers anti-drug antibody (ADA) assay development, optimization, validation, and transfer as well as the analysis of cut point, a key assay performance parameter in ADA assay development and validation. The authors illustrate how to apply statistical modeling approaches to establish associations between ADA and clinical outcomes, predict immunogenicity risk, and develop risk mitigation strategies. They also present various strategies for immunogenicity risk control. The book concludes with an explanation of the computer codes and algorithms of the statistical methods. A critical issue in the development of biologics, immunogenicity can cause early termination or limited use of the products if not managed well. This book shows how to use robust statistical methods for detecting, quantifying, assessing, and mitigating immunogenicity risk. It is an invaluable resource for anyone involved in immunogenicity risk assessment and control in both non-clinical and clinical biopharmaceutical development.

Doing Research In Emergency And Acute Care

Author : Michael P. Wilson
ISBN : 9781118643464
Genre : Medical
File Size : 81. 66 MB
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A practical guide to understanding and navigating the unique challenges faced by physicians and other professionals who wish to undertake research in the ED or other acute care setting. Focusing on the hyper-acute and acute care environment and fulfilling two closely-related needs: 1) the need for even seasoned researchers to understand the specific logistics and issues of doing research in the ED; and 2) the need to educate clinically active physicians in research methodology. This new text is not designed to be a complex, encyclopedic resource, but instead a concise, easy-to-read resource designed to convey key “need-to-know” information within a comprehensive framework. Aimed at the busy brain, either as a sit-down read or as a selectively-read reference guide to fill in knowledge gaps, chapters are short, compartmentalized, and are used strategically throughout the text in order to introduce and frame concepts. This format makes it easy - and even entertaining - for the research novice to integrate and absorb completely new (and typically dry) material. The textbook addresses aspects of feasibility, efficiency, ethics, statistics, safety, logistics, and collaboration in acute research. Overall, it grants access for the seasoned researcher seeking to learn about acute research to empathically integrate learning points into his or her knowledge base. As the ED is the primary setting for hyper-acute and acute care, and therefore a prime site for related clinical trial recruitment and interventions, the book presents specific logistical research challenges that researchers from any discipline, including physicians, research nurse coordinators, study monitors, or industry partners, need to understand in order to succeed.

Randomization In Clinical Trials

Author : William F. Rosenberger
ISBN : 9781118742150
Genre : Mathematics
File Size : 21. 7 MB
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Praise for the First Edition “All medical statisticians involved in clinical trials should read this book…” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive randomization, including minimization techniques and inference New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.

Multivariate Statistics

Author : Yasunori Fujikoshi
ISBN : 9780470411698
Genre : Mathematics
File Size : 87. 27 MB
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A comprehensive examination of high-dimensional analysis ofmultivariate methods and their real-world applications Multivariate Statistics: High-Dimensional and Large-SampleApproximations is the first book of its kind to explore howclassical multivariate methods can be revised and used in place ofconventional statistical tools. Written by prominent researchers inthe field, the book focuses on high-dimensional and large-scaleapproximations and details the many basic multivariate methods usedto achieve high levels of accuracy. The authors begin with a fundamental presentation of the basictools and exact distributional results of multivariate statistics,and, in addition, the derivations of most distributional resultsare provided. Statistical methods for high-dimensional data, suchas curve data, spectra, images, and DNA microarrays, are discussed.Bootstrap approximations from a methodological point of view,theoretical accuracies in MANOVA tests, and model selectioncriteria are also presented. Subsequent chapters feature additionaltopical coverage including: High-dimensional approximations of various statistics High-dimensional statistical methods Approximations with computable error bound Selection of variables based on model selection approach Statistics with error bounds and their appearance indiscriminant analysis, growth curve models, generalized linearmodels, profile analysis, and multiple comparison Each chapter provides real-world applications and thoroughanalyses of the real data. In addition, approximation formulasfound throughout the book are a useful tool for both practical andtheoretical statisticians, and basic results on exact distributionsin multivariate analysis are included in a comprehensive, yetaccessible, format. Multivariate Statistics is an excellent book for courseson probability theory in statistics at the graduate level. It isalso an essential reference for both practical and theoreticalstatisticians who are interested in multivariate analysis and whowould benefit from learning the applications of analyticalprobabilistic methods in statistics.

The Analysis Of Covariance And Alternatives

Author : Bradley Huitema
ISBN : 1118067460
Genre : Mathematics
File Size : 71. 67 MB
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A complete guide to cutting-edge techniques and best practices for applying covariance analysis methods The Second Edition of Analysis of Covariance and Alternatives sheds new light on its topic, offering in-depth discussions of underlying assumptions, comprehensive interpretations of results, and comparisons of distinct approaches. The book has been extensively revised and updated to feature an in-depth review of prerequisites and the latest developments in the field. The author begins with a discussion of essential topics relating to experimental design and analysis, including analysis of variance, multiple regression, effect size measures and newly developed methods of communicating statistical results. Subsequent chapters feature newly added methods for the analysis of experiments with ordered treatments, including two parametric and nonparametric monotone analyses as well as approaches based on the robust general linear model and reversed ordinal logistic regression. Four groundbreaking chapters on single-case designs introduce powerful new analyses for simple and complex single-case experiments. This Second Edition also features coverage of advanced methods including: Simple and multiple analysis of covariance using both the Fisher approach and the general linear model approach Methods to manage assumption departures, including heterogeneous slopes, nonlinear functions, dichotomous dependent variables, and covariates affected by treatments Power analysis and the application of covariance analysis to randomized-block designs, two-factor designs, pre- and post-test designs, and multiple dependent variable designs Measurement error correction and propensity score methods developed for quasi-experiments, observational studies, and uncontrolled clinical trials Thoroughly updated to reflect the growing nature of the field, Analysis of Covariance and Alternatives is a suitable book for behavioral and medical scineces courses on design of experiments and regression and the upper-undergraduate and graduate levels. It also serves as an authoritative reference work for researchers and academics in the fields of medicine, clinical trials, epidemiology, public health, sociology, and engineering.

Statistical Analysis Of Designed Experiments

Author : Ajit C. Tamhane
ISBN : 9781118491430
Genre : Science
File Size : 78. 4 MB
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A indispensable guide to understanding and designing modern experiments The tools and techniques of Design of Experiments (DOE) allow researchers to successfully collect, analyze, and interpret data across a wide array of disciplines. Statistical Analysis of Designed Experiments provides a modern and balanced treatment of DOE methodology with thorough coverage of the underlying theory and standard designs of experiments, guiding the reader through applications to research in various fields such as engineering, medicine, business, and the social sciences. The book supplies a foundation for the subject, beginning with basic concepts of DOE and a review of elementary normal theory statistical methods. Subsequent chapters present a uniform, model-based approach to DOE. Each design is presented in a comprehensive format and is accompanied by a motivating example, discussion of the applicability of the design, and a model for its analysis using statistical methods such as graphical plots, analysis of variance (ANOVA), confidence intervals, and hypothesis tests. Numerous theoretical and applied exercises are provided in each chapter, and answers to selected exercises are included at the end of the book. An appendix features three case studies that illustrate the challenges often encountered in real-world experiments, such as randomization, unbalanced data, and outliers. Minitab® software is used to perform analyses throughout the book, and an accompanying FTP site houses additional exercises and data sets. With its breadth of real-world examples and accessible treatment of both theory and applications, Statistical Analysis of Designed Experiments is a valuable book for experimental design courses at the upper-undergraduate and graduate levels. It is also an indispensable reference for practicing statisticians, engineers, and scientists who would like to further their knowledge of DOE.

Multivariate Density Estimation

Author : David W. Scott
ISBN : 9781118575536
Genre : Mathematics
File Size : 24. 33 MB
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Clarifies modern data analysis through nonparametric density estimation for a complete working knowledge of the theory and methods Featuring a thoroughly revised presentation, Multivariate Density Estimation: Theory, Practice, and Visualization, Second Edition maintains an intuitive approach to the underlying methodology and supporting theory of density estimation. Including new material and updated research in each chapter, the Second Edition presents additional clarification of theoretical opportunities, new algorithms, and up-to-date coverage of the unique challenges presented in the field of data analysis. The new edition focuses on the various density estimation techniques and methods that can be used in the field of big data. Defining optimal nonparametric estimators, the Second Edition demonstrates the density estimation tools to use when dealing with various multivariate structures in univariate, bivariate, trivariate, and quadrivariate data analysis. Continuing to illustrate the major concepts in the context of the classical histogram, Multivariate Density Estimation: Theory, Practice, and Visualization, Second Edition also features: Over 150 updated figures to clarify theoretical results and to show analyses of real data sets An updated presentation of graphic visualization using computer software such as R A clear discussion of selections of important research during the past decade, including mixture estimation, robust parametric modeling algorithms, and clustering More than 130 problems to help readers reinforce the main concepts and ideas presented Boxed theorems and results allowing easy identification of crucial ideas Figures in color in the digital versions of the book A website with related data sets Multivariate Density Estimation: Theory, Practice, and Visualization, Second Edition is an ideal reference for theoretical and applied statisticians, practicing engineers, as well as readers interested in the theoretical aspects of nonparametric estimation and the application of these methods to multivariate data. The Second Edition is also useful as a textbook for introductory courses in kernel statistics, smoothing, advanced computational statistics, and general forms of statistical distributions.

Mathematical Reviews

Author :
ISBN : UOM:39015082440879
Genre : Mathematics
File Size : 36. 96 MB
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