batch processing modeling and design

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Batch Processing

Author : Urmila Diwekar
ISBN : 9781439861196
Genre : Medical
File Size : 56. 30 MB
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Although batch processing has existed for a long time, designing these processes and unit operations has been considered an onerous task that required computational efforts. Design of these processes is made more complex because of the time dependent nature of the process and the allowable flexibility. More often than not, every unit encounters optimal control problems. Therefore, traditional design books have not covered batch processing in detail. Filling this void, Batch Processing: Modeling and Design describes various unit operations in batch and bio-processing as well as design methods for these units. Topics include: Batch distillation operating modes and configurations Batch absorption operations based on the solubility difference Batch adsorption based on differential affinity of various soluble molecules to solid absorbents Batch chromatography for measuring a wide variety of thermodynamic, kinetic, and physico-chemical properties Batch crystallization where a phase is used to find the supersaturation at which point material crystallizes Batch drying that stresses the phase diagram of water to describe this operation Batch filtration using a porous medium or screen to separate solids from liquids Batch centrifugation where centrifugal force is used for separation Batch processes are widely used in pharmaceutical, food, and specialty chemicals where high value, low volume products are manufactured. Recent developments in bio-based manufacturing also favor batch processes because feed variations can be easily handled in batch processes. Further, the emerging area of nanomaterials manufacturing currently uses batch processes as they are low volume, high energy intensive processes. With examples, case studies, and more than 100 homework problems, this book describes the unit operations in batch and bioprocessing and gives students a thorough grounding in the numerical methods necessary to solve these design problems.

Batch Processing Systems Engineering

Author : Gintaras V. Reklaitis
ISBN : 3540592016
Genre : Science
File Size : 39. 88 MB
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Batch chemical processing has in the past decade enjoyed a return to respectability as a valuable, effective, and often preferred mode of process operation. This book provides the first comprehensive and authoritative coverage that reviews the state of the art development in the field of batch chemical systems engineering, applications in various chemical industries, current practice in different parts of the world, and future technical challenges. Developments in enabling computing technologies such as simulation, mathematical programming, knowledge based systems, and prognosis of how these developments would impact future progress in the batch domain are covered. Design issues for complex unit processes and batch plants as well as operational issues such as control and scheduling are also addressed.

Batch Processes

Author : Ekaterini Korovessi
ISBN : 9781420028164
Genre : Science
File Size : 28. 86 MB
Format : PDF
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Reduced time to market, lower production costs, and improved flexibility are critical success factors for batch processes. Their ability to handle variations in feedstock and product specifications has made them key to the operation of multipurpose facilities, and therefore quite popular in the specialty chemical, pharmaceutical, agricultural, and biotechnology-enabled products industries. The editors of Batch Processes analyze the design, development, operations, and control of batch processes — providing answers to the most challenging and pressing problems associated with their use. They present a reference unique in its coverage of both process design and operations management issues. Leading experts from industry and academia contribute chapters that discuss batch process scheduling, design software tools, and the latest technologies, their implementation, and their respective advantages. The book is presented in four parts for easy reference. Part I, Batch Processing General Overview, introduces the topic and discusses batch processing industries. Part II, Batch Processing Design Issues, includes information on conceptual design and synthesis, reactors in bioindustries, distillation, crystallization, and pollution prevention. Part III, Batch Processing Management, informs the reader on modeling and optimization, planning and scheduling, monitoring and control, and supply chain management. Part IV, Future of Batch Processing, offers concluding remarks and contemplates the future of batch processing.

Understanding Batch Chemical Processes

Author : Thokozani Majozi
ISBN : 9781351679077
Genre : Science
File Size : 50. 1 MB
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Batch chemical processes, so often employed in the pharmaceutical and agrochemical fields, differ significantly from standard continuous operations in the emphasis upon time as a critical factor in their synthesis and design. With this inclusive guide to batch chemical processes, the author introduces the reader to key aspects in mathematical modeling of batch processes and presents techniques to overcome the computational complexity in order to yield models that are solvable in near real-time. This book demonstrates how batch processes can be analyzed, synthesized, and designed optimally using proven mathematical formulations. The text effectively demonstrates how water and energy aspects can be incorporated within the scheduling framework that seeks to capture the essence of time. It presents real-life case studies where mathematical modeling of batch plants has been successfully applied.

Product And Process Modelling

Author : Ian T. Cameron
ISBN : 9780080932316
Genre : Technology & Engineering
File Size : 49. 6 MB
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This book covers the area of product and process modelling via a case study approach. It addresses a wide range of modelling applications with emphasis on modelling methodology and the subsequent in-depth analysis of mathematical models to gain insight via structural aspects of the models. These approaches are put into the context of life cycle modelling, where multiscale and multiform modelling is increasingly prevalent in the 21st century. The book commences with a discussion of modern product and process modelling theory and practice followed by a series of case studies drawn from a variety of process industries. The book builds on the extensive modelling experience of the authors, who have developed models for both research and industrial purposes. It complements existing books by the authors in the modelling area. Those areas include the traditional petroleum and petrochemical industries to biotechnology applications, food, polymer and human health application areas. The book highlights to important nature of modern product and process modelling in the decision making processes across the life cycle. As such it provides an important resource for students, researchers and industrial practitioners. Ian Cameron is Professor in Chemical Engineering at the University of Queensland with teaching, research, and consulting activities in process systems engineering. He has a particular interest in process modelling, dynamic simulation, and the application of functional systems perspectives to risk management, having extensive industrial experience in these areas. He continues to work closely with industry and government on systems approaches to process and risk management issues. He received his BE from the University of New South Wales (Australia) and his PhD from imperial College London. He is a Fellow of IChemE. Rafiqul Gani is a Professor of Systems Design at the Department of Chemical and Biochemical Engineering, Technical University of Denmark, and the director of the Computer Aided Product-Process Engineering Center (CAPEC). His research interests include the development of computer-aided methods and tools for modelling, property estimation and process-product synthesis and design. He received his BSc from Bangladesh University of Engineering and Technology in 1975, and his MSc in 1976 and PhD in 1980 from Imperial College London. He is the editor-in-chief of Computers and Chemical Engineering journal and Fellow of IChemE as well as AIChE. Product and process modelling; a wide range of case studies are covered Structural analysis of model systems; insights into structure and solvability Analysis of future developments; potential directions and significant research and development problems to be addressed

Predictive Modeling Of Pharmaceutical Unit Operations

Author : Preetanshu Pandey
ISBN : 9780081001806
Genre : Medical
File Size : 83. 53 MB
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The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points

Business Process Modeling Simulation And Design Second Edition

Author : Manuel Laguna
ISBN : 9781439885284
Genre : Business & Economics
File Size : 68. 55 MB
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Most textbooks on business process management focus on either the nuts and bolts of computer simulation or the managerial aspects of business processes. Covering both technical and managerial aspects of business process management, Business Process Modeling, Simulation and Design, Second Edition presents the tools to design effective business processes and the management techniques to operate them efficiently. New to the Second Edition Three completely revised chapters that incorporate ExtendSim 8 An introduction to simulation A chapter on business process analytics Developed from the authors’ many years of teaching process design and simulation courses, the text provides students with a thorough understanding of numerous analytical tools that can be used to model, analyze, design, manage, and improve business processes. It covers a wide range of approaches, including discrete event simulation, graphical flowcharting tools, deterministic models for cycle time analysis and capacity decisions, analytical queuing methods, and data mining. Unlike other operations management books, this one emphasizes user-friendly simulation software as well as business processes, rather than only manufacturing processes or general operations management problems. Taking an analytical modeling approach to process design, this book illustrates the power of simulation modeling as a vehicle for analyzing and designing business processes. It teaches how to apply process simulation and discusses the managerial implications of redesigning processes. The ExtendSim software is available online and ancillaries are available for instructors.

Modeling Of Chemical Kinetics And Reactor Design

Author : A. Kayode Coker
ISBN : 0884154815
Genre : Technology & Engineering
File Size : 22. 81 MB
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Selecting the best type of reactor for any particular chemical reaction, taking into consideration safety, hazard analysis, scale-up, and many other factors is essential to any industrial problem. An understanding of chemical reaction kinetics and the design of chemical reactors is key to the success of the of the chemist and the chemical engineer in such an endeavor. This valuable reference volume conveys a basic understanding of chemical reactor design methodologies, incorporating control, hazard analysis, and other topics not covered in similar texts. In addition to covering fluid mixing, the treatment of wastewater, and chemical reactor modeling, the author includes sections on safety in chemical reaction and scale-up, two topics that are often neglected or overlooked. As a real-world introduction to the modeling of chemical kinetics and reactor design, the author includes a case study on ammonia synthesis that is integrated throughout the text. The text also features an accompanying CD, which contains computer programs developed to solve modeling problems using numerical methods. Students, chemists, technologists, and chemical engineers will all benefit from this comprehensive volume. Shows readers how to select the best reactor design, hazard analysis, and safety in design methodology Features computer programs developed to solve modeling problems using numerical methods

Artificial Intelligence In Process Engineering

Author : Michael Mavrovouniotis
ISBN : 9780323153140
Genre : Science
File Size : 65. 67 MB
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Artificial Intelligence in Process Engineering aims to present a diverse sample of Artificial Intelligence (AI) applications in process engineering. The book contains contributions, selected by the editors based on educational value and diversity of AI methods and process engineering application domains. Topics discussed in the text include the use of qualitative reasoning for modeling and simulation of chemical systems; the use of qualitative models in discrete event simulation to analyze malfunctions in processing systems; and the diagnosis of faults in processes that are controlled by Programmable Logic Controllers. There are also debates on the issue of quantitative versus qualitative information. The control of batch processes, a design of a system that synthesizes bioseparation processes, and process design in the domain of chemical (rather than biochemical) systems are likewise covered in the text. This publication will be of value to industrial engineers and process engineers and researchers.

22nd European Symposium On Computer Aided Process Engineering

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ISBN : 9780444594563
Genre : Science
File Size : 40. 24 MB
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Computer aided process engineering (CAPE) plays a key design and operations role in the process industries. This conference features presentations by CAPE specialists and addresses strategic planning, supply chain issues and the increasingly important area of sustainability audits. Experts collectively highlight the need for CAPE practitioners to embrace the three components of sustainable development: environmental, social and economic progress and the role of systematic and sophisticated CAPE tools in delivering these goals. Contributions from the international community of researchers and engineers using computing-based methods in process engineering Review of the latest developments in process systems engineering Emphasis on a systems approach in tackling industrial and societal grand challenges

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