antibacterial agents chemistry mode of action mechanisms of resistance and clinical applications

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Antibacterial Agents

Author : Rosaleen Anderson
ISBN : 9781118325445
Genre : Science
File Size : 23. 71 MB
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Antibacterial agents act against bacterial infection either bykilling the bacterium or by arresting its growth. They do this bytargeting bacterial DNA and its associated processes, attackingbacterial metabolic processes including protein synthesis, orinterfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this importantclass of chemotherapeutic drugs. Compounds are organised accordingto their target, which helps the reader understand the mechanism ofaction of these drugs and how resistance can arise. The book usesan integrated “lab-to-clinic” approach which coversdrug discovery, source or synthesis, mode of action, mechanisms ofresistance, clinical aspects (including links to currentguidelines, significant drug interactions, cautions andcontraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazoleantibacterial agents agents targeting metabolic processes - sulfonamideantibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolideand tetracycline antibiotics, chloramphenicol, andoxazolidinones agents targeting cell wall synthesis - β-Lactam andglycopeptide antibiotics, cycloserine, isonaizid, anddaptomycin Antibacterial Agents will find a place on the bookshelvesof students of pharmacy, pharmacology, pharmaceutical sciences,drug design/discovery, and medicinal chemistry, and as a benchreference for pharmacists and pharmaceutical researchers inacademia and industry.

Novel Antimicrobial Agents And Strategies

Author : David A. Phoenix
ISBN : 9783527676156
Genre : Medical
File Size : 66. 3 MB
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By integrating knowledge from pharmacology, microbiology, molecular medicine, and engineering, researchers from Europe, the U.S. and Asia cover a broad spectrum of current and potential antimicrobial medications and treatments. The result is a comprehensive survey ranging from small-molecule antibiotics to antimicrobial peptides and their engineered mimetics, from enzymes to nucleic acid therapeutics, from metallic nanoparticles to photo- and sonosensitizers and to phage therapy. In each case, the therapeutic approaches are compared in terms of their mechanisms, likelihood to induce resistance, and their efficiency in a global healthcare context. Unrivaled knowledge for professionals in fundamental research, pharmaceutical development and clinical practice.

Elemente Der Syntheseplanung

Author : R.W. Hoffmann
ISBN : 3827417252
Genre : Science
File Size : 56. 20 MB
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Bei der Syntheseplanung ist es wie beim Gebrauchtwagenkauf: Man kann folgenschwere Fehler machen, und jeder Fall ist anders! Und dennoch gibt es Tipps, woran man denken sollte und was man beachten muss! Dieses Buch führt in die elementaren Überlegungen ein, die man bei der Planung einer Synthese anstellen sollte. Diese Überlegungen illustriert R.W. Hoffmann mit zahlreichen Beispielen aus publizierten Synthesen. Bei jedem Beispiel gibt er die Originalliteraturstelle an, bei der Interessierte Details und weitere Erklärungen nachlesen können.

Antibiotics

Author : Claudio O. Gualerzi
ISBN : 9783527659708
Genre : Medical
File Size : 83. 5 MB
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Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Small Animal Clinical Pharmacology And Therapeutics E Book

Author : Dawn Merton Boothe
ISBN : 9781437723571
Genre : Medical
File Size : 36. 9 MB
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Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions. Comprehensive approach emphasizes the use of drugs for prevention as well as treatment. Clear, consistent organization makes it easy to find the information you need when you need it. Dosage tables help you find essential pharmaceutical information at a glance. Pharmacogenetics chapter helps you understand how to use this emerging science to find the right dose for each patient, optimizing efficiency and minimizing toxicity. Routes of administration and sample pharmaceutical calculations provide fast, efficient access to comprehensive drug administration all in one inclusive resource. Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.

Kucers The Use Of Antibiotics

Author : M. Lindsay Grayson
ISBN : 9781498747967
Genre : Medical
File Size : 73. 61 MB
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Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference. Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

Antibiotics In Laboratory Medicine

Author : Victor Lorian
ISBN : 0781749832
Genre : Medical
File Size : 35. 54 MB
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Implement the most current science and practice in antimicrobial research. Now, find the newest approaches for evaluating the activity, mechanisms of action, and bacterial resistance to antibiotics with this completely updated, landmark reference. Turn to this comprehensive reference for groundbreaking evidence on the molecular link between chemical disinfectants, sterilants, and antibiotics. On the latest methods for detecting antibacterial resistance genes in the clinical laboratory, and antivirogram use to select the most active antiviral components against your patient's HIV.

Macrolide Antibiotics

Author : Satoshi Ōmura
ISBN : 0125264518
Genre : Medical
File Size : 41. 87 MB
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Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.

Annual Reports In Medicinal Chemistry

Author :
ISBN : 0080583636
Genre : Medical
File Size : 52. 37 MB
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Annual Reports in Medicinal Chemistry

Medizinische Mikrobiologie

Author : Ernest Jawetz
ISBN : 9783662001554
Genre : Science
File Size : 76. 49 MB
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Die Autoren haben beabsichtigt, diejenigen Gebiete der medizinischen Mikrobiologie kurz, exakt und in ihrem gegenwärtigen Stand darzustellen, die für die Infektionskrankheiten und ihre Chemotherapie von besonderer Bedeutung sind. Das Buch wendet sich in erster Linie an Medizinstudenten, außerdem an alle Ärzte in Krankenhaus und Praxis. Die Notwendigkeit für ein klares Verständnis der mlkrobiologischen Grundtatsachen ist in den letzten Jahren stärker geworden, da in Biochemie, Virologie und Chemotherapie so wie auf weiteren, die Medizin beeinflussenden Gebieten bedeutende Entwicklungen statt gefunden haben. Ein wesendicher Teil dieses Lehrbuches ist deswegen der Darstellung der Grundlagen gewidmet, wodurch sich das Buch auch für die Einführung des Studenten in den mikrobiologischen Kurs als brauchbar erweisen wird. Für die neue Auflage wurde ein Kapitel über Virus und Krebs neu geschrieben, und das Kapitel über antimikrobielle Chemotherapie wurde von Grund auf neu bearbeitet. Die Autoren freuen sich, bei dem Erscheinen der 7. amerikanischen Ausgabe von einer spanischen, deutschen, italienischen und griechischen Ausgabe, sowie von der Vorbereitung für eine serbokroatische Übersetzung berichten zu können. Die Autoren möchten nochmals allen danken, die ihnen bei der Bearbeitung dieser Auf lage behilflich waren, und die es ihnen durch ihre Kommentare und ihre Kritik ermöglicht haben, die in 2jährigen Abständen erscheinenden Revisionen dieses Buches auf dem neu esten Stand zu halten. ERNEsr JAWETZ JOSEPH L MELNICK San Frandsco, August 1966 EnWARD A AnELBERG III Inhaltsverzeichnis 1 Kapitell Die ~lt der Mikroben 8 Kapitel 2 Cytologie der Bakterien Optische Methoden 8 9 Eukaryote Zellstrukturen Prokaryote Zellstrukturen . 12 14 Cytoplasmatische Strukturen. 27 Färbeverfahren .

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