antibacterial agents chemistry mode of action mechanisms of resistance and clinical applications

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Antibacterial Agents

Author : Rosaleen Anderson
ISBN : 9781118325445
Genre : Science
File Size : 53. 34 MB
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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Novel Antimicrobial Agents And Strategies

Author : David A. Phoenix
ISBN : 9783527676156
Genre : Medical
File Size : 81. 94 MB
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By integrating knowledge from pharmacology, microbiology, molecular medicine, and engineering, researchers from Europe, the U.S. and Asia cover a broad spectrum of current and potential antimicrobial medications and treatments. The result is a comprehensive survey ranging from small-molecule antibiotics to antimicrobial peptides and their engineered mimetics, from enzymes to nucleic acid therapeutics, from metallic nanoparticles to photo- and sonosensitizers and to phage therapy. In each case, the therapeutic approaches are compared in terms of their mechanisms, likelihood to induce resistance, and their efficiency in a global healthcare context. Unrivaled knowledge for professionals in fundamental research, pharmaceutical development and clinical practice.

Bioactive Heterocyclic Compound Classes

Author : Clemens Lamberth
ISBN : 9783527664474
Genre : Science
File Size : 26. 9 MB
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The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g. hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection. This volume presents important pharmaceuticals. Each of the 20 chapters covers in a concise manner one class of heterocycles, clearly structuredas follows: * Structural formulas of most important examples (market products) * Short background of history or discovery * Typical syntheses of important examples * Mode of action * Characteristic biological activity * Structure-activity relationship * Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.) * References. A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the pharmaceutical chemistry.

Modern Pharmacology With Clinical Applications

Author : Charles R. Craig
ISBN : 0316159344
Genre : Chemotherapy
File Size : 31. 85 MB
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he classic--now revised every two years! This affordable softbound is concise enough to focus on the essentials, yet detailed enough to ensure accuracy. Clearly-ordered sections address drugs affecting the autonomic nervous system, cardiovascular system, and central nervous system; drugs used to treat inflammatory disorders; chemotherapy; drugs affecting the endocrine system; and additional, important drugs such as histamines and vitamins. Numerous illustrations show correlations and mechanisms of action. Useful graphs and charts supplement the text

Antibiotics In Laboratory Medicine

Author : Victor Lorian
ISBN : 0781749832
Genre : Medical
File Size : 50. 11 MB
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Implement the most current science and practice in antimicrobial research. Now, find the newest approaches for evaluating the activity, mechanisms of action, and bacterial resistance to antibiotics with this completely updated, landmark reference. Turn to this comprehensive reference for groundbreaking evidence on the molecular link between chemical disinfectants, sterilants, and antibiotics. On the latest methods for detecting antibacterial resistance genes in the clinical laboratory, and antivirogram use to select the most active antiviral components against your patient's HIV.

A Textbook Of Pharmacology

Author : William Thomas Salter
ISBN : MINN:319510004020677
Genre : Pharmacology
File Size : 58. 49 MB
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Author : Claudio O. Gualerzi
ISBN : 9783527659708
Genre : Medical
File Size : 44. 88 MB
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Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Annual Reports In Medicinal Chemistry

Author :
ISBN : 0080583636
Genre : Medical
File Size : 41. 79 MB
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Annual Reports in Medicinal Chemistry

Macrolide Antibiotics

Author : Satoshi Ōmura
ISBN : 0125264518
Genre : Medical
File Size : 43. 91 MB
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Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.


Author : Bertram G. Katzung
ISBN : 0838577083
Genre : Pharmacology
File Size : 45. 65 MB
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Designed to complement the chapter sequence in the 7th edition of Basic and Clinical Pharmacology (Katzung), this review includes a set of objectives providing students with a checklist against which they can assess their progress. Each chapter provides a review of the core subject matter. Important drug names are provided in each chapter dealing with specific drug groups, and practice questions and answers are included at the end of each chapter. Appendices include 17 case histories with questions and answers, and test strategies.

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